Description overdue on 21.06.2012

Of anti-drug . Active ingredient - trihexyphenidyl . The drug has a muscle relaxant, peripheral and central anticholinergic effects. Cyclodol affects bradykinesia, rigidity, reduces the severity of the tremor. As a result, m-anticholinergic effects of the drug reduces the sweating, salivation. In the drug are mild local anesthetic influence. Trihexyphenidyl begins its action after an hour. In intramuscular Cyclodolum effect occurs within a few minutes. Cyclodol produced in the form of a solution in a tablet form.

Indications:

Cyclodol prescribed for Parkinson's disease, motor disorders on a background of destruction pyramidal and extrapyramidal systems in parkinsonism (postentsefalopatichesky, idiopathic, drug, atherosclerotic).

Contraindications:

Cyclodol not applied when the form-closure glaucoma, with megacolon, mechanical stenoses digestive system trigeksafenidina intolerance in pregnancy, dementia, lung edema, hyperplasia of the prostate (in case of the presence of residual urine). The elderly, patients with acute myocardial infarction, in psychosis, hypertension, tachyarrhythmias,   tachycardia , Decompensated liver disease, kidney, heart trigeksafenidin prescribed with caution, after prior consultation of experts.

Side effect:

Symptoms associated with anticholinergic activity: urinary retention, decreased sweating, tachycardia , Prostatic hypertrophy, increased intraocular pressure,   paresis of accommodation , Dryness of the mouth, constipation . Nervous system: psychoses , Impaired concentration, fatigue, irritability, dizziness, light-headedness, headache, hallucinations. The digestive tract:   vomiting, dyspeptic symptoms, nausea. Perhaps the development of purulent mumps . allergies , Drug dependence, weakness of the muscular system, flushing of the skin. With an overdose of registered motor, hyperphrenia .

Mode of application:

Cyclodol Inside, the initial dose is 0, 5-1 grams per day. If necessary, every 3-5 days, the amount of drug increased 1-2 grams. Multiplicity of reception - 3-5 times a day. Parkinsonism, Parkinson's disease 6-10 mg administered per day. The correction of extrapyramidal disorders in patients receiving medication: 5-15 mg, in the application of levodopa dose was reduced to 3-6 grams. The drug at initial hypersalivation taken after a meal, with dry oral mucosa trigeksifenidin taken before meals. A single maximum dose is 10 mg per day is not more than 20 mg.

Special instructions:

Trigeksafenidin the elderly can cause deterioration of thinking, memory. It requires regular monitoring of intraocular pressure. Prolonged therapy severity of side-effects associated with anticholinergic action of the drug decreases. In some cases the logged drug dependence . Cyclodol affects the speed of psychomotor reactions, driving vehicles.

Drug Interactions:

Severity of peripheral anticholinergic effects enhanced by appointment tricyclic antidepressants , Phenothiazine and its derivatives, H1-histamine blockers. Chlorpromazine reduces the concentration of drug in the blood. Reserpine   able to reduce the severity of antiparkinsonian effect trigeksafenidina. This mechanism involves the activation of cholinergic neurons in depletion dopapina   in the central nervous system. Under the influence of anti-levodopa increased activity that may require a dose reduction of the medication. MAO inhibitors enhance the anticholinergic effect of anticholinergics.