Description overdue on 04/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Depakine Chrono
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

The active ingredients of the drug: sodium valproate   and valproic acid .

In addition, 300 mg Depakinum Chrono contains the following additional components: hypromellose 4000 . sodium saccharin . talc . Polyacrylate dispersion 30% .   ethyl cellulose . Macrogol 6000 . Titanium dioxide . Valium .

Depakinum Chrono 500 mg, in turn, have such auxiliaries as hypromellose 4000 . Colloidal anhydrous silica . Titanium dioxide . sodium saccharin . talc . colloidal silica hydrated . Macrogol 6000 . ethyl cellulose . Valium . polyacrylate 30% .

Product form

Coated tablets, odorless or with a faint odor. Oblong form.

Pharmacological action

Anticonvulsants in epilepsy .

Pharmacodynamics and pharmacokinetics

Tablets are anticonvulsant, is effective in various forms   epilepsy .

Two known mechanism of action:

• valproic acid affects the GABAergic system . It increases the concentration of GABA in the CNS and stimulates GABAergic transmission ;
• possible influence of valproate metabolites remaining in the brain. After taking the drug increased levels of GABA.

The bioavailability of the drug when administered orally is about 100%. Mainly, the volume of distribution is limited to the blood and extracellular fluid. Active substance penetrates into the brain and CSF .

Half-life - 15-17 hours. The minimum concentration of drug in the serum is 40-50 mg / l. Maximum concentration - 200 mg / l, at a higher level it is necessary to reduce the dosage.

Stable plasma concentration - 3-4 days after application. Strong links to plasma proteins, which are dependent on dosage. Write mainly in the urine.

Indications

Adult patients prescribed this drug for treatment:

• Lennox-Gastaut syndrome ;
• generalized   and of the partial epileptic seizures ;
• Bipolar affective disorder .

Children are Depakine Chrono for the treatment of:

• partial   and generalized seizures ;
• Lennox-Gastaut syndrome .

Contraindications

The drug should not be used when:

• hypersensitivity to the components of the drug;
• chronic hepatitis ;
• hepatic porphyria ;
• body weight less than 17 kg;
• acute hepatitis ;
• admission Mefloquine   and / or St. John's wort extract ;
• children under 6 years.

Side effects

While taking the drug, the following side effects:

• diarrhea ;
• allergic reactions ;
• vomiting;
• Stevens-Johnson syndrome ;
• level decrease fibrinogen ;
• confusion ;
• increase in bleeding time;
• light tremor   hand;
• vasculitis ;
• weight gain;
• reversible Fanconi's anemia ;
• erythema multiforme ;
• nausea;
• stomach ache;
• moderate ammoniemia ;
• thrombocytopenia ;
• hair loss;
• drowsiness ;
• headache .

The symptoms are usually reversible and disappear after discontinuation of the drug.

Furthermore, in rare cases, possible following side effects:

• reversible Parkinsonism ;
• toxic epidermal necrosis ;
• lethargy Which in some cases leads to a transient coma ;
• macrocytosis ;
• pancytopenia ;
• violation of kidney function;
• amenorrhea ;
• violations of in the work of liver;
• stupor;
• reversible Dementia ;
• anemia ;
• leukopenia ;
• hearing loss;
• violation of the regularity of the menstrual cycle;
• peripheral edema.

Instructions for use Depakine Chrono

Tablets of 300 mg and 500 mg for oral application. The daily dose is divided into 1 or 2 divided doses. Once per day the medication can be applied in a highly controlled epilepsy . Instructions for use Depakine Chrono recommends taking pills during the meal.

The dosage depends on the age and weight of the patient, as well as its individual components tolerability.

Adults and children aged 6 years of age (weighing over 17 kg) administered, as a rule, the starting dose is 10-15 mg / kg, then gradually increased to the desired. Average dose - 20-30 mg / kg per day. If therapeutic effect offline, her can enlarge, however thus need carefully observe of a condition patient.

Tablets advisable not to crush or chew. If they are used as a replacement for other antiepileptic drugs, dosages need to be introduced gradually, the average dose is reached, thus, within 2 weeks. Receive be canceled drug also decreases gradually.

If other antiepileptic drugs have not been taken, the dosage Depakine Chrono increased every 2-3 days until the optimal (it will take about a week).

Other anticonvulsants on the background of Depakine Chrono should also be phased.

Overdose

When acute overdose is possible coma   from muscle hypotonia . miosis , Events metabolic acidosis . hyporeflexia   and respiratory depression .

In addition, there are cases of increased intracranial pressure due to brain edema . And possible death.

As treatment use gastric lavage, carefully watching the cardiovascular and respiratory systems that support effective diuresis . In severe situations, spend dialysis .

Cooperation

It does not take Depakine Chrono concurrently with agents that can induce seizures or decrease seizure threshold.

Strictly contraindicated in combination with:

• Mefloquine ;
• St. John's wort .

Do not combine the drug with Lamotrigine As it may cause unwanted side effects.

Precautions should be taken in conjunction with Depakine Chrono:

• Carbamazepine ;
• Felbamate ;
• Phenytoin ;
• Nimodipine ;
• Carbapenems ;
• Monobactams ;
• Phenobarbital ;
• Primidone ;
• Topiramate .

When combined with these drugs requires strict medical supervision.

Terms of sale

Depakine Chrno is released in pharmacies is strictly on prescription.

Storage conditions

Store this medication should be out of the reach of children, dry place. It is advisable not to get it out of the package. The optimum temperature - not above 25 ° C.

Shelf life

Depakine Chrono kept for 3 years.

Reviews of Depakine Chrono

Reviews of Depakine Chrono usually positive. Patients taking tablets at 300 mg and 500 mg. Regardless of the form of the release notes efficacy. However, virtually any forum has a Posts about the appearance of side effects at reception of the given means. This indicates that the drug should be taken under strict medical supervision, carefully monitoring dosage.

Price Depakine Chrono

Cost Depakine Chrono 300 mg   100 pieces per pack - an average of 1100 rubles.

Cost Depakine Chrono 500 mg   30 pieces per pack - an average of 620 rubles.