Description overdue on 07/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Depakin
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

Syrup Depakinum (Depakine) contains, as active substance sodium valproate And the following auxiliary components: methyl parahydroxybenzoate . saccharose . glycerol , Concentrated hydrochloric acid   or concentrated sodium hydroxide solution . Propyl . Sorbitol 70% , Artificial cherry flavor, purified water.

Product form

Depakine medicine produced in the form of syrup (included bilateral dosing spoon), and freeze-dried product for injection.

Pharmacological action

Anticonvulsant drug which is effective in various forms epilepsy .

Pharmacodynamics and pharmacokinetics

Depakine - anticonvulsant drug which can have sedative   and central muscle relaxant effect . At the heart of its actions is an increased concentration of GABA in the central nervous system ( gamma-aminobutyric acid ), Which reduces the excitability of the motor areas of the brain and seizure. There is another hypothesis that the drug affects the plots postsynaptic Increasing inhibitory effects of GABA.

The bioavailability of a drug after oral use - about 100%. Distribution primarily restricted blood and extracellular fluid. The medicine comes in CSF   and brain . The half - about 8-20 hours (in patients in childhood less). The minimum content of active substance in the serum, which is necessary for therapeutic effect - 40-50 mg / l. At concentrations above 200 mg / l, is necessary to reduce the dosage.

Stable plasma concentration achieved after oral administration for 3-4 days. Strong binding to plasma proteins, largely depends on the dosage.

Indications

Depakine is prescribed for:

• epilepsy   of different origin;
• febrile convulsions   in children;
• affective insanity Who has bipolar flow;
• children tick ;
• changes in the nature and conduct due epilepsy ;
• various forms seizures ;
• specific syndromes (e.g., Vesta   or Lennox-Gastaut ).

Contraindications

The product has the following contraindications:

• Hypersensitivity to the components of the drug;
• hepatic porphyria ;
• hepatic failure ;
• dysfunction of the pancreas;
• pregnancy   (especially in the I trimester);
• period Lactation ;
• bleeding diathesis ;
• expressed thrombocytopenia ;
• acute and chronic hepatitis .

Side effects

When receiving the drug, the following side effects:

• allergic reactions ;
• Stevens-Johnson syndrome ;
• confusion ;
• nausea;
• stomach ache;
• moderate ammoniemia   (does not affect the liver and does not require the cancellation of the course);
• thrombocytopenia ;
• light tremor   hand;
• vasculitis ;
• weight gain;
• erythema multiforme ;
• vomiting ;
• diarrhea ;
• Decreasing fibrinogen   or an increase in bleeding time;
• hair loss;
• drowsiness ;
• headache ;
• reversible Fanconi's anemia .

In addition, in rare cases while taking the drug side effects were observed, such as:

• stupor or lethargy ;
• reversible Dementia Which is associated with reversible brain atrophy   (runs after the drug);
• toxic epidermal necrosis ;
• reversible Parkinsonism ;
• anemia ;
• leukopenia ;
• macrocytosis ;
• pancytopenia ;
• reversible and irreversible hearing loss ;
• impairment of renal function;
• amenorrhea ;
• violation of the regularity of the menstrual cycle;
• peripheral edema;
• liver dysfunction.

Instructions for use Depakin

Instructions on Depakine includes receiving the drug inside during meals. The dosage is determined individually depending on the age and weight of the patient.

As a rule, the initial daily intake for adults and children who weigh more than 25 kg, -15 mg / kg, it increased gradually by 5-10 mg / kg every week until the maximum dosage.

Instructions for use Depakin provides the following average daily doses:

• children - 30 mg / kg / day (better to use syrup);
• adolescents and adults - 20-30 mg / kg.

This daily dose is recommended to divide as follows:

• Patients under the age of 1 year - 2 admission;
• patients older than 1 year - 3 receptions.

Double dosing spoon complete syrup designed to 200 mg, small - 100 mg. Eat only medication recommended by a special dosing spoon.

Before that the patient was taking anti-epileptic drugs, which must be replaced Depakine, this should be done gradually, for about two weeks.

If other antiepileptic drugs were not taken, the dosage is increased every 2-3 days, then the optimal dose is reached in about a week.

Overdose

Overdose is fraught with the emergence of drug Coma   varying degrees, which accompanies muscle hypotonia . hyporeflexia . respiratory depression . The likelihood of an intracranial hypertension   due to swelling of the brain.

In case of overdose gastric lavage is performed, the control of the cardiovascular and respiratory systems, as well as osmotic diuresis . In particularly severe cases, dialysis   or exchange transfusion. At high doses, it can even be fatal.

Cooperation

To combine the drug with other drugs that cause seizures or reduce seizure threshold, is strongly discouraged. These include many antidepressants . Mefloquine . Tramadol . neuroleptics . Bupropion . Additionally, contraindicated while taking Depakine with St. John's wort. Not recommended combinations with Lamotrigine .

Especially with caution and under strict medical supervision combine the drug with:

• Carbamazepine ;
• Carbapenems ;
• Monobactams ;
• Felbamate ;
• Phenobarbital ;
• Primidone ;
• Phenytoin ;
• Topiramate .

Together with Nimodipine   drug enhances its hypotensive effect .

Terms of sale

The drug is released only by prescription.

Storage conditions

Store this medication should be in reach of children is well protected from sun better. The temperature is not above 25 ° C.

Shelf life

Keep Depakine need no more than 3 years.

Reviews for Depakine

Reviews for Depakine reported that the drug has a positive effect on mood and mental state of the patients, thus it has an effective antiarrhythmic action .

In addition, those who take it, say such common side effects as fatigue . depression . psychosis . irritability   and so on. Doctors recommend to strictly follow the instructions for use of the drug, while the undesirable symptoms can be avoided. In general, reviews of syrup for children and adults, even though there were some side effects, positive.

Price Depakin where to buy

Price Depakin in Russia is about 330 rubles. Analogs in the form of tablets, usually are more expensive. Price Depakin in Ukraine - about 40 hryvnia.