Description overdue on 12.07.2012

Anticholinesterase agents.   Active ingredient - rivastigmine . The main component is a selective (selective) inhibitor of acetylcholinesterase in the brain. The mechanism of action is aimed at preventing the destruction of acetylcholine , Facilitation of the cholinergic transmission, the selective enhancement of acetylcholine levels in hippocampus and cerebral cortex. The drug has a positive effect on the recovery of the cognitive processes that are celebrated in Alzheimer's disease. Blockade cholinesterase marked slowing of the formation of fragments of the protein beta-amyloid precursor protein, which is involved in the process amyloidogenesis , And hence the formation of amyloid plaques, which are the main evidence-pathological features of Alzheimer's disease. Exelon available in capsule dosage form, as a solution.

Indications, contraindications:

Exelon is prescribed for Alzheimer's disease (mild to moderate severity Dementia ). The drug is not used during breastfeeding, hypersensitive rivastigmine. At broncho-obstructive syndrome , Arrhythmias, sick sinus syndrome, ulcerative lesions of the digestive system, pregnancy, renal colic, urinary tract spasms, epilepsy Exelon used with caution.

Side effect:

Diarrhea, dizziness, allergic reactions, disturbance of appetite, drowsiness, headache, fatigue, tremor, weight loss, increased perspiration , Depression, agitation, asthenia Vomiting.

Overdose:

Manifested diarrhea , Vomiting, nausea. Antiemetics assignment is required, intravenous atropine sulphate 0 in the initial dose, 03 mg / kg. Further dosing is performed depending on the effect.

Mode of application:

Exelon capsules taken twice a day during a meal inside. The first two weeks of treatment, patients receive 1, 5 mg rivastigmine on reception. In case of registration of good portability (approximately two weeks), the dosage is increased to 3 mg, then to 6 mg (double dose). Maintenance Dosage: 1, 5-6 mg twice daily. At night you can not take more than 12 mg. Patients with high sensitivity to cholinergic therapy with medicines Exelon initially 1 mg twice a day.

Special instructions:

As a result, the cholinergic stimulation may increase the secretion hydrochloric acid   in the stomach. Appointment during child bearing is carried out taking into account the possible risk to the fetus. Severity of adverse events during therapy with the selection of doses of rivastigmine can vary or completely disappear after missing a few doses.

Drug Interactions:

Exelon improves   muscle relaxants   depolarizing effects during general anesthesia. Illegal assignment to other m-holinostimuliruyuschih medicines.