Description overdue on 31/03/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Grandaxinum
• Contraindications
• Side effects
• Instructions for use Grandaxinum (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Active ingredient - Tofisopam In 1 tablet contains 50 mg tofizopama. Excipients: magnesium stearate .   talc . stearic acid . gelatin . MCC . potato starch .   lactose monohydrate .

Product form

The drug Grandaxinum (INN - Tofisopam) is available as tablets of 50 mg in blister pack contains 10 tablets in a carton is 2 or 6 blisters.

Tablets white or grayish color, flat, have the risk on one side, almost odorless.

Pharmacological action

In the annotation to the drug indicates that the drug has anksioleticheskoe action.

Pharmacodynamics and pharmacokinetics

The drug is a tranquilizer from the group of benzodiazepine , Eliminates many forms autonomic disorders . Grandaxinum also has a stimulating activity. The drug can be used for patients with myasthenia   and myopathy . It does not cause any physical or psychological dependence or withdrawal. It refers to the day anxiolytics .

Rapidly and almost fully absorbed into the bloodstream from the gastrointestinal tract when taken orally. After 2 hours, reached a maximum concentration in blood. The half-life is 6-8 hours Grandaxinum. About 60% is excreted in the urine, and the rest - with the feces.

Indications Grandaxinum

From what Grandaxinum pills? Here are the indications for use of the drug:

• premenstrual syndrome ;
• disorder of mental adaptation ;
• alcohol withdrawal syndrome ;
• menopause ;
• cardialgia ;
• myopathy .   myasthenia ;
• neurogenic muscular atrophy As well as other disease states (if anxiolytics with myorelaxant action contra);
• neuroses ;
• neurosis-like states (emotional stress, anxiety, autonomic dysfunction, apathy, feelings, reduced activity).

Just discharged when Grandakcin IRR   ( vegetative-vascular dystonia ).

Contraindications

The drug is forbidden to take in the following cases:

• Hypersensitivity to any component of the formulation;
• 1 trimester, lactation ;
• psychomotor agitation, aggressiveness, depression ;
• decompensated respiratory insufficiency ;
• syndrome, respiratory arrest (in a dream).

The drug should not be administered concurrently with the reception of sirolimus . tacrolimus . cyclosporine .

The drug contains lactose monohydrate, so it is not recommended for patients with galactose intolerance , from congenital lactase deficiency As well as to patients suffering glucose malabsorption   and malaktozy .

With care use in patients with:

• acute respiratory failure ;
• epilepsy ;
• closure glaucoma ;
• decompensated chronic respiratory distress ;
• organic brain lesions   ( atherosclerosis   and etc.)

Side effects

In making Grandaxinum may have side effects such as:

• constipation .   nausea . decreased appetite .   dry mouth . gassing , in some cases - congestive jaundice ;
• insomnia . headache , Irritability, agitation, epileptic patients may begin   seizures . confusion ;
• itch .   rash   (including scarlatiniform);
• pain and muscle tension;
• difficulty breathing.

Instructions for use Grandaxinum (method and dosage)

The drug is taken by mouth. The size of the dosage is set individually depending on the overall condition of the patient, the individual tolerability and clinical forms of the disease. Adults usually prescribed 1-2 tablets a day (50-100 mg.) 3 times a day. At irregular consumption dose set at 1-2 tablets.

The maximum allowable dose a day - 300 mg.

Instructions for Grandaxinum   old people   (65) and patients with renal failure : Daily dose of drug intake is reduced by 2 times.

Before taking the medication, you should consult with your doctor.

Overdose

In case the amount in doses of 50-150 mg / kg may be reducing the effects of the central nervous system. Such a dose can cause vomiting . whom . respiratory depression . confusion . seizures .

If symptoms of overdose should not induce vomiting. It is necessary to wash out the stomach, take Activated carbon Which reduces the absorption of substances applied symptomatic treatment.

In case of respiratory depression is carried out IVL Should not enter the central nervous system stimulants.

If hypotension recommended / IV fluids, movement of the patient in Trendelenburg position . If these measures do not lead to normalization of pressure, type norepinephrine   or Dopamine .

Cooperation

Simultaneous with the adoption Grandaxinum tacrolimus . cyclosporine . sirolimus   forbidden.

In making Tofizopama with medications that suppress the central nervous system ( sedative . hypnotic . analgesics . antipsychotic . antidepressants , Means general anesthesia, and others.) Enhanced their sedative effect.

Nicotine . alcohol . protivoelpilepticheskie funds . barbiturates   may accelerate the metabolism, resulting in lower concentrations of the drug in the blood and decrease its therapeutic effect.

Part antifungals   (such as   itraconazole   and ketoconazole ) Can slow the metabolism of the drug and lead to an increase in its concentration in the blood.

Such as the anti-hypertensive drugs calcium channel antagonists   and klonedin   can enhance the effect of the active substance Grandaxinum.

Terms of sale

In different countries Grandaxinum by prescription or not. In Russia and Ukraine the drug without a prescription is not for sale.

Storage conditions

Keep the medication should be in a place which is inaccessible to children at temperature not exceeding 25 ° C.

Shelf life

5 years.

Cautions

More often than other patients, adverse effects may occur   elderly . in patients with mental retardation , Sufferers impaired renal function   or liver .

Tofisopam not be used in Phobias . chronic psychosis   or obsessive-compulsive disorder As may increase the risk of suicide attempts and aggressive behavior.

Grandaxinum does not affect the ability to concentrate and focus, so it can be used while driving and work that require high-speed physical and mental reactions.

Analogs Grandaxinum

Analogs of the drug:   Afobazol . Gidazepam . Diazepam . Neurol . Ì . Tazepam . Phenazepam .

Is it better or Grandaxinum Afobazol?

Both drugs have the same indications for use, but the Afobazalo fewer contraindications and side effects. Regarding the therapeutic effect that the two drugs have a sedative effect and reduces anxiety in patients. Before you start taking Grandaxinum Afobazol or consult a doctor.

Alcohol and Grandaxinum

Alcohol reduces the effectiveness of any drug, so compatibility with alcohol Grandaxinum impossible. Simultaneous use increases the load on the liver, as well as increases the likelihood of side effects.

Reviews Grandaxinum

Testimonials : The competent Dosage and application of the drug, it has a positive effect with minimal side effects.

Reviews doctors Grandaxinum : This drug is often prescribed by doctors for nervous disorders, it has a sedative effect and helps relieve anxiety and tension.

Patients notice the positive effects of taking the drug, which occurs about a week after the start of the course. As many point out the manifestation of side effects such as drowsiness, dizziness, and weakness.

The product effectively eliminates one of the most frequently encountered in menopause   symptoms: a neurotic disorder.

Wikipedia information about this preparation is not, but you can find an article on the active substance - tofizopame.

Price Grandaxinum where to buy

The price of the tablet Grandaxinum in Russia is: packaging of 20 tablets - 220-260 rub., Packing 60 tablets - 475-538 rubles. Buy in Moscow medication at any pharmacy in the presence of a prescription from a doctor.

Price in Ukraine: the cost of the package of 20 tablets - 150 UAH., Packaging 60 tablets - 215 UAH.

Here are the average prices of medicine to know how much exactly Grandaxinum in your region, you must apply directly to the pharmacy.