Description overdue on 08/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use imovan (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The active ingredient of the drug - zopiclone . Additional components: wheat starch, lactose, magnesium stearate, calcium hydrogen phosphate dihydrate, sodium starch, hypromellose, titanium dioxide, polyethylene glycol.

Product form

The drug is sold in tablets.

Pharmacological action

Sleeping pills a means of.

Pharmacodynamics and pharmacokinetics

The drug belongs to tsiklopirrolonam . This hypnotic drug. It acts as a special agonist   receptors. The drug prolongs sleep, reduces the incidence of nighttime awakenings, and improves the quality of sleep.

The drug is rapidly absorbed . The reception, the floor and the number of receptions of the absorption is not affected. The maximum concentration is reached after 90-120 minutes. Bioavailability   - 80%.

The drug is rapidly distributed from vascular bed . The degree of connection with plasma proteins - about 45%.

Reduced plasma concentrations in the range of three dosages, 75 mg -15 not dose-dependent. Half-life of about 5 hours.

Imovan metabolized   in the liver to form metabolites : N-oxide   and N-demethylated derivative . Write mainly in the form metabolites . Approximately 80% - with the kidneys, about 16% - with the feces.

Indications

The drug is used in situational, chronic and temporary insomnia   patients adulthood.

Contraindications

It is impossible to to apply a preparation at elevated sensitivity to its components, aged up to 15 years and decompensated respiratory failure .

Side effects

Adverse reactions have individual character, they depend on the dose and individual sensitivity of the person to the drug. The most common side effect observed a bitter taste in the mouth. Furthermore, the following reaction may occur:

• CCC - palpitations;
• systemic effects - hypotonia, chills, Sweating . asthenia Fatigue;
• organs of vision - diplopia . amblyopia ;
• GIT - coated tongue dyspepsia , Dry mouth, diarrhea . anorexia , Bad breath, nausea, vomiting, constipation , Increased appetite;
• metabolism - weight reduction;
• skin - skin rash, sweating, toxic epidermal necrolysis . itch . Stevens-Johnson syndrome . erythema multiforme . In case of these symptoms should stop taking the drug;
• the immune system - hives . anaphylactic   reaction angioedema ;
• respiratory system - dyspnea . breathlessness ;
• musculoskeletal system - heaviness in the limbs, muscle weakness.

In laboratory tests well as in rare cases can be observed increase in the level transaminases   and / or levels of alkaline phosphatase .

In rare cases, the reported seizures.

In patients in old age may appear heart palpitations, anorexia , Excited state, tremor , Vomiting, sialoreya , A sense of anxiety.

In clinical studies, documented cases of anger and behavioral disorders, which are caused by amnesia .

After discontinuation of the drug possible rebound insomnia , Anxiety, sweating, confusion, palpitations, delirium , Irritability, muscle pain, tremor . agitation . headache . tachycardia Nightmares. In severe cases may appear derealization . hyperacusis , Hypersensitivity, depersonalization, numbness or tingling in the limbs, hallucinations .

Instructions for use imovan (Method and dosage)

The course of use of the drug as possible to be short-lived. Instructions on imovan recommends to take it right before bedtime. Treatment situational insomnia lasts 2-5 days at temporary insomnia   - 2-3 weeks. With Chronic insomnia   course duration is determined individually.

Instructions for use imovan reports the following dosages:

• patients and 65 - 7 5 mg per day;
• patients 65 years - the initial dosage of 3 to 75 mg per day, which increases in case of need.

In case of presence problems with work liver and respiratory failure   Dosage - 3, 75 mg per day.

Overdose

Use of the drug in high doses can be life threatening, especially with simultaneous use of several CNS depressants (including alcohol).

Main manifestations overdose - oppression CNS, what causes drowsiness   or even whom . With a small overdose can be confusion or lethargy. High doses can lead to ataxia . hypotension , Respiratory depression, hypotonia . methemoglobinemia And sometimes fatal.

If after an overdose of less than 60 minutes, the patient can cause vomiting, in other cases, a gastric lavage. Also useful is reception of activated carbon, to reduce the degree of absorption of the drug.

It is advisable to observe the work of the heart and respiratory systems. It may help the introduction of Flumazenil .

Hemodialysis   It is not advisable, as the active ingredient of the drug is characterized by a large volume of distribution.

Cooperation

Do not take in combination with Imovanom drugs that have a depressing effect on the nervous system, namely derivatives Morphine . sedatives . neuroleptics .   barbiturates . tranquilizers . Clonidine   and so forth. Receiving simultaneously   Clozapine   increases the likelihood of respiratory and cardiac function. In addition, during the course of treatment can not drink alcohol and alcohol-containing agents. The combination and imovan Erythromycin   causing an uncontrolled increase in action zopiclone .

Terms of sale

Vacation imovan made from pharmacies by prescription. The drug is assigned a specialist. Buy without a prescription should not be the tool.

Storage conditions

Store means you need at 25 ° C in a dry place, away from children.

Shelf life

Three years.

Analogs imovan

Analogs imovan in pharmacies are manufactured as follows:

• Zopiclone;
• Zopiclone-Acq;
• Normason;
• Piklon;
• Somnol;
• Sonnat;
• Sonovan.

Reviews on imovan

Reviews Imovane forums show the effectiveness of the medication. Patients report about how, that when short courses of the drug has a positive effect. The effect of the drug is noticeable fast, addictive missing.

Reviews on imovan about the side effects reported rarely. Patients say the iron taste and a feeling of bitterness in the mouth. There are cases where after the drug appearing nightmares.

Price imovan where to buy

Often on the forums are wondering where to buy imovan in Moscow, in St. Petersburg and other Russian cities. Means you can get in the network of pharmacies by prescription, but in any online pharmacy you can not find it, as it is released only when the appointment of a specialist.

Buy over the counter medications can cost about 270 rubles. In some cities imovan price may be lower, for example, 260 rubles. In Ukraine, means more expensive. Average price imovan - roughly 100 hryvnia.