Description overdue on 09/11/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Negrustina (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The composition of one capsule means Negrustin   includes 0 425 g herb St. John's wort extract, dehydrated .

Also, it contains additional ingredients: MCC, lactose, aerosil, calcium dihydrogen phosphate, talc, gelatin, magnesium stearate, copper complexes of chlorophylls, sodium lauryl sulfate, iron oxide, titanium dioxide, water.

Part solution Negrustin   as active ingredient include extract of the herb St. John's wort .

And it contains additional components: 1, 2-propanediol, glycerin, sorbitol, flavoring.

Product form

The tool is available as a solid opaque Gelatin capsules , Which have matt red body and green cap. The capsules contain green-brown or gray-brown granules having a specific smell. The tablets are packed into blisters of 10 pieces in the carton packs can contain 3, 4, 6 or 10 blisters.

The solution for internal reception   has brown or reddish-brown color, it is transparent, has a pleasant aroma. If the solution is stored for a long time, it can be observed turbidity or sediment. The solution is packaged in bottles of dark glass by 50 ml or 100 ml. The bottle is packed in a cardboard box, which also contains a measuring cup.

Pharmacological action

Negrustin has sedative influence on the body, has anti-depressant and anxiolytic activity. It means acting on the central and autonomic nervous system.

St. John's Wort affects the enzyme monoamine oxidase   (Type A and B), inhibiting their activity. Therefore, during treatment in humans has not been a drop of neurotransmitter levels, as it occurs in depressive states.

Level neurotransmitters   during treatment Negrustinom rises to optimum performance. Bioflavonoid means structure provides a light calming effect. As a consequence, the treatment of drug increases the overall mood disappear trouble falling asleep, increased appetite, increased efficiency.

Pharmacodynamics and pharmacokinetics

Influence Negrustina defines the cumulative effect of all components that are part of this facility.

Indications

Negrustin indicated for use in the following conditions and diseases:

• asthenia ;
• sense of fear;
• depression   hypochondriacal nature;
• light and medium form of depression;
• anxiety ;
• manic-depressive states;
• great excitement that accompanies itching of the skin;
• excitation manifestation of pain.

Contraindications

Do not use Negrustin if the patient are the following conditions and diseases:

• severe depression;
• endogenous depression;
• photodermatitis ;
• pregnancy   and feeding ;
• High sensitivity to the product;
• reception MAO inhibitors ;
• therapy cyclosporine . digoxin ;
• treatment with drugs, which can be marked unsafe interaction.

Side effects

If the patient uses the pill or solution Negrustin, he may experience the manifestation of these adverse effects:

• eczematous rash on the skin;
• hives Strong itchy skin ;
• manifestations asthenia ;
• anorexia ;
• dry mouth;
• headache ;
• nausea, epigastric pain;
• strengthening of sensitization to household allergens;
• Iron-deficiency anemia .

Instructions for use Negrustina (method and dosage)

Instructions on Negrustin provides capsules and oral solution. The day the patient is assigned to receive one capsule or 1 ml three times a day.

Teenagers aged 12 to 16 years assigned to receive 1 or 2 capsules per day. Instructions for use Negrustina provides that the maximum daily can take 6 capsules or 6 ml of solution Negrustina.

It is advisable to take the drug during meals. The capsules should not chew, they need to drink a small amount of water. The course of treatment should last at least 4 weeks, treatment may continue for a maximum of two months. If there is such a need, the patient can be assigned an additional course of treatment again.

Overdose

There are no clear data on cases of overdosing Negrustina. When taking an overdose of funds may increase the manifestation of the side effects described above. If the patient has tried too large dose, he should avoid staying in the sun for 1-2 weeks.

Cooperation

There easing steps Negrustina when concomitantly with Indinavir . Protease inhibitors . Digoxin . Cyclosporine . indirect anticoagulants . Amitriptyline . Theophylline . Nortriptyline .

If the patient is taking other Negrustin drugs-antidepressants , There may be a strengthening of adverse events, in particular, psychomotor agitation, feelings of fear, nausea and vomiting.

At simultaneous reception and Negrustina photosensitizing drugs there may be a strengthening of photosensitivity.

Simultaneous treatment Negrustinom and application oral contraceptives   could provoke a manifestation of bleeding.

Terms of sale

Pharmacies vehicle sold without a prescription.

Storage conditions

Store the capsule and the solution should be at a temperature not exceeding 25 ° C.

Shelf life

The capsules can be stored for 3 years. The solution - 4 years.

Cautions

In the process of treatment should not be a long time in the sunlight. This caution is especially true of people who have light skin.

You do not need to allow simultaneous reception of other drugs that cause photosensitization .

In view of the presence in the Negrustina sorbitol   bear in mind that every time you receive funds in the body receives about 121 mg sorbitol .

If the solution is assigned to people affected diabetes You need to consider that 1 ml of 0.01 corresponds to HEH.

Caution is assigned to those who have diagnosed fructosemia .

There may be the effect of the drug on the ability to drive vehicles and operate the exact mechanism, especially if Negrustin was adopted simultaneously with alcohol.

Analogs

Analogs Negrustin drug - this means having a structure similar to the active substance. Today in pharmacies can obtain the following analogues: Despres . Gelarium Hypericum . Despres Forte . Gerbion Hypericum . Neyroplant . Doppelgerts Nervotonik . Novoimanin . Life 600 .   Hypericum perforatum extract . Life 900 . Turinervin . Hypericin . dry extract of St. John's Wort . Before you replace Negrustin other means, it is necessary to consult a specialist.

Babies

Children under 12 years of age, the means is not appointed, as there are no clinical data on its use.

During pregnancy and lactation

Data about the harmful impact of the health of the fetus and mother during pregnancy   not, however, be appointed Negrustin pregnant nursing   only if the doctor decides that the benefits of treatment exceeds the potential risk.

Reviews on Negrustin

Reviews Negrustine on forums and sites often leave people who were long course of treatment. There are both positive comments and negative opinions on the lack of efficacy in the treatment of this tool. There are a number of comments indicating that Negrustin a positive effect on mood, helps overcome anxiety. Since taking Negrustin, reviews of doctors should also be taken into account. Experts in the network is strongly recommended not to practice such treatment without purpose, since there are so many cases of uncontrolled receiving funds.

Price Negrustina where to buy

Negrustin in Moscow can buy at an average price of 200 rubles per pack of 30 capsules or 50 ml bottle.

Price Negrustina in Ukraine is 100 UAH. per package or bottle.