Description overdue on 10/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Pantogam
• Contraindications
• Side effects
• Instructions for use Pantogam (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Synonyms
• Babies
• Newborns
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

INN (International Nonproprietary Name) - Hopantenic acid.

Tablets Pantogam

1 tablet comprises 250 mg or 500 mg Hopantenic acid   - Active substance.

Auxiliary ingredients respectively the weight content of the active substance:

• 3, 6, or 1 mg, 2 mg -   calcium stearate;
• 0, 8 mg or 1 mg of 6 - methylcellulose;
• 9, 3 mg or 18 mg of 6 - talc;
• 46, 8 mg - 93 mg of 6 - magnesium hydroxycarbonate.

Syrup Pantogam

1 vial contains 10 g / 100 ml Hopantenic acid   - Active substance.

Auxiliary ingredients:

• 15 g - sorbitol;
• 25 g of 8 - glycerol;
• 0, 1 g - citric acid monohydrate;
• 0, 05 g - aspartame;
• 0, 1 g - sodium benzoate;
• 0, 01 g - food flavoring "Cherry 667";
• to 100 ml - purified water.

Product form

Pantogam drug release in the form:

• spigot white tablets of 250 mg or 500 mg, with a mark and chamfered, 50 tablets in the pack;
• syrup, colorless or slightly yellowish, with the smell of cherry, 1 bottle of 100 ml pack.

Pharmacological action

Nootropic.

Pharmacodynamics and pharmacokinetics

The medicine Pantogam possesses the spectrum of action, caused by the presence in its structure neurotransmitter GABA . Directly affects the GABA (subtype B) receptor channel complex. Exhibits   anticonvulsant and nootropic activity It increases the resistance of the brain to the toxic effects and hypoxia.   In neurons activates anabolic processes, reduces the excitability of the motor, stimulates physical performance and mental activity of the organism, combines moderate sedation with a mild stimulating effect.

If alcohol intoxication chronic nature, as well as the rejection of alcohol improves   GABA metabolism.   It manifests the ability of to the oppression of acetylation reaction That participate in the mechanism inactivation of sulfonamides, and procaine (Novocain) , Whereby prolonged   their action. It prevents abnormal increase cystic reflex   and strengthening the tone of the detrusor.

When taken orally Hopantenic acid   rapidly absorbed from the gastrointestinal tract, it has the ability to pass through BBB It creates the highest concentration in the walls of the stomach, liver, skin and kidney.

It can not be metabolized and excreted for 2 days in an unmodified form. Since feces output 28, 5 and 67% drug, 5% in the urine.

Indications Pantogam

Indications Pantogam tablets for adults and children from 3 years:

• cognitive impairment with neurotic disorders , And also owing organic brain damage (including head injuries and the consequences neuroinfections);
• extrapyramidal pathology (hepatolenticular degeneration, Parkinson's disease, myoclonus epilepsy, Huntington's chorea etc. . );
• cerebrovascular insufficiency provoked atherosclerotic vascular abnormalities in brain structure ;
• prevention, as well as conducting therapy extrapyramidal syndrome (akinetic, hyperkinetic) by reason Reception of neuroleptics;
• epilepsy, flowing with inhibition of mental processes (appointed in conjunction with the action of anticonvulsant drugs);
• psycho-emotional to Be Excessively load, lowering of of physical working capacity and mental activity, to improve memory and attention span;
• neurogenic changes   during urination   (enuresis, frequent urination, imperative incontinence, urgency);
• organic cerebral insufficiency in schizophrenia;
• children from 3 years prescribed pills when Pantogam perinatal encephalopathy, mental retardation of varying severity, delayed motor, speech, mental development or a combination thereof.   Also in various forms of Cerebral palsy, neurosis pathologies (tics, stuttering), hyperkinetic forms   (hyperactivity when there is a lack of attention).

Indications Pantogam children at birth, in the form of syrup:

• perinatal encephalopathy   (assigned at birth);
• Cerebral Palsy   different forms of gravity;
• retardation varying degrees of severity, including behavioral disorders;
• pathology psychological status (mental retardation or physical specific pathology motor function, speech, as well as their combination);
• development of the of school skills in children (writing, reading, counting, etc.);
• senile dementia in primary forms;
• hyperkinetic deviations, including the syndrome of attention deficit hyperactivity;
• lowering mnestiko-intellectual activity due to arteriosclerotic vascular pathology of the brain;
• trauma, toxic exposure or neuroinfec-   on the brain;
• neurosis-like states   ( stuttering, inorganic encopresis, tics );
• cerebral organic pathology in schizophrenia   (in a complex with psychotropic drugs );
• extrapyramidal diseases   (Parkinson's disease, Huntington's syndrome, hepatolenticular degeneration, myoclonus epilepsy, etc.);
• therapy and prevention of extrapyramidal syndrome, due to receiving antipsychotics;
• reduction of efficiency,   both physical and mental, psycho-emotional overload, in order to improve memory and concentration;
• epilepsy   with inhibition of mental processes and reduced cognitive efficiency (in combination with anticonvulsants);
• neurogenic bladder disorders etiology.

Contraindications

Abstract on drug Pantogam indicates the following contraindications to its use.

For tablets:

• the patient's age up to 3 years;
• period breast-feeding ;
• period pregnancy .

For syrup:

• first trimester of pregnancy;
• phenylketonuria,   because of the content Aspartame syrup in the composition.

General:

• hypersensitivity to hopantenic acid or other ingredients of syrup or tablets;
• acute renal disease in a severe form.

Side effects

Typically, therapy with Pantogam passes without serious complications.

There may be side effects in the form allergic reactions (rash on the skin, conjunctivitis, rhinitis) . In this case, reduce the dose or cancel Pantogam therapy with its use.

Also observed noise in the head, phases of sleep disorders or daytime sleepiness.   These symptoms usually do not require discontinuation of therapy and are transient.

Instructions for use Pantogam (method and dosage)

Pantogam medicine in the form of syrup and tablets administered orally (p.o.) after meals, after 15-30 minutes.

The preferred time of reception - up to 16 hours of the day.

Tablets Pantogam, instructions for use:

Pantogam recommended single dose in the form of tablets for adults - 250 mg - 1000 mg, the daily dosage is equal to - 1500 mg - 3000 mg.

Babies with 3 years prescribed tablets in a single dose of from 250 mg to 500 mg, the daily dosage is equal to - 750 mg - 3000 mg.

The course of treatment typically takes from 30 to 120 days, in some cases up to six months. After 3 or 6 month break, you can spend a second course of treatment.

In the combination therapy of epilepsy   Pantogam administered in a daily dose of 750 mg - 1000 mg, for a year or more.

At the combined the treatment of extrapyramidal neuroleptic syndrome   take up to 3 grams of the drug, for several months.

During the combination therapy of extrapyramidal hyperkinesis in patients with hereditary disease states of the nervous system , Recommended daily dose of 500 mg to 3000 mg, for up to 4 months or more.

To mitigate the effects of brain injury and neuroinfections   - On 0, 25 g (250 mg) with reception Pantogam 3 - 4 times a day.

To resume performance in states of fatigue and excessive loads   - 3 times per night on 250 mg.

For the treatment of extrapyramidal syndrome, because of receiving neuroleptics Recommend to adult patients at 500 mg - 1000 mg, three times a day; recommended dosage for children - from 250 mg to 500 mg in 3-4 hours. Treatment lasts from 1 to 3 months.

Children with tics administered 3-6 times per day in a dose of 250 mg to 500 mg, for from 1 to 4 months.

When violations of in the process of of urination   Adult patients take pills Pantogam 2-3 times during the day at 500 mg - 1000 mg; pediatric patients on 250 mg - 500 mg (recommended daily dose ranges from 25 mg to 50 mg per kilogram of body weight). The course of treatment is carried out for the 1 st - 3 months.

Depending on age, children with various diseases of the nervous system, administered from 1 to 3 g Pantogam.

The dosage regimen often boils down to capacity dose for 7-12 days, followed by a reception Pantogam maximum dose for 15-40 days, with a slow decline in the maximum dose (7-8 days) to the full withdrawal of the drug.

If necessary, re-treat, a break must be from 1 to 3 months.

Syrup Pantogam, instructions for use:

Adult patients administered a single dose of 250 mg - 1000 mg, the daily dosage equal to 1500 mg - 3000 mg.

Children from 0 month recommended a single dose of 250 mg - 500 mg daily dose is equal to 750 mg - 3000 mg.

Therapy is conducted for from 1 to 4 months, at least up to 6 months. Reappointment Pantogam possible after a break of 3-6 months.

The recommended daily dose range for the children, depending on the pathology and the age of:

• from 0 to 12 months - 500 mg - 1000 mg;
• up to 3 years - 500 mg - 1250 mg;
• from 3 to 7 years - 750 mg - 1500 mg;
• older than 7 years - 1000 mg - 2000 mg.

Tactics of treatment recommended by escalating daily dose for 7 -12-day, followed by a reception for a maximum dose of 15 - 40-days or more, with a gradual reduction of the dose (7-8 days), before drug withdrawal . The course of treatment is 30 to 90 days (in the treatment of some diseases up to 6 months or more).

In the combination therapy of epilepsy with parallel receiving anticonvulsants   administered 750 mg - 1000 mg per day. The treatment lasts for 12 months or more.

In the combined treatment of schizophrenia with a joint reception of psychotropic drugs   Recommend 500 mg-3000 mg per day, with a course of treatment from 30 days to 3 months.

In the treatment of neuroleptic syndrome, with concomitant extrapyramidal violations of,   take the daily dose is up to 3,000 mg of syrup. The therapy is carried out for several months.

In therapy, and the effects of TBI neuroinfections   administered in a daily dosage of from 500 mg to 3000 mg.

When extrapyramidal hyperkinesis, for the treatment of patients with organic disease of the nervous system,   Recommend daily dose syrup from 500 mg to 3000 mg. The course of therapy makes up to 4-x months and more.

Admission syrup to restore the operability of fatigue and excessive loads   carried out three times a day in a dose of 250 mg - 500 mg.

  Children with disorders of urination   prescribed 250 mg - 500 mg, with a daily dose equals - 25 mg - 50 mg per kilogram of body weight. The course of treatment lasts for from 30 days to 3 months; for adults shown the intake syrup 2-3 times per night, on 500 mg - 1000 mg.

When conducting long-term therapy is not recommended concurrent prescribing of drugs with the same effect.

Overdose

In case of overdose pantogam probably intensifying of symptomatology of his collateral action, in particular: noise in the head, drowsiness, or sleep disturbance.

Recommend carrying out of symptomatic therapy with by washing with of the stomach and the appointment of   activated charcoal.

Cooperation

Pantogam when combines with reception barbiturates   prolong their action.

In a joint application with anticonvulsants   increases their effectiveness.

Prevents side effects Carbamazepine, phenobarbital, neuroleptics.

Potentiates the effects of drugs for local anesthetic (Procaine).

Action Pantogam enhanced by the combined treatment with Etidronic acid and glycine.

Terms of sale

In pharmacies by prescription.

Storage conditions

To be stored at a temperature not exceeding 25 ° C.

Shelf life

Tablets - 4 years.

Syrup - 2 years.

Analogs Pantogam

When looking for alternative medicines can offer you the following analogues Pantogam:

• Vinpocetine;
• Ginkgo Biloba;
• Glycine;
• Cavinton;
• Lutset;
• Cortexin;
• Nootropil;
• Piracetam;
• Cere;
• Tiotsetam;
• Encephabol   and many others.

Synonyms

• Pantogam asset;
• Pantokaltsin;
• Gopantam;
• Calcium gopantenat.

Babies

Pantogam for children in the form of tablets applies only at achievement of 3-x years of age, starting since a birth can be take the drug for children in form of a syrup.

Doctors about Pantogam tablets in the treatment of many neurological diseases in children starting at 3 years old, in 99 cases out of 100 positive. Note the high efficiency of the therapy with minimal side effects. It is worth noting that the drug does not occur immediately, but most often, through 1-1, 5 months after the first dose.

Pantogam side effects are rare in children and usually are in drowsiness or sleep disorders.   It is possible that these symptoms are dependent on the time of administration of the drug, which is not recommended to take after 4 pm.

In the user forums devoted to medicines for the treatment of various children's neurological pathologies, is not a small place is occupied by the discussion
Pantogam drug for children. Guest Reviews Forum when hyperactivity, stuttering, impaired intellectual and physical activity, tics, lack of attention, problems with urination   etc. mainly positive.
Recall that Pantogam in tablet form does not have enough database of clinical trials, as well as physically uncomfortable to receive babies, from which tablets Pantogam not indicated for children up to 3 years.

Newborns

The drug Pantogam for newborns can only assign an experienced pediatrician as their own shortcomings noted child development at this age is very difficult.

Speaking about the effectiveness and appropriateness of prescribing Pantogam for newborns, rather contradictory opinions of parents. Some doctors are grateful for the time the problems detected in the development of own child and point out its further complete the formation of other neglected and advice pediatrician and do not feel any abnormalities.

In any case, even if gratuitous appointment Pantogam syrup formulation exhibits virtually no side effects, and in the case of real problems will certainly help to solve them. After all, price is often the time of taking the medicine may be minuscule compared to the possible negative consequences of inactivity.

During pregnancy (and lactation)

Pantogam drug, in the form of tablets is contraindicated in pregnancy and breastfeeding .

In the form of a syrup do not recommend taking it in the first trimester of pregnancy.

Reviews pantogam

Pantogam tablets for the treatment of various neurological disorders listed in the instructions on the application, receive positive feedback from physicians who use them in their practice. When taken by adults, reviews about pantogam talk about the excellent results of the therapy. 98% of patients are absolutely satisfied with the outcome of treatment and are willing to trust this drug in the future.

Upon receipt of children, opinions about pantogam no less positive, including reviews of the tablets when taking their children to 3 years, as well as reviews of Pantogam syrup for children from 0 months.

For infants reviews of pantogam more diverse and do not come to a definite opinion. The fact is that many parents do not trust their pediatricians, and often do not follow their recommendations, preferring to self and "natural" development of the child. It is worth noting that not infrequently they are right and the formation of a normal baby passes without any drugs.

Put babies correct diagnosis and proper treatment, can only experienced and honest pediatrician. Either way, the decision to hold the baby any medication you are taking, so the approach to this with full responsibility, taking into account the opinion of several doctors and their own intuition.

What better Pantogam or Pantokaltsin?

In fact Pantogam and Pantokaltsin   - Synonyms, ie in their formulation of the active ingredient is the same substance. According to the experts' opinion, the effectiveness and the cost of these drugs is almost identical. In this regard, the interchangeability of these drugs.

Price Pantogam where to buy

The cost of the drug Pantogam depends on its pharmaceutical form (tablets for adults and children older than 3 years, or syrup for children), as well as the region and the pharmacy network.

Buy Pantogam pharmacies in Russia you can average:

• Price Pantogam tablets 500 mg №50 - 550 rubles;
• Pantogam price for children from 3 years in tablets of 250 mg №50 - 350 rubles;
• Price Pantogam syrup for children from 0 months, 10% of 100 ml №1 - 350 rubles.