Description overdue on 08/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Seroquel Prolong (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The chemical composition of the drug Seroquel or Seroquel Prolong depends primarily on the form of the drug. One tablet formulations identified above can contain 25, 50, 100, 150, 200, 300 or 400 mg. Quetiapine   (active substance).

As part of the drug Seroquel are also present, such as the auxiliary connections: dibasic calcium phosphate, povidone, carboxymethyl cellulose, microcrystalline cellulose, lactose monohydrate, sodium carboxymethyl   and magnesium stearate .

Film-coated tablets contain   macrogol 400, dioksid titanium , and hypromellose And, in some dosage forms of the drug present dyes, e.g., yellow or red iron oxide.

As part of the drug Seroquel Prolong addition to the active compound quetiapine   contains auxiliary components such as:   lactose monohydrate, microcrystalline cellulose, sodium dihydrate, magnesium stearate , and Valium . Film-coated tablets contain titanium dioxide, macrogol, yellow or red iron oxide and hypromellose.

Product form

Film-coated tablet Seroquel are distinguished not only by the number contained in the composition of the drug compound, but in color. The manufacturer produces pink tablets - 25 mg. Quetiapine   (10 pcs. In a blister, 3 or 6 blisters per pack), yellow - 100 mg.   of quetiapine (10 pcs. Blistere in, 3, 6 or 9 blisters in multiples) and white - on 200 mg. Quetiapine   (10 pcs. In a blister, 3, 6 or 9 blister pack).

In addition, in one package of the drug may be a combination of different forms of drug release, i.e. 6 tablets contained 25 mg., 3 - 100 mg. and 1 - on 200 mg. On one side coated tablets engraved, which indicates the amount of drug compound contained in the composition of any form of release of the drug - Seroquel 25, Seroquel WO and Seroquel 200.

The drug Seroquel Prolong is also available in tablet form. Depending on the form of the drug release at a special coated film coated biconvex tablet of oblong and the drug may be applied engraved, which corresponds to the number Quetiapine For example, XR50, XR150, XR200, XR300 and XR400. Typically, in one blister pack contains 10 tablets of the drug, as in a carton - 6 blisters.

Pharmacological action

Both drugs are antipsihotropnym drugs and have on the body neuroleptic exposure .

Pharmacodynamics and pharmacokinetics

Since both drugs are a group atypical antipsychotics , They exhibit affinity high degree in relation to serotonin 5HT2 receptor class , compared to dopamine receptors brain D1 and D2 . Analogous properties preparations show in respect   adrenoceptor   and histamine receptors .

During research affinity with both drugs benzodiazepine and cholinergic muscarinic receptors   It has been identified. In conducting standard medical tests show their products antipsychotic properties.   Seroquel Prolong as Seroquel is not expressed catalepsy That entails blocking of dopamine D2 receptors.

Further there selective decrease in activity of of dopaminergic mesolimbic of neurons the A10 compared with those involved in motor function   nigrostriatal neurons . When using both drugs in blood does not increase the level of prolactin. As a result of research experts have discovered the ability of these drugs to deal with the symptoms and effects Schizophrenia .

When administered orally, pharmaceutical preparations compounds contained in them sufficiently rapidly absorbed in stomach e and then actively metabolized   by means of liver . It should be noted that bioavailability of quetiapine   Food does not affect, however both drugs can be administered without food.

As Seroquel Prolong and Seroquel are derived from the human body with faeces , and urine .

Indications

These drugs are indicated for:

• schizophrenia;
• chronic psychosis;
• manic states;
• depression;
• bipolar disorders.

Seroquel Prolong used for preventive purposes, such as to prevent relapse schizophrenic seizures   in stable patients, as well as   Bipolar disorders in patients who had previously successfully passed courses of treatment   quetiapine . Moreover, the drug often include complex treatment of patients with suboptimal response to monotherapy   using Antidepressants .

Contraindications

Both drugs are contraindicated in the presence of individual intolerance in patients of various constituent components of the chemical composition of the drug, as well as   lactase deficiency   or galactose intolerance At malabsorption of glucose and galactose.

In addition, both drugs are contraindicated for children under 18 years. Seroquel Prolong as Seroquel should be taken with extreme caution in elderly patients, people suffering cerebrovascular and cardiovascular ailments   or located in hypotension As well as those categories of patients with a history of the development of the risks described seizures, liver failure, aspiration pneumonia and stroke .

Side effects of Seroquel

Among the most common side effects of Seroquel and Seroquel Prolong the following:

• dizziness;
• drowsiness;
• dispersion;
• constipation;
• a tachycardia;
• dry mouth;
• orthostatic hypotension;
• increase in blood levels of triglycerides in liver enzymes and insulin.

Often, in the first week of using the drug to patients gain weight. Quite rare, however, when taking these drugs may experience side effects such as: convulsions, priapism, neuroleptic syndrome, impaired consciousness, dystonia, vegetative sosudnye disorders neutropenia, akathisia, and leukopenia . With long-term use of the drug may develop tardive dyskinesia .

Instructions for use Seroquel Prolong (method and dosage)

Seroquel Prolong should be taken on an empty stomach, pills do not chew or crush. The dosage and duration of treatment depends on the type and severity of the disease, and, in addition, one should consider the health status of patients. When treating Schizophrenia , and bipolar disorder   should take the medicine according to the following schedule:

• 300 mg. on the first day;
• 600 mg. for the next two days.

The optimum recommended daily dosage of the drug to 600 mg. It can be increased to 800 mg. in the case of acute medical necessity.

During treatment depression   Seroquel Prolong taken as follows:

• 50 mg. on the first day;
• from 100's mg. during the second day;
• Further, 200 mg. for the third day;
• then along 300 mg. throughout of the fourth of the day.

The recommended daily dosage is 300 mg of the drug. It can be increased to 600 mg. for medical reasons, and in the case of normal tolerability patients. As a preventive measure Seroquel Prolong take the night within the dose equal to 300-800 mg.

In the combined therapy in   suboptimal response   patients treated antidepressants   drug taking on 50 mg. the first two days, followed by 150 mg. for another four days.

In accordance with the instructions on Seroquel medication taken twice a day. The dosage regimen for the drug as the duration of treatment depends on the kind of disease and the patient's health.

When treating schizophrenia and psychoses   drug taking:

• 50 mg. on the first day;
• 100 mg. during the second day;
• 200 mg. on the third day;
• on 300 mg. on the fourth day.

The recommended daily dosage of the drug can vary from 150 to 750 mg.

When treating biopolyarnyh disorders And manic-depressive states are taking Seroquel as follows:

• 100 mg. on the first day;
• 200 mg. on the second day;
• on 300 mg. on the third day;
• 400 mg. in the last quarter of the night.

Gradually, the therapeutic dose of the drug to build and to six days can reach 800 mg.

Overdose

It should be noted that in compliance with recommendations for receiving both drugs, cases of drug overdose are rare. However, in some cases, the effects of overdose were so incompatible with the life of the patient, which leads to death or coma.

If you exceed the daily doses of drugs may experience symptoms such as: drowsiness, reduced pressure, excessive sedation And, moreover, tachycardia.   In severe intoxication   symptomatic treatment, as well as measures aimed at maintaining cardiovascular and respiratory systems   human body.

Cooperation

Increased concentration Quetiapine And, consequently, increasing the efficiency of both drugs may occur while taking Seroquel and Seroquel Prolong with antibiotics Belonging to Groups macrolides As well as azole antifungals . Dosage adjustment of drugs may also require the simultaneous use of drugs with medicinal products containing a part of phenytoin   or designed to induce hepatic enzymes , eg, Carbamazepine.

Terms of sale

Supply of pharmacies by prescription only.

Storage conditions

Store Seroquel Seroquel Prolong and can be at a maximum of 30 ° C, thus out of reach of children.

Shelf life

3 years.

Cautions

When transferring patients on the drug Seroquel Seroquel Prolong use the same daily dosage, though declining number of medication. However, in some cases, you may require a dosage adjustment, as well as the plan of taking the pills. When using both drugs in the treatment of elderly patients should be started at a reduced daily dose (25 mg.).

Because among the side effects of both drugs is present drowsiness   should not drive a vehicle or operate potentially dangerous machinery units and during treatment with these preparations.

Analogs of Seroquel

It is worth noting that the main analogue of Seroquel Seroquel Prolong considered and vice versa. However, the list of similar drugs that converge in their structure and mode of action with both drugs appear:

• Gedonin;
• Viktoel;
• Quetiapine;
• Kventiaks;
• Quetiapine fumarate;
• Kventiapin Stada;
• Kventiapin hemifumarate;
• Ketilept;
• Lakvel;
• Ketiap;
• Kutipin;
• Servitel;
• Nantarid.

Synonyms

Seroquel

During pregnancy (and lactation)

As a rule, experts do not recommend taking both drugs during pregnancy Because it is not known effects of exposure on fetal development and maternal health Quetiapine . However, in cases where the expected benefits outweigh the possible risk of drugs used in the therapeutic treatment under close medical supervision.

When you receive drugs breast-feeding   should be discontinued.

Reviews of Seroquel

On the forums is possible to meet different reviews of host preparations Seroquel and Seroquel Prolong, since opinions of people were divided. Some praise these drugs, and others - on the contrary, expressed a negative, and about their effectiveness and cost.

Therefore, although many patients leave positive feedback for Seroquel and Seroquel Prolong, a considerable number of patients as the negative side of both drugs noted the extensive list of side effects, as well as too "soothing" and absolutely not the active state when they are used.

Price Seroquel where to buy

Buy both drugs can be in pharmacies by prescription. It should be noted that these drugs are not cheap, for example, the average price Seroquel Prolong 300 mg. (60 tablets in a single package) up to 1100 rubles.