Description overdue on 05/07/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Sindopu (method and dosage)
• Overdose
• Cooperation
• Storage conditions
• Terms of sale
• Shelf life
• Cautions
• Reviews
• Price, where to buy

Composition

Sindopa preparation has the following composition:

• Levodopa   (250 mg);
• carbidopa   (25 mg);
• purified talc, lactose, butylhydroxyanisol Sodium starch glycolate, corn starch, magnesium stearate, cellulose, povidone K30, colloidal silicon dioxide, colorant.

Product form

Valium tablets are shape, color - light pink, there are blotches. On one side of the tablet are two intersecting risks other - engraving Syndopa .

The contour package contains 10 tablets in a carton contains 5 packs.

Pharmacological action

The drug has protivoparkinsonicheskogo   and dopaminergic   action.

Pharmacodynamics and pharmacokinetics

Its structure Levodopa It is an amino acid from which with the help of a cytoplasmic enzyme produced Dopamine . Dopamine, in turn, inhibits the neuronal activity in the striatum of the brain. Dopamine does not cross the barrier gametoentsefalichesky.

The resulting combination levodopa and carbidopa amount of levodopa, which enters the brain increases. Thanks carbidopa bioavailability levodopa doubles. Admission carbidopa can lead to complete inhibition dopa decarboxylase .

Levodopa is absorbed from the gastrointestinal tract. The obstacle is dopa decarboxylase   in the intestinal wall. Food can slow absorption. Maximum concentration in the blood within 1-2 hours. About 69% lovodopy (dopamine and its metabolites) is detected in the urine.

The maximum concentration of carbidopa is noted 2-4 hours. Since feces and urine output of about 50% of the material. Unchanged by the kidneys in 35% yield.

Indications

Sindopa be appointed in the following cases:

• Parkinson's disease ;
• Parkinson's syndrome   (resulting from Encephalitis . intoxication , Cerebrovascular disorders).

Contraindications

The drug is not administered in the following cases:

• heavy   psychosis ;
• skin diseases   of unknown origin;
• secondary parkinsonism   (resulting from receiving neuroleptics);
• pregnancy;
• heavy neurosis ;
• Huntington's disease ;
• sensitivity to the drug;
• essencialny tremor ;
• lactation;
• age 18 years;
• closure glaucoma ;
• melanoma   (suspected melanoma).

Precautions drug should be taken under the following conditions:

• seizures ;
• heart failure ;
• irregular heartbeat;
• renal dysfunction, severe liver;
• diabetes ;
• erosive and ulcerative lesions of the stomach or duodenum;
• myocardial infarction ;
• mental disorders;
• bronchial asthma ;
• diseases of the endocrine system.

Side effects

Side effects:

• Dementia . anorexia . depression , Nervous tension, ataxia , Anxiety, nightmares, euphoria, dyskinesia , Increased libido, insomnia , Alopecia dystonia . hallucinations . gapomaniya . choreoathetosis , Convulsions, irritability, sedation, on-off syndrome (occurs with prolonged use), psychotic reactions, dizziness, drowsiness, paranoid state;
• constipation , Vomiting, dysphagia , Nausea, ulrogennoe action epigastric pain;
• tachycardia . collapse , Orthostatic hypotension, cardiac Arrhythmia ;
• thrombocytopenia . leukopenia   moderate, hemolytic   anemia ;
• mydriasis , Weight gain, nictitating spasm . diplopia .

Taking the drug may affect certain laboratory parameters : Deviation of urea nitrogen, glutamatliruvatoksalazy, iodine, lactate dehydrogenase, bilirubin, glutamatoksalattransaminazy, alkaline phosphatase , A positive Coombs' test.

The degree of side effects depends on the dose and the patient's sensitivity and components. To eliminate their appearance, it is necessary to temporarily lower the dose, without interrupting the treatment. Unless there is a regression of side effects, the treatment should be terminated gradually.

Instructions on Sindopu (method and dosage)

The drug should be taken after meals, inside, drink water and do not chew. During the period of administration of the drug it is recommended to reduce the level of protein intake. Average kabidopy necessary dose per day - 70-100 mg. Taking more carbidopa usilivet no therapeutic effect. The maximum daily dose of levodopa - 2 Years

Treatment must begin with a dose of 0, 5 tablets twice a day. With the necessary dose could be increased on day 0, 5 tablets. Early in the course of severe parkinsonism dose should not be more than three tablets (three times a day one tablet).

Overdose

With an overdose of the drug Sindopa may experience the following symptoms: a sharp increase and then decrease in blood pressure, insomnia . sinus tachycardia , Anxiety, agitation, confusion. Perhaps the development of orthostatic hypotension . Insomnia and anorexia   can last a few days.

As the treatment is necessary to appoint a gastric lavage, followed by the adoption of activated carbon. Under steady-state conditions is possible symptomatic therapy.

Cooperation

When receiving antihypertensives Sindopoy with risk of developing postural hypotension .

There is a probability of occurrence dyskinesia . hypertension As well as reductions in bioavailability when taken with levodopa tritsikticheskimi antidepressants .

Efficiency is reduced when taking Sindopy butirofenonov   and phenothiazines .

Side effects of levodopa may be triggered metidofoy .

Simultaneous with the appointment Sindopoy non-selective monoamine oxidase inhibitors   can lead to hypertensive crisis . Inhibitor therapy should be discontinued 2 weeks before the start of the reception Sindopy.

The drug may cause amplification steps sympathomimetic So when co-administered dose necessary to reduce the latter.

The potentiating effect can be observed when combined lovodopy and amantadine.

The effect of levodopa is reduced with the use of pyridoxine .

Sindopy antiparkinsonian effect can be reduced when taking phenytoin . reserpine . diazepam Derivatives   thioxanthene . papaverine . Mr. holinoblokatorov   and clonidine .

Storage conditions

At a temperature not exceeding 30 ° C in a dark place.

Terms of sale

The tool is sold by prescription.

Shelf life

4 years.

Cautions

Can develop simptomokomleks   (fever, muscle rigidity , Elevated blood CK ) With abrupt cessation of therapy, so treatment should be terminated gradually. It is necessary to monitor the status of patients who have been forced to interrupt reception or drastically reduce the dose.

Older people suck levodopa higher than in younger.

It is necessary to control the function of the kidneys, liver, cardiovascular system and the hematopoietic system, as well as the psychological status of the patient with prolonged treatment.

It is necessary to monitor the intraocular pressure   in patients with glaucoma .

While receiving the drug should not drive a car and do the job that requires attention.

Reviews

Upon receipt of this drug in patients observed a significant improvement in the preparation. Physicians are advised to follow the instructions carefully and take the drug at the designated doses, to avoid the appearance of side effects.

Price Sindopy

In Russia, the price of pellets is about 140 rubles, Ukraine - 55 UAH.