Description overdue on 21.09.2011

The preparation ketotifen   It has a distinct antihistamine effect . This means the group nebronhodilatiruyuschih asthma drugs . Ketotifen operates as follows: it slows down the release of histamine and other mediators from mast cells, as it blocks histamine H1-receptors While inhibiting PDE enzyme. As a result of these actions, in fat cells increases levels cAMP . Ketotifen acts overwhelmingly on the effects of platelet-activating factor. If the drug is used alone, the attacks asthma   not cropped. At the same time, the drug anticipates their appearance and greatly reduces the intensity and duration of these attacks. In some cases, they stop completely. The maximum plasma concentration of the drug observed after 2-4 hours. Metabolization means the greater portion of the dose in the liver.

Indications and methods of use of the drug:

Ketotifen is used as an additional tool in the process of long-term therapy of atopic asthma .  Also, the drug is used during the treatment of a number of allergic conditions, such as rhinitis, conjunctivitis and allergic-type .  Tablets consumed during a meal, washed down with a little water .  One tablet contains 1 mg .  Adults take one tablet twice a day .  Those patients in whom there is a manifestation of the sedative effect should gradually increase the dose .  This is done for seven days, you must start with 0, 5 mg .  It accepted the dose at bedtime and gradually rises to the amount of drug therapeutic dose .  Children older than three years take 1 tablet twice a day - morning and evening .  The drug is similar while eating .  Children from six months to three years old can only take ketotifen syrup .

Treatment takes a long period of ketotifen. This remarkable effect after administration is reached after 2-3 weeks of therapy. The total course of treatment should be two to three months. Especially long period should take the drug in those patients who had no visible effect was observed after a few weeks of ketotifen. Treatment of this tool is stopped gradually over several weeks. This is done in order to avoid recurrence of asthma symptoms .

Contraindications and possible side effects:

Do not use the drug to patients having a high sensitivity to ketotifen or auxiliary components. It prohibited the drug in the first trimester of pregnancy and during breastfeeding. During the treatment with this drug may develop some side effects. Quite often there is a state of drowsiness, dry mouth, increased sleepiness, dizziness. There may be problems with the gastrointestinal tract - constipation , nausea, vomiting. These phenomena disappear spontaneously during treatment. Also referring to the increased appetite may increase the weight. Less commonly, symptoms of irritability and agitation, hypersensitivity. Children may cause seizures. May occur infrequently hepatitis . cystitis . jaundice , Dark color of urine. In case of overdose can occur drowsiness, hypotension , Dizziness, vomiting and nausea, convulsions in children. In this situation urgently needed gastric lavage, and receive symptomatic treatment.

Specific recommendations:

The drug ketotifen not used to to stop asthma attacks . At the beginning of therapy with this agent should not be abruptly stopping treatment other asthma medication. This is especially true systemic corticosteroids . In people with steroid dependence may develop adrenal insufficiency.

In this drug has the property to lower the seizure threshold, thus it carefully prescribed to those patients who have manifested convulsions. During pregnancy, the drug is prescribed only when there is direct testimony, and benefit from taking it outweigh the risks for the woman and the fetus. When receiving the drug should be stopped breast-feeding. In view of the possible manifestations of sleepiness Ketotifenum recommend carefully apply to drivers and people working with potentially dangerous units.

During the period of drug therapy can not drink alcohol because the alcohol greatly increases the depressive effect on the central nervous system. Ketotifen should be protected from moisture and light penetration site, the temperature should not exceed 25 ° C.