Description overdue on 12.02.2012

Allergy medication . Antagonist histamine   competitive action is a product of the metabolism of hydroxyzine, cetirizine act by blocking histamine H1 receptors. Under the action of the drug stops the development of allergic reactions chain, prevent the formation of an allergic response. The drug has antivoekssudativnym and antipruritic effect. Cetirizine has an effect on the very first stage of the chain of the allergic response, reduces the production of inflammatory mediators in the final stages of formation of allergy, slowing migration basophils , Eosinophils, neutrophils. The drug relieves spasms with smooth muscle, prevents the development of edema, reduces the permeability of the capillary wall. With the introduction of allergens, histamine cetirizine prevents and eliminates skin reaction. A similar effect was observed when   cold urticaria . In mild form of bronchial asthma drug relieves gistaminindutsirovannoy bronchoconstriction . It does not possesses the protivoserotoninovym and anticholinergic effects. Therapeutic dose not lead to the formation of sedation. When ESP-of therapy tolerance is not is formed. Cetirizine is available as a solution, drops, syrup, tablets.

Indications and contraindications:

Cetirizine is effectively used with allergic rhinitis, allergic conjunctivitis (perennial, seasonal flow variations). The drug is prescribed for idiopathic urticaria , Skin ulcers, hay fever , Atopic asthma embodiment, angioedema , Dermatitis allergic genesis. Cetirizine is not indicated in case of hypersensitivity to the metabolites of hydroxyzine, breastfeeding, if carrying a pregnancy.

Side effect:

Cetirizine may trigger the development of dyspeptic disorders, increased drowsiness, dryness of mucous membranes of the mouth. Rarely observed urticaria, migraine , Dizziness.

Mode of application:

Cetirizine taken regardless of meals, drops dissolved in water, the tablets washed down with plenty of liquid. The drug is taken once a day, 10 mg - 1 tablet. It is permissible to a partition of dose on 2 admission. In the pathology of renal dose reduced by half, take a day.

Special instructions:

Exceeding the recommended dose leads to a decrease in the ability to fast reactions, lowers your concentration, execution of complex operations. Receiving the recommended dose of the drug did not potentiate the effect of alcoholic beverages on the nervous system. During antiallergic therapy   It recommends to refrain from receiving ethanol.

Drug Interactions:

Pharmacologically and clinically significant drug interaction with diazepam . ketoconazole , Glipizide, azithromycin . erythromycin , Cimetidine, pseudoephedrine were observed. Reception theophylline   It leads to a decrease in drug clearance cetirizine. Myelotoxic drugs while appointing strengthen haematotoxicity   cetirizine.