Description overdue on 08.02.2012

Allergy medication.   Main, the active ingredient - cetirizine It is a metabolite of hydroxyzine. The mechanism of action is based on blocking the histamine H1 receptor, the active ingredient of the drug is a competitive antagonist Zodak histamine . Zodak has protivoekssudativnoe and antipruritic impact, facilitates the allergichesikh reactions, prevents their development. It is based on the influence of the base material at the early stage in the chain of allergic reactions, the drug reduces the migration basophils , Neutrophils, eosinophils, limits the amount of released   inflammatory mediators   already at the final stage circuit of allergic reactions. Cetirizine relieves smooth muscle spasm, prevents the development of tissue edema It reduces the permeability of capillaries. Zodak eliminates skin reaction at cold urticaria When administered to specific allergens, and histamine. In less severe asthma drug reduces gistaminindutsirovannuyu bronchoconstriction . Zodak has no antiserotoninovogo and protivoholinergicheskogo action. Receiving therapeutic doses does not cause the formation of the effects of sedation. Upon receiving the 10 mg dose in 50% of patients develops antiallergic action after 20 minutes and lasts for hours. In exchange treatment tolerance to the drug were observed. Zodak available in tablet form, in the form of drops, a solution, a syrup.

Indications:

Zodak prescribed for seasonal, year-round allergic rhinitis and conjunctivitis genesis. The drug is effective in atopic asthma, angioedema , Skin ulcers, allergic dermatitis, hay fever , Chronic idiopathic urticaria.

Contraindications:

Zodak not prescribe intolerance hydroxyzine, cetirizine, breastfeeding, pregnancy. In chronic renal pathology systems, the elderly and pediatric use with caution.

Side effect:

Use of the drug can be accompanied Zodak dyspeptic disorders, allergic reactions, headaches, dry mouth.

Overdose:

Higher doses intensifies the side effects, there is increased irritability, anxiety, disorders stool, increased drowsiness, dry mouth, urinary retention. Timely gastric lavage, symptomatic medications, there is no antidote. Hemodialysis does not bring relief.

Mode of application:

Zodak Inside, drinking plenty of fluids. Drops are dissolved in water. The drug is taken 10 1 mg once a day or divided into 2 doses of 5 mg. When kidney disease receiving cetirizine systems start with 5 mg per day. In some cases Zodak taken every other day for 5 mg.

Special instructions:

Higher doses of the drug is accompanied by a decrease in the rate of psychomotor reactions. Recommended dosage of the drug did not potentiate the effect of alcoholic beverages, but in the period of anti-allergic therapy to a complete rejection of ethanol. During treatment must be careful in the management of complex mechanisms, when driving.

Drug Interactions:

Zodak reveals no pharmacologically significant interactions when taken with glipizide . azithromycin . ketoconazole , Diazepam, erythromycin , Cimetidine, pseudoephedrine. When co-administered with theophylline   at a dosage of 400 mg per day of a decline total clearance   Zodak preparation, and the action of theophylline is not changed. Myelotoxic drugs increase haematotoxicity   medicament.