Description overdue on 02/17/2013

Bronchodilator.   Active ingredient - theophylline . The mechanism of action is based on the blocking of purine (adenosine) receptors increase cAMP accumulation in the tissues, on the inhibition of phosphodiesterase, on reducing the contractility of the smooth muscle fibers decrease in revenues through the channels of the cell membranes of calcium ions. The main component of the preparation is purine derivative . Neofillin increases renal blood flow , Has a relaxing effect on the smooth muscle tissue, located in blood vessels (mainly affects the blood vessels of the kidneys, brain, and skin), the bronchi. The drug has a moderate diuretic effect, it has a peripheral vasodilating effects.

Theophylline stimulates contraction of diaphragmatic muscles, improves intercostal and respiratory muscles, increases mucociliary clearance , Stimulates the respiratory center, hinders the process of the release of allergic mediators, stabilizes the membrane of fat cells. Due to the normalization of the function of the respiratory medicament reduces carbon dioxide and improves oxygenation of the blood, stimulates the respiratory center . At hypokalemia   drug enhances pulmonary ventilation . In the cardiovascular system Neofillin increases the need for oxygen in the myocardial tissue, has a stimulating effect on the coronary blood flow, increases the heart rate and force of contraction, stimulates the heart, reduces the tone of blood vessels.

The drug is able to reduce the pressure in the "small" circle of blood and pulmonary vascular resistance. Moderate severity diuretic effect   achieved by increasing renal blood flow. The drug is able to expand the lumen bile duct . Effect on blood to normalize microcirculation Positively influences rheological properties of blood Increases red blood cell resistance to deformation, reduces the rate of platelet aggregation (alpha inhibits prostaglandin and platelet activating factor). Neofillin available in tablet dosage form, in the form of suppositories, capsules and long-acting.

Indications:

Drug Usage Neofillin recommends prescribers at broncho-obstructive syndrome   various origins: emphysema COPD, chronic obstructive bronchitis, bronchial asthma (in the complex therapy in the treatment of patients with bronchial asthma physical exertion). The drug is prescribed for sleep apnea, "pulmonary" heart, pulmonary hypertension In the complex therapy of edematous syndrome of renal origin.

Contraindications:

Use of the drug is contraindicated in Neofillin epilepsy in severe hypotension or hypertension, ulcer disease of the digestive tract, intolerance theophylline hypersensitivity to theobromine, pentoxifylline, caffeine, when giperatsidnom gastritis, severe course tachyarrhythmia , Retinal hemorrhage, hemorrhagic stroke Children under the age of three.

With increased convulsive readiness, with severe coronary insufficiency   (angina pectoris, acute myocardial infarction), with frequent ventricular arrhythmia GOKMP, total vascular atherosclerosis, severe liver disease and kidney failure, bleeding in the digestive tract, chronic heart failure, uncontrolled flow hypothyroidism   (risk of accumulation), and peptic ulcer disease of the digestive tract, gastroesophageal reflux disease, prolonged hyperthermia, hyperthyroidism, pregnancy, during prostatic hypertrophy , Breastfeeding, children and the elderly Neofillin experts appointed after consultation with caution. Rectal dosage forms of the drug are contraindicated in diseases of the colon and diarrhea.

Side effect:

Nervous system:   limb tremor, dizziness, agitation, irritability, anxiety . insomnia , headache. Cardiovascular system:   increased frequency of angina attacks, drop in blood pressure, arrhythmia, tachycardia , Palpitations, kardialgiya. The digestive tract:   violation of appetite, heartburn . vomiting . stomachalgia , Worsening peptic ulcer . gastroesophageal reflux disease . nausea , Diarrheal syndrome. Perhaps the development of allergic reactions during treatment in the form of fever, itching and skin rashes. Rarely observed albuminuria . tachypnea , Chest pain, hypoglycemia , Hematuria, feeling the tides to the facial skin, increased sweating, increased diuresis. By reducing the dosage of theophylline severity of side effects is reduced.

Overdose:

Manifested flushing of the skin, nausea, stomachalgia , Tachypnea, vomiting, decreased appetite, motor agitation, anxiety, insomnia and the development of ventricular arrhythmias, seizures, tremors, photophobia . In severe poisoning develops metabolic acidosis , Epileptic seizures, drop in blood pressure, kidney failure with myoglobinuria , Confusion, necrosis of skeletal muscles, hypokalemia, hyperglycemia. Requires removal of medication, intestinal lavage solutions of electrolytes ipolietilenglikolya appointment of laxatives, activated charcoal and enterosorbents. Vomiting prescribe ondansetron, metoclopramide. Peritoneal dialysis is not proven effective, it recommended holding hemosorption , Forced diuresis, plasma sorption hemodialysis. With the development of seizures carried out oxygen therapy and provide an open airway. It is recommended that intravenous administration of diazepam.

Mode of application:

Neofillin tablets and capsules are taken orally, washed down with the required amount of water .  The average dose for adults is 300 mg twice a day .  In some cases, the amount of the drug is increased to 900 mg per day .  Patients weighing more than 60 kg are given an initial dose - 200 mg .  For patients weighing less than 60 mg initial dose is 100 mg .  Treatment with Neofillin administered with minimum dose, and then gradually increased to achieve the desired therapeutic effect .  In the case of intolerance to reduce the amount of medication .  The dose of theophylline selected individually depending on the weight, age and the nature of the underlying disease .  In the case of the need for treatment with high doses of the drug Neofillin necessarily dynamic monitoring of the blood levels of theophylline .  When registering a low concentration of the basic substance daily dosage is increased by 25% every 3 days .  When the stabilization of the patient monitoring indicators carried out every 6-12 months .  Elderly patients with severe liver disease, heart in   viral infection   it is recommended to reduce the daily dosage. The action of the drug is shown in full in 3-4 days after the start of theophylline.

Special instructions:

Therapy prolonged dosage forms of the drug Neofillin requires mandatory and routine control measure of the concentration of the active substance in the blood. We recommend caution in the use of foods and beverages containing caffeine . With good control of bronchial asthma and the absence of side effects, the dose change every 6-12 months. Neofillin retard tablets are not used for the relief of emergency conditions.

Drug Interactions:

Application enterosorbents , Antidiarrheal drugs and activated carbon leads to decreased absorption of the active drug substance Neofillin. The drug increases the risk of side effects during therapy glucocorticosteroids , Drugs for general anesthesia (developing ventricular arrhythmias), drugs that stimulate the central nervous system (increased neurotoxicity) and ISS (developing hypernatremia ). Moratsizin, estrogensoderzhaschie oral contraceptives, isoniazid, phenobarbital, aminoglutethimide, sulfinpyrazone, carbamazepine, phenytoin, rifampin are inducers of microsomal oxidation and increase the rate of clearance of theophylline, which requires an increase in the dosage of the drug Neofillin.

Inhibitors of cytochrome P450 (antibiotics macrolide, fluoroquinolone, cimetidine, allopurinol, linkomitsin ), Recombinant interferon alfa, disulfiram, isoprenaline, Methotrexate , Enoxacin, propafenone, ticlopidine, thiabendazole, mexiletine, verapamil Neofillina require dose reduction, enhancing the effect of the drug. The drug is not used in conjunction with other xanthine derivatives, fully compatible with antispasmodic drugs . Theophylline enhances the effect of diuretics, beta-agonists by increasing glomerular filtration rate ; the opposite effect is observed for the simultaneous treatment of beta-blockers and lithium preparations. Neofillin cautiously prescribed for admission anticoagulants .