Description overdue on 12.10.2011

Alkaloid . Mr. holinoblokator . Obtained from plants of the nightshade family. Under the influence of Atropine decreases the secretion of lacrimal, sweat, stomach, salivary, bronchial glands, decreased muscle tone of the internal organs (bladder, gall bladder, bronchi, bile ducts, urinary tract, pancreas), the tone of the sphincter, improves AV-conduction occurs   tachycardia . Atropine increases in intraocular pressure. Under his action violated the outflow of intraocular fluid, pupils dilate, and manifests cycloplegia . The therapeutic dosage of the drug stimulates the central nervous system. Toxic doses cause agitation . excitation . coma . hallucinations . Produced in tablet form, the form of injections and infusions for ingestion, eye ointments and eye drops.

Indications:

Ulcerative lesions of the gastrointestinal tract, cholelithiasis . pilorospazm . cholecystitis . hyperptyalism   (at stomalogicheskih interventions poisoning with salts of heavy metal, Parkinsonism ), Acute pancreatitis, irritable bowel syndrome, bronchial asthma , Biliary colic, bronchitis   with increased mucus, intestinal colic, laryngism , Bronchospasm, bradycardia , Renal colic, AV-blockade. Atropine is prescribed for anticholinesterase poisoning, m-holinostimuliruyuschimi PM.

Contraindications:

Atropine is not prescribed for glaucoma. Precautions: atrial fibrillation, coronary artery disease, hypertension, mitral stenosis, acute bleeding , Fever, thyrotoxicosis , Hiatal hernia,   reflux esophagitis , Pyloric stenosis, liver failure, esophageal achalasia , Intestinal, dry mouth, chronic lung disease, myasthenia , Renal failure, prostatic hypertrophy, paralytic ileus, urinary retention, ulcerative colitis . preeclampsia , Down syndrome, cerebral palsy .

Side effect:

Expressed mydriasis, xerostomia, atony of urinary bladder, tachycardia . constipation . photophobia , Urinary retention, headache, paralysis of accommodation, intestinal, violation of tactile sensitivity, vertigo.

Mode of application:

Atropine is taken orally three times a day: in the ulcerative lesions of the gastrointestinal tract of O 25-1 mg. The on / in / m or s / c administration: O 2p 25-1 mg per day. With bradycardia   1 g of atropine administered intravenously, if necessary repeat injection after 5 minutes. With anticholinesterase poisoning, m-holinostimuliruyuschimi PM   administered intravenously 0, 1% solution in doses of 1, 4 ml. Preferably combined with Reaktivatory cholinesterase. Premedication 0, 4-0, 6 mg intramuscularly one hour before anesthesia.

Overdose:

A slight excess of the specified dosage leads to dry mouth, accommodation disturbances, dilated pupils, tachycardia, intestinal, difficulty urinating, dizziness. When poisoning is marked dryness of the skin, mucous membranes, increased intraocular pressure, dilate pupils, delayed urination, fever, appear hallucinations , Tachycardia, loss of consciousness, pronounced psychomotor agitation, disorientation, convulsions, drop in blood pressure, coma. An antidote is a neostigmine methylsulfate , It is administered subcutaneously at a dose of 1 ml of 0 05% solution. In the absence of neostigmine is administered physostigmine . In convulsions appointed barbiturates   (geksenal w / w). When injected intramuscularly psychomotor agitation 2 ml chlorpromazine .
When urinary retention is a catheterization. When hyperthermia - wet wraps, ice groin forehead. In severe intoxication spend alkalization of blood, forced diuresis . It is recommended to introduce glucose and ascorbic acid.

Special instructions:

It is recommended between doses of antacid drugs and atropine to keep an interval of at least 1 hour. In a dramatic admission of the drug in the body is marked syndrome "cancel". Atropine reduces reaction rate.

Drug Interactions:

Promethazine   and diphenhydramine   enhance the effectiveness of action of the drug. Simultaneous reception of nitrates increases intracranial pressure. Guanethidine   reduces giposekretorny effektatropina. Procainamide   It can enhance the anticholinergic effect of the drug. Antacids reduce the absorption from the gastrointestinal tract Atropine. Atropine is capable of delaying absorption mexiletine It reduces the level of levodopa   in blood.