Description overdue on 08/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Domperidone, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The composition of one tablet contains the active component domperidone   - 10 mg + additional substances ( microcellulose, colloidal silicon dioxide, macrogol, polyvinyl alcohol, talc, starch, magnesium stearate, polyethylene glycol, titanium dioxide ).

Product form

The drug release in the form of white (or with a yellowish tinge) tablets round convex shape, film coated. If you break the tablet in half, you can see white or yellow slice. The contour packs of 10 pieces in cardboard packs of 10, 20, 30, 40 or 50 pieces.

Pharmacological action

Antiemetic   means.

Pharmacodynamics and pharmacokinetics

The active substance is central dopamine receptor antagonist   (D2). Inhibits peristalsis   and locomotor activity ZHTK Thus calms hiccups . nausea   and vomiting . Its action is to close metoclopramide However, unlike the latter, domperidone   It does not cause disturbances of coordination and tremor . This is due to the fact that the drug does not overcome blood-brain barrier .

Indications

Vomiting and nausea are caused by:

• holding radiation therapy ;
• Taking certain drugs ( Morphine, levodopa Apomorphine, bromocriptine );
• organic and functional disorders;
• different infections .

Also serves as an indication for use

• post-operative intestinal atony ;
• hiccough ;
• radiopaque study   gastrointestinal tract;
• flatulence . abdominal distention . heartburn . belching .

Contraindications

Contraindication to receiving the drug is

• ileus ;
• lactation;
• enterobrosia   or stomach;
• gastric ulcer   and bleeding   stomach;
• allergy For any component of the means.

The medicine is not administered to children under the age of 5 years and weighing up to 20 kg.

Be particularly careful when you use in patients with liver and kidneys.

Side effects

FEATURES:

• upset stomach or intestines, spasms ;
• skin rashes, hives Allergies;
• galactorrhea, amenorrhea, gynecomastia ;
• extrapyramidal disorder .

Domperidone, instructions for use (method and dosage)

The drug is taken half an hour before a meal without chewing or gnawing the tablet.

According to the instructions on the use of domperidone, the maximum daily dose is 80 mg.

In the acute phase or severe nausea and vomiting, 20 mg administered 3 times per day. The last dose taken just before bedtime.

For chronic symptoms take 10 mg 3 to 4 times per day.

Daily dosage adjustment is required for patients with diseases of the liver and kidneys. In this case, the tablets did not take more than 2 times per day.

Overdose

Symptoms of overdose is drowsiness , Various   extrapyramidal disorder . disorientation .

If you have symptoms of overdose should take chelators   and wash the stomach. Recommended application Mr. holinoblokatorov . antihistamines .

Cooperation

Antacids   and Mr. holinoblokatory   neutralize the effect of the drug on the body.

Also, the therapeutic effect of reducing medication Cimetidine   and   NaHCO .

The plasma concentration and the side effects are increased when combined with antifungal agents   series azole . HIV protease inhibitors , Antidepressant Nefazodone . Ketoconazole . antibiotics   from the group macrolide   (any inhibitors of the enzyme CYP3A4 ).

Acceptable combination with medication Paracetamol . neuroleptics . Digoxin . Levodopa . Bromocriptine .

Terms of sale

In order to buy the drug requires a prescription.

Storage conditions

Keep away from children. In the dark, cool place.

Shelf life

3 years.

Analogs Domperidone

Analogues of the drug are: Teva-Domperidone, Damelium, Domperidone hexane Domstal, Motilak, Motinorm, Passazhiks, Dometius, Motizhekt, Motilium, Motonium .

Reviews of domperidone

Effectively relieves spasms and pain in the stomach, removes nausea and vomiting. Reviews for Domperidone and Domperidone -Teva good. Side effects are rare, usually only in the first days of admission.

Price domperidone, where to buy

Domperidone price is about $ 100 for 30 tablets.