Description overdue on 09/22/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use: what is prescribed capsules and syrup Enterofuril
• Contraindications
• Side effects
• Instructions for use Enterofuril
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Synonyms
• Enterofuril children
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One capsule contains 100 Enterofuril or 200 mg Nifuroxazide   as the active substance and several auxiliary components:

• corn starch (Amylum maidis);
• sucrose (Saccharose);
• Microcrystalline cellulose (Cellulose microcrystallic);
• Magnesium Stearate (Magnesium stearate).

The structure 5 includes Enterofuril ml suspension of 200 mg Nifuroxazide , and:

• sucrose (Saccharose);
• Sodium hydroxide (Natrii hydroxidum);
• methyl parahydroxybenzoate (Metylparahydroksibenzoat);
• Ethanol (Ethanol);
• carbomer (Carbomerum);
• citric acid (Citric acid);
• Water (Aqua);
• banana flavor.

Product form

Enterofuril has three forms of production:

• gelatin capsules №0;
• gelatin capsules №2;
• suspension.

Capsules №2   hard, yellow, opaque, filled yellow powder (insertions, which are small particles compacted mass) containing 100 mg of active substance.

Capsules №2 packaged in blisters 10 pcs. In a cardboard blister pack 3.

The capsules №0   active matter content - 200 mg. The capsules are packaged in blisters №0 8 pieces. In one carton can be 1 or 2 of the blister.

A suspension for oral   It has the form of a thick yellow liquid with a characteristic smell of banana and is available in 90 ml dark glass bottles of 100 ml (included with each bottle of the drug is a measuring spoon).

Pharmacological action

The active substance belongs to the group Enterofuril Antimicrobial drugs Used to treat infectious intestinal diseases And characterized by the ability to provide antimicrobial action.

Pharmacodynamics and pharmacokinetics

Efficiency Enterofuril activity due to being a part of Nifuroxazide . The substance acts locally, without penetrating into different cloth   and bodies So the drug has only Antidiarrheal effect , Any systemic effects after administration are absent.

Antimicrobial effect   Enterofuril dose dependent: thus, its low and medium doses provide a bacteriostatic effect against pathogens , High - bactericidal .

Mechanism bacteriostatic action   the drug is associated with the suppression of dehydrogenase enzyme activity And this, in turn, violates the synthesis of vital cell microorganism compounds.

Bactericidal   mechanism of action is determined by the ability of high doses of Nifuroxazide   have a devastating effect on bacterial cell membrane . Violation of integrity cytoplasmic cell membrane   provoking death microorganism .

Nifuroxazide   inhibits the production of pathogens enterotoxins That can reduce the severity of irritation intestinal epithelial cells   ( enterocytes ) And decrease the activity of fluid secretion in the lumen and salts guts .

Clinical studies have shown that Enterofuril has the ability to activate the protective function immune system . This effect is due to the fact that Nifuroxazide   stimulates phagocytosis .

Thus Enterofuril therapeutic doses has no adverse effect on the normal intestinal microflora Not provoke the emergence of resistant to the action of microbial forms, as well as the development of cross-resistance pathogens   other antibacterial agents .

Nifuroxazide   active against Gram-positive   (Gram (+)) and Gram   (Gram (-)) Microorganisms Which include bacteria   genus Staphylococcus spp. (Staphylococci), Streptococcus spp. (streptococci), Haemophilus influenzae (Pfeiffer stick), Salmonella spp. (salmonella), Shigella spp. (Shigella), Enterobacter spp. (Enterobacter), Klebsiella spp. (Klebsiella), Escherichia coli (E. coli) and Proteus spp. (Proteus).

At intestinal diseases of viral origin   Enterofuril reduces the risk of b akterialnoy superinfection .

After ingestion of the drug is practically not absorbed from GI About 99% of it remains in gastrointestinal tract .

Nifuroxazide   and its products metabolization   excreted with the content bowel . The elimination rate is dependent on the dose of the drug and characteristics of motor GI   particular patient.

Indications for use: what is prescribed capsules and syrup Enterofuril

According to the summary, indications for use Enterofuril are:

• acute   and chronic diarrhea Provoked pathogens Susceptible to the drug (except for those cases when the patient has symptoms helminthic invasion );
• chronic diarrhea   patients inflammation of the mucous membrane of the large intestine ;
• diarrhea It is a consequence of uncontrolled admission of certain Antimicrobial drugs   (eg, antibiotics );
• diarrhea of ​​unknown origin   (in both acute and chronic form).

Contraindications

The drug is contraindicated in persons with hypersensitivity to Nifuroxazide   and members of the drug excipients, as well as other drugs, are derivatives nitrofuran series .

In addition, in the form of a suspension Enterofuril not indicated for children younger than 2 years old. The tablets may only be used when the child reaches 6 years of age.

Side effects

Like any other drug, Enterofuril can cause side effects, which are often expressed as:

• abdominal pain;
• nausea;
• amplification diarrhea.

These symptoms are temporary in nature, do not require treatment, dose review and withdrawal of the drug.

In some cases, a patient may respond to receiving Enterofuril allergic reactions . If the use of the drug appears rash . angioedema . hives   or develops anaphylactic shock Treatment they immediately stopped.

Instructions for use Enterofuril

The suspension Enterofuril: instructions for use

The suspension is intended for oral administration. Adult patients taking the medication prescribed to 20 ml per day. Said daily dose is recommended to divide into 4 receptions. Before use, the vial should be shaken Enterofurilom.

Capsules Enterofuril: instructions for use

Enterofuril daily dose for adults - 800 mg. Share it recommended on 4 receptions. That is, drug taking one capsule of 200 mg or two capsules of 100 mg at one time.

Enterofuril: like taking pills and syrup for children

Children dosage Enterofuril - 600-800 mg a day - that is, two 100 mg capsules or one capsule of 200 mg three or four times per day. The tablets show children over 6 years of age.

The suspension is allowed to be used in children older than 2 years of age. The daily dose for children - 15 ml. Multiplicity of reception - 3.

How many days of taking the drug, determined by a physician, but also for children and adults the duration of treatment should not exceed 7 days.

One of the most common issues that arise in most patients, this is the question of how to make - before or after meals. The instructions to Enterofurilu indicated that the drug can be taken without being tied to meal times.

Overdose

Currently Enterofurilom overdose are unknown. This is because the drug is not absorbed from the GI   and misses in systemic circulation .

If you exceed the recommended dose and the onset of symptoms intoxication   the body, act as in case of poisoning: do gastric lavage   and assigning the patient symptomatic treatment.

Cooperation

Due to lack of systemic absorption   the probability of interaction Nifuroxazide   with other drugs is unlikely. However, it should not be administered in combination with alcohol-containing drugs, medications, provoking precipitates a reaction As well as drugs that provide a depressing effect on CNS .

Terms of sale

Enterofuril available without prescription.

Storage conditions

Special storage requirements Enterofuril in the form of capsules available. The drug is in the form of a suspension should be stored in a dry place, protected from sunlight. The optimal temperature - 15-30 ° C. Do not freeze the suspension.

Shelf life

The capsules are allowed to use for 5 years after the date of issue.

The suspension retains its pharmacological properties for 3 years after the date of issue. Shelf life after opening the bottle - no more than 7 days.

Analogs Enterofuril

Analogues are French drug Enterofuril Intetriks   and produced in Pakistan by Pakistan Herbion Privet Limited drug Entoban .

Price Enterofuril analogues varies depending on the particular pharmacy. So, Intetriks   Ukraine can buy an average of 94 USD. Thus in some pharmacies sell it for USD 74-76, and in some price for it reaches 129 UAH.

Entoban   - Cheaper counterpart Enterofuril. Its average price for Ukrainian market framatsevticheskom - 27 UAH.

Cons of both drugs is that they have age limits, and do not apply to young children.

Intetriks   It has no "children's" Method of production: it is produced only in the form of capsules and is contraindicated in children. Entoban has two release forms - syrup and capsules. The capsules are designed to treat only adults, contraindication to syrup is under the age of 4 years, while Enterofuril allowed for children from 2 years old.

Also Enterofuril analogues are: Furazolidone . Enterol .

Enterofuril or furazolidone - which is better?

Furazolidone   - this antimicrobial nitrofuran series Which have activity against Gram (-) bacteria   and - to some degree - in respect of Gram (+) bacteria   and fungi of the genus Candida .

Its action is aimed at the suppression of life Microorganisms Blocking occurring in Microbial cells biochemical processes   and distortion of the structure Microbial cells .

Insensitive to drugs are anaerobes   and organisms Which are pathogens of purulent infections .

Unlike Enterofuril Furazolidone   characterized by the ability to be absorbed from the GI   and penetrate blood plasma . Metabolization   It contained therein as an active ingredient Nifuroxazide   It occurs liver .

Excreted same substance and metabolites   across kidneys   in the urine, making inappropriate use of the drug to patients with diseases liver   and / or kidney .

What does help furazolidone tablets? Indications for drugs are paratyphoid . dysentery . food poisoning   and infection . Also, it may be used in a treatment solution infected burn wounds .

Admission furazolidon provokes quite a number of side effects, including stomach ache . nausea .   vomiting . allergic reactions . Young children and infants (the drug is permitted to apply from 1 month), on the background of treatment can be observed:

• anemia   (anemia);
• an increase in blood levels methemoglobin ;
• breathlessness ;
• coughing ;
• neurotoxic reactions .

If you consider the option of selecting a treatment for the child, for the totality of contraindications, the number of possible adverse reactions and the hazards of the internal organs (eg, liver   and kidneys ), In comparison with Enterofuril Furazolidon   It is safer.

Enterol or Enterofuril - which is better?

Enterol   and Enterofuril - two different drugs that have certain common effects. Thus, a Enterofuril antiseptic   broad-spectrum, has a devastating effect on pathogens , Located in intestinal lumen .

For this reason Enterofuril widely used as a treatment for diarrhea infectious nature of origin . Breaking livelihoods and causing death Microbial cells It effectively removes the cause of the diarrhea .

Enterol   It has a devastating effect on a narrower range of Microorganisms Provoking development diarrhea . Besides drug normalizes intestinal microflora And increases survival lacto - And bifidobacteria .

For this reason, serious   infectious diarrhea Which is accompanied by a rise in temperature, to eliminate the cause of the pathological state recommended the appointment Enterofuril.

At dysbacteriosis   and diarrhea Flowing without fever, considered a more rational use to treat Enterol That relieves symptoms and pathological condition and normalizes microflora in the intestinal lumen . Enterofuril same in this situation is absolutely useless.

For prevention dysbiosis Which is a consequence of receiving antibiotics , Should also take Enterol As Enterofuril only reinforce the action and effect antibacterial medicament .

Synonyms Enterofuril

Synonyms (or generic) Enterofuril are the following drugs:

• Ersefuril ;
• Diastat ;
• Lekor ;
• Nifurozid ;
• Nifuroxazide ;
• Stopdiar .

Many people are interested in the issues " Ersefuril   or Enterofuril - which is better? "," Stopdiar   or Enterofuril - which is better? ", "What is the difference   Ersefuril   and Enterofuril? ".

In answering this question, doctors and pharmacists say that all of these funds - Stopdiar . Ersefuril . Diastat   etc. - Are absolutely identical in its action, the indications and contraindications. The only difference is that they produce different pharmaceutical companies.

Enterofuril children

Instructions on Enterofuril Children warns that the drug has age restrictions. For Enterofuil capsules prohibited use in children under 6 years of age, in the form of syrup - up to 2 years.

In cases where a child is accompanied by diarrhea   vomiting Before the appointment should be deleted diarrhea Which is a consequence of   helminthic invasion   or viral infection   (for example, hepatitis ).

Since the product is used for the treatment of bacterial diarrhea Then it is allowed to take vomiting   in children, as well as diarrhea Accompanied by an increase in temperature.

Quite often young patients taking both prescribed and Enterofuril Smectite . The drug has a different effect: the action is aimed at Enterofuril destruction of intestinal infection , Smecta also envelops gut wall   and stomach Thereby exerting a beneficial effect on barrier function of the mucosa of the digestive system   and increasing the resistance contained in GI   mucus to stimuli.

Many doctors call preparation " intestinal antibiotic "And, therefore, mothers are often afraid to give it to young children. They are also interested in the question "Enterofuril - it antibiotic   or not? "

The active ingredient of the drug - a derivative nitrofuran . Despite the fact that all the preparations nitrofuran series   have bacteriostatic   and bactericidal action . antibiotics   they are not.

Antibiotic   - The substance is a natural or semi-synthetic origin that have the ability to inhibit the growth and reproduction bacterial cells . Nifuroxazide as is a fully synthetic drug.

The site of Dr. Komarovsky the questions of what and how safe Enterofuril its use in pediatrics. The article states that the active ingredient of the drug - Nifuroxazide - A recognized means of unproven efficacy.

Safety of nifuroxazide to treat children

Initially, Nifuroxazide (entitled Ertsefuril And later in the form of generic drugs) appeared in France about 50 years ago. The drug is used as a means of diarrhea   for treatment of children older than one month. The indication for its purpose was acute diarrhea Induced expectation bacterial infection .

However, 30 years later the scope of the drug has changed significantly. Since the mid 90-ies of the last century, 100 mg capsules have been left for the treatment of children over 6 years old, and 200 mg capsule administered to adult patients only.

Suspension for oral administration is recommended for use in children from months of age. Since 2000, the year it began to prescribe the dosage form as a supplement to rehydration therapy .

In 2003 it was revised benefit / risk ratio Nifuroxazide . As a result of this revaluation suspension Enterofuril banned for children administered to children who are under 2 years old.

Enterofuril and alcohol

During treatment Enterofurilom consumption of alcohol is prohibited. The drug violates the splitting of alcohol, which is accompanied by the accumulation in the body acetaldehyde   and development symptoms of poisoning Which are expressed in the form:

• raising the temperature;
• redness of the skin;
• vomiting;
• the appearance of the noise in my head;
• difficulty breathing;
• Gain diarrhea;
• heart palpitations;
• the emergence of unjustified fear.

Enterofuril during pregnancy

To date, reliable data on the teratogenicity and embryotoxicity Enterofuril feto- not. Therefore, to avoid the possible adverse effects to the fetus, the drug is not recommended during pregnancy.

Lactating women are allowed to use Enterofuril only provided short-term treatment.

Reviews Enterofurile

Reviews Enterofurile forums quite controversial. The undoubted advantage of the drug most people believe that it:

• member of the group antimicrobials , but not antibiotics ;
• It is active against nearly all bacteria It is cause infectious intestinal diseases   (in particular, it is active against Proteus Against whom the majority are powerless antibiotics );
• no effect on   saprophytic intestinal flora   and not provoke digestive disorders   (so quickly normalized balance gut   and the faster the healing intestinal mucosa );
• increases the effectiveness of   immune system Stimulating its ability to resist Infections   and increasing the concentration of antibodies .

Another valuable property of the drug is that pathogens   not developed resistance to it.

Enterofuril not absorbed from the GI It does not affect the function of various organs and systems, and the site of action is extremely   intestines . For this reason, means belongs to the category of safe medicines that are allowed to prescribe, even little children, and - in some cases by the physician - to pregnant women.

   

At At vomiting   pathogenic bacteria .

Microorganisms  

bacteria   bacteria .

systemic circulation