Description overdue on 06/06/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Ganaton
• Contraindications
• Side effects
• Instructions for use Ganaton
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet Ganaton contains as active substance hydrochloride itopride   in an amount of 50 mg. As auxiliary substances are contained: corn starch   - 15 mg, lactose   - 34,975 mg, carmellose   - 20 mg, silicic acid, anhydrous   - 4 mg magnesium stearate   - 1 mg, Valium   - 4.4 mg titanium dioxide   - 0.2 mg Macrogol 6000   - 0.4 mg, carnauba wax   - 0.025 mg.

Product form

The drug is available in tablets, coated light-colored, rounded, with a strip on one edge and the inscription " HC 803 ". Seven, ten or fourteen of such tablets in the blister. Five, four, three, two or one a blister in a carton box.

Pharmacological action

The drug stimulates the tone and motility of the stomach and intestine action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Mechanism of action. Hydrochloride itopride   activates the motility of the stomach due to the suppression D2-dopamine   receptors acetylcholinesterase .   Itopride   suppresses destruction acetylcholine   and enhances its release.

Hydrochloride itopride   also provides antiemetic   inhibiting effect D2-receptors , Localized in trigger field and causes a dose-dependent inhibition of emesis induced Apomorphine .

The drug activates the propulsive motility of the stomach and accelerates the transit of food through the stomach and its emptying. It does not affect the concentration gastrin   in serum.

Pharmacokinetics

Absorption. The drug is rapidly and almost completely absorbed from the stomach and intestines. Bioavailability is 60% - this is due to transformation of molecules at the first passage through the liver. Ingestion would not affect the bioavailability.

After ingestion of 50 mg hydrochloride itopride   the maximum concentration is reached after half an hour. At the following reception of the drug amount from 50 to 200 mg three times a day during the week of the pharmacokinetics of the drug and its derivatives did not change, and the effect of the accumulation was observed.

Itopride bound to plasma proteins ( albumin To a lesser extent with alpha-1-acid glycoprotein ) 96%. Actively spreads through the tissues and is detected in high concentrations in   small intestine, kidney, adrenal, liver   and stomach . Penetrates dorsal   and brain   in small quantities. Is able to penetrate into breast milk.

Metabolism. The drug is undergoing active transformation in the liver. There are three metabolites, only one of them exhibits a weak activity, are not of great importance.

Itopride decomposes under the influence flavinzavisimoy monooxygenase , Its concentration and efficacy in humans depends on a congenital polymorphism. Patients with Trimethylaminuria   half life itopride   increases.

Withdrawal. The drug and its metabolites are excreted in urine. The terminal half-life itopride is 6 hours.

Indications Ganaton

The drug is used to treat functional dyspepsia   non-ulcer character ( chronic gastritis ). Use of the drug is justified for relief:

• sensation of satiation;
• bloating;
• discomfort and pain in the upper abdomen;
• anorexia;
• nausea ;
• heartburn;
• vomiting .

Contraindications

• Gastric or intestinal bleeding . mechanical obstruction   or perforation   GIT.
• Breastfeeding (lactation).
• Pregnancy.
• Children under the age of 16 years.
• Sensitization   to itopride   or other component of the preparation.

Side effects

During clinical studies (1-3 phase) itopride   well tolerated, serious adverse events were reported. The bulk of the complaints of adverse reactions were: headache, diarrhea . abdominal pain .

Deviation blood parameters observed during the study: leukopenia, an increase in prolactin levels .

Most often, this medicine may cause the following side effects:

• by the immune system - anaphylactic shock ;
• by the endocrine glands - gynecomastia . an increase in prolactin levels ;
• from the peripheral and central nervous system - headache, dizziness, tremors;
• on the part of the digestive system - diarrhea , Abdominal pain, constipation , Salivation, nausea;
• from the hepatobiliary system - jaundice ;
• For the skin - rash, redness, itching;
• violations of the clinical tests - increase in ALT, AST, alkaline phosphatase, GGT, bilirubin .

Instructions for use Ganaton

Instructions for use Ganaton recommends taking the medicine into 50 mg (1 tablet) three times a day before meals. The recommended daily dose - 3 tablets. This dose may be reduced based on patient age.

Overdose

No cases of overdose No replies. If she did come, it is necessary to make gastric lavage   and start symptomatic treatment .

Cooperation

At simultaneous reception with Ganaton diazepam . warfarin . diclofenac , Ticlopidine hydrochloride, nifedipine   and Nicardipine hydrochloride   violations of interaction itopride   with blood proteins is not observed.

Itopride   enhances gastric motility, thus it affects the absorption of other substances with simultaneously applied Ganaton. Particular caution should be taken when using drugs with a low therapeutic index, prolonged release and an enteric coating.

Anticholinergic drugs   weaken the effect   itopride .

Terms of sale

The preparation is available strictly on prescription.

Storage conditions

Keep out of the reach of children.

Shelf life

Three years.

Cautions

Itopride hydrochloride   must be used with caution in the elderly. It is necessary to monitor the state of health of these patients, as they are more common kidney damage, liver and other diseases or concurrent therapy other drugs.

When deciding on a driving need to consider the possibility of dizziness.

Analogs Ganaton

The most famous counterparts Ganaton: Zirids   (Slovakia) Itomed   (Czech Republic), Primer   (India / UK). Form release all of these analogues - tablets. Price analogues Ganaton usually fluctuates in the same price range or below it.

Babies

Safe use in children under the age of sixteen years, has not been proved.

During pregnancy and lactation

Safety of use hydrochloride itopride   during pregnancy was established. Therefore, do not carry a drug therapy in this period, except in cases prescribed by the doctor if necessary.

During the period of breastfeeding is necessary to refuse to accept Ganaton.

Reviews Ganaton

At various forums can be read quite mixed reviews about Ganaton and experience of taking this drug. In general, the vast majority of reports confirms the effectiveness of the drug, but not rare information on the occurrence of side effects.

Is it better or Ganaton Motilium?

In independent studies in patients with dyspeptic symptoms in the last month Ganaton showed greater efficacy in relieving symptoms than pathological Motilium .

Price Ganaton

In Russia, the price Ganaton (40 pieces) varies from 440 to 520 rubles, Ukraine, such a drug can be bought on average for 240 hryvnia.