Description overdue on 04/06/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Gastal
• Contraindications
• Side effects
• Instructions for use Gastal
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Amount per lozenge:

• Active ingredients: Gel aluminum hydroxide - magnesium carbonate   - 450 mg magnesium hydroxide   - 300 mg;
• Excipients: lactose monohydrate   - 30 mg, sorbitol   - 50 mg, mannitol - 120 mg corn starch - 75 8 mg Sodium cyclamate   - 7 mg sodium saccharinate   - 0 2 mg talc   - 28 mg, magnesium stearate   - 6 mg peppermint flavor   - 3 mg.

The composition of mint or cherry lozenges:

• Active ingredients: Gel aluminum hydroxide - magnesium carbonate   - 450 mg magnesium hydroxide   - 300 mg;
• Excipients: lactose monohydrate   -112 Mg;   pregelatinized starch   -32 Mg; mannitol   -112 Mg; Croscarmellose sodium   -50 Mg; colloidal silica   -2 Mg; magnesium stearate   -6 Mg; Aspartame   -2 Mg; mint flavor   (for the mint tablets) - 6 mg; cherry flavor   (for tablets cherry) - 4 mg.

Product form

Tablets intended for resorption (tasteless, mint or cherry) white or close to white color, rounded, smooth.

Conventional tablets are available in 6 pieces in blister; 5, 2 or 10 of the blisters in a carton.

Blisters (also 6 tablets) cherry and mint Gustav contained in a cardboard box in an amount of 4 and 8 pieces.

Pharmacological action

Gastal has antacid action .

Pharmacodynamics and pharmacokinetics

Gastal refers to a group of medicines called buffering antacids . It increases the pH of the gastric juice and eliminates the discomfort caused by the increase in acidity (abdominal pain, heartburn).

Antacid effect   the drug sold by neutralizing gastric acid, a long and rapid impact. One tablet gastal capable of neutralizing the hydrochloric acid number of 21, 5 mmol.

Aluminum hydroxide-magnesium carbonate gel   - Antacid buffering substance that lowers the acidity of gastric juice to the level (pH 3-5) and normalizes the process of digestion. Aluminium hydroxide   inactivates pepsin Contained in the gastric juice.

Magnesium hydroxide   - Unbuffered antacid is not absorbed in the intestine. Quickly neutralizes acidity, has a laxative effect. The complex magnesium hydroxide   and aluminum hydroxide   It allows activation of the antacid effect and reduces the risk of side effects specific to each component separately (eg constipation   after use of aluminum compounds or loose stools   after using magnesium compounds).

Antacid effect occurs almost immediately after taking the pill Gustav and lasts about two hours. The drug is inactivated lysolecithin, pepsin   and bile acid .

Gidrookisid aluminum   intensifies regenerative and protective processes in the gastric mucosa. After reaction with hydrochloric acid   stomach in an alkaline medium is reacted with carbonates   and phosphates . In the form of insoluble salts excreted in the feces. Magnesium hydroxide   after chemical transformations also excreted in the feces in the form of insoluble salts.

Indications Gastal

Often, patients are asked, from what helps Gastal? Speaking ordinary language, indigestion . heartburn Pain and discomfort in the stomach - it's something from which tablets Gastal well help.

Clinical indications for Gustav are:

• phenomena dyspepsia Such as epigastric pain, heartburn Discomfort, acid regurgitation after drinking coffee, errors in diet, nicotine, as well as emerging after taking a number of drugs;
• diseases characterized by an increased acid production: gastritis . stomach ulcer . reflux esophagitis .

Contraindications

General contraindications for all forms of release Gustav:

• hypersensitivity   to compounds magnesium aluminum   or other components of the drug;
• severe renal failure;
• Children under 6 years of age;
• hypophosphatemia ;
• Alzheimer's disease ;
• diseases associated with metabolic disorders lactose .

Caution is advised to take the drug in patients with chronic renal failure, adults and children from 12 years weighing less than 50 kg, for children from 6 to 12 years.

Side effects

• The stomach and intestines: constipation . nausea . diarrhea . vomiting , Discoloration of feces.
• For the skin: sensitization reactions ( hives . itch . dermatitis . angioedema   and anaphylaxis ).

When using the drug in recommended doses, these side effects develop very rarely.

• With long-term use of the drug in high doses may decrease the concentration Phosphorus   in the body, enhancing the processes decalcification   in bone tissue, osteomalacia, giperalyuminiemiya, gipermagniemiya.
• In people with kidney disease may increase plasma concentrations   aluminum and Magnesium . This can lead to the development of   encephalopathy   and dementia .
• Aluminium hydroxide   dangerous for patients suffering porphyria   and passing hemodialysis .

Instructions for use Gastal

Instructions for use Gustav prescribes how to take the drug in tablets with a cherry and mint flavor in conventional tablets. Pregnancy and lactation are not strict contraindications to treatment.

Adults and children over 12 years weighing more than 50 kilograms prescribed to dissolve 1 or 2 tablets 4-5 times a day an hour after a meal and at bedtime, the maximum daily dose is 8 tablets. The course of treatment not be longer than 2 weeks.

With heartburn   Gastal be taken in similar doses, regardless of the meal.

Adults and children from 12 years weighing less than 50 kg, for children 6-12 years of age should consume half the standard dose. The treatment should not be longer than 2 weeks.

In individuals with chronic kidney disease   Correction dose and frequency of admission is not required.

Overdose

The use of high doses can cause vomiting . nausea . diarrhea . decreased appetite . constipation .

With long-term use of high doses may occur Gastal hypocalcemia, hypophosphatemia, hypercalciuria,   muscle weakness, fatigue, Arrhythmia . osteoporosis . osteomalacia, giperalyuminiemiya, gipermagniemiya, encephalopathy, nephrocalcinosis.

Signs of overdose are wasting, facial flushing, changes in behavior. It is also possible to develop m etabolicheskogo alkalosis , Changes in mental alertness, muscle aches, nervousness, fatigue, changes in taste sensitivity.

Treatment: removal of the drug, gastric lavage, Activated Carbon In severe cases - Rehydration, forced diuresis . In case of overdose in patients with renal insufficiency is necessary to conduct peritoneal dialysis   or Hemodialysis .

Cooperation

There is a weakening of absorption from the gastrointestinal tract of drugs taken at the same time Gastalom. Therefore, between the intake of various drugs need to take a break.

During the two hours before or two hours after taking Gustav should be: H2 antihistamines, ethambutol, isoniazid , Anti-TB drugs,   metoprolol, atenolol, propranolol, chloroquine, cyclones, diflunisal, digoxin, fexofenadine, diphosphonates, fluoroquinolones, sodium fluoride,   glucocorticoid drugs kayeksalat, indomethacin, ketoconazole, lincosamides, lansoprazole, phenothiazines, neuroleptics, phosphorus, penicillamine, thyroxine .

Gastal activating effect nalidixic acid   and levodopa   and slows down the action tetracyclines . ciprofloxacin . ofloxacin . isoniazid . acetylsalicylic acid , Preparations   iron naproxen . cardiac glycosides.

In an application with Gustav salicylates   increased excretion of last kidneys.

Do not use the drug at the same time quinoline .

When used with quinidine   violated its excretion especially in patients with renal insufficiency may develop quinidine toxicity.

The simultaneous use of Gustav and citrate   It leads to an increase in the level of aluminum   in blood.

The drug reduces the adsorption folic acid .

Pirenzepine   It extends and enhances the action of Gustav.

Terms of sale

In most countries the drug is available without a prescription.

Storage conditions

Keep away from children. Store at temperatures not above 25 degrees.

Shelf life

3 years.

Cautions

Aluminum hydroxide   may cause constipation , a magnesium hydroxide   - Intestinal hypomotility. Application Gustav in large doses can cause or intensify ileus , Especially in patients with renal impairment, or the elderly.

Consult with your doctor if after treatment became apparent weight loss, constant discomfort in the abdomen, and difficulty swallowing, indigestion.

Compounds aluminum   poorly absorbed in the gut, however, excessive or long-term use of the drug may reduce the concentration Phosphates   in the body, which is accompanied by an acceleration of processes resorption   bone and appearance hypercalciuria   with an increased risk of osteomalacia .

Prolonged use gastal patients with renal failure leads to an increase in plasma concentrations of aluminum   and Magnesium   - It may be the cause of dementia . encephalopathy . microcytic anemia .

It is not recommended to use the drug for more than 2 weeks without a prescription.

The preparation contains lactose So persons with congenital problems of sensitivity galactose   or a violation of its suction forbidden to take Gastal.

Analogs

Gastal (INN - + magnesium hydroxide, hydrotalcite ) Is positioned among the broad masses of the population (especially in advertising) as a remedy for heartburn. There are other tablets from heartburn: Maalox . Remmaks-HF . The price is comparable to the price of analogues Gustav.

Analogs of the drug in other forms of production: Almagel   (suspension) Fort Akrepat e (suspension).

Babies

Children under 6 years of age should not take Gastal.

Gastal during pregnancy

Often heard the question whether it is possible to use during pregnancy Gastal? In pregnancy, the instruction does not prohibit taking the drug, but this should be done with caution, consult a doctor.

It should be noted that the drug is able to influence the intestinal motility: magnesium hydroxide   may cause diarrhea And compound   aluminum   promotes constipation Which often occur during pregnancy.

At the time of treatment Gastalom should suspend breast-feeding.

Reviews Gastale

Reviews Gastale in overwhelmingly positive. Among the advantages of the most frequently noted the speed of action, duration of effect, save, pleasant taste.

Price Gastal

24 pills Gustav in Russia will cost from 122 to 155 rubles. In Ukraine, the price of Gustav will be an average of 35 hryvnia.