Description overdue on 06/19/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use of Nexium (dosage and method)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

As part of the tablets esomeprazole magnesium trihydrate   22, 3 mg or 44 mg + 5 adjuvants ( giproloza, E172, magnesium stearate, glycerol monostearate, hypromellose, triethyl copolymer, ethacrylic acid and methacrylic acid, macrogol, crospovidone, paraffin, polysorbate 80, sodium stearyl fumarate, macrogol, E171, sucrose, talc ).

Weight for solution:   esomeprazole   40 mg + sodium hydroxide   and dihydrate, disodium edetate .

Product form

Nexium 20 mg   and Nexium 40 mg   - Coated tablets, oblong convex. Color - pink, 20 mg - light, 40 mg-dark. On one side of the tablet dosage engraved in the other - an inscription A / EH or A / EI. Packaging cardboard 7, 14, 28 pieces.

Powder - pressed white mass for solution. In glass vials of 5 ml.

Pharmacological action

A proton pump inhibitor.

Pharmacodynamics and pharmacokinetics

The active ingredient is a derivative omeprazole   (him S-isomer ).   Esomeprazole   reduces the activity of secretion hydrochloric acid   on the gastric mucosa, by inhibiting proton pump   (enzyme H + K + -ATPase ) parientalnyh cells   on the walls of the stomach.

When combined and antibiotics , Effective against Helicobacter pylori As a rule, the cause of stomach ulcers .

As a specific response to the reduction of acid secretion, can be formed benign cyst Increasing the level of gastrin   in plasma.

After 1-2 hours after taking the drug are already beginning to have an active influence on the level of hydrochloric acid. About 90% of the active ingredient gets engaged to plasma proteins. Metabolized, excreted in the urine and feces.

Pharmacokinetics   in people with reduced activity enzyme CYP2C19   and severe liver disease is characterized by a core group of people. It is necessary to make a correction dose of medication.

Indications

Pills:

• erosive esophagitis reflyus , Treatment and supportive care;
• peptic ulcer   (treatment and prophylaxis in combination with other agents);
• pathological hypersecretion   gastric glands;
• persons who take a long time NSAIDs   and treatment of diseases caused by their reception;
• prevention and treatment of bleeding peptic ulcers ;
• idiopathic hypersecretion.

The solution for intramuscular injection is prescribed if it is impossible to take tablet form of the drug.

The indication is:

• gastroesophageal reflux disease ;
• peptic ulcers Including prevention of bleeding after the spent endoscopic hemostasis .

Contraindications

The drug is contraindicated:

• patients Allergies At which any of the components, including fructose (for tablet forms);
• when receiving atazanavir   or nelfinavir ;
• children under 12 years.

When gastroesophageal reflux disease   the drug may be administered to children older than 12 years.

Weight renal failure   not a direct contraindication to the use of drugs, but in this case care should be taken.

Side effects

• nausea, headache, constipation , Pain epigastric ;
• allergic reactions   on the skin, disturbance of sleep patterns, paresthesia ;
• bronchospasm, stomatitis, anaphylactic shock, myalgia, agitation, arthralgia ;
• possible inflammation and redness at the injection site at Intravenous   and Intramuscular   use.

Instructions for use of Nexium (dosage and method)

Tablets drink wholly or dissolved in water without gas. If necessary dissolution of the tablet can be introduced through Levin tube .

How to take before or after meals?

According to the instructions for use of Nexium food intake does not affect the efficacy of the product. In the treatment and prevention ulcers As a rule, the daily dose is 20 mg, divided into two doses in combination with other agents. The course is 7 days.

During the kislotopodavlyayuschey therapy   prescribe Nexium 40 mg, every day for a month.

In states induced by administration NSAIDs Daily dosage is 20-40 mg. Course- to two months.

In severe liver disease daily dose should not exceed 20 mg.

The dosage for children (12+)

At erosive esophagitis reflyus   daily dose of 40 mg for one time, one month. In other cases it is sufficient receiving 20 mg agent per day.

Intramuscular injections

If desired, instead of the tablet form of the drug may be given injections or intravenous infusion . Dosage point. Time intramuscular administration should be not less than three minutes.

IV - from 10 minutes to an hour. The drug is diluted 0, 9% solution of sodium chloride ohms, without mixing with other drugs.

Keep the drug can be cooked no more than 12 hours, it is best to use it immediately after preparation.

Overdose

People consume 0, 28 grams of the drug was observed weakness and discomfort gastrointestinal tract .

The drug has no specific antidote . Treatment is symptomatic.

Cooperation

When combined   esomeprazole   with type drugs ketoconazole   and itraconazole It can disrupt the absorption of drugs GI .

Atazanavir, nelfinavir, omeprazole   when combined with Nexium become less effective. However, when combined with saquinavir Its concentration in serum increases.

Simultaneous treatment with agents involved in the assimilation of which CYP2C19 It leads to their impacts. These drugs include imipramine, diazepam, clomipramine, citalopram, phenytoin .

For persons suffering   epilepsy Should be cautious in making agent. Medicines for epilepsy ( phenytoin ) Poor combined with Nexium.

Precautions to combine the drug with warfarin   and cisapride .

Terms of sale

We need a recipe.

Storage conditions

Dark, cool place, away from children.

The vial with powder stored in the original packaging, in the light - no more than a day.

Shelf life

3 years - tablets.

2 years - powder for solution.

Analogs of Nexium

The drug can be replaced? In fact, drugs are synonymous: Nekspro, Ezoksium, Ezoneksa, Ezoks, Ezolong .

The most common counterparts: Ezomealoks, Emanera, Barolo, esomeprazole, Veloz, Geerdin, Kontrolok, Ozol, Omez, Normitsid, Rabimak, Panum, Pariet, will pour, Ultop .

Price analogs may differ significantly from the original.

Is it better or Pariet Nexium?

The whole question of the use of a vehicle shall be determined individually, depending on the test results, the body's sensitivity to a particular facility. However, among the experts view the home that Pariet more effective than Nexium. Its effect is faster, less daily dosage, and side effects are rare. Both tools are not cheap, it is entirely justified by their performance.

Reviews of Nexium

Doctors about Nexium : At all proton pump inhibitors - The most effective drugs currently regulating acidity gastrointestinal tract . Nexium - very good preparation of this series, with the expressed a strong therapeutic effect.

Reviews on the forums good. The drug effectively, relief comes quickly. Side effects occur infrequently. The disadvantage is considered to be high cost.

Price Nexium (Where to buy)

Price tablets Nexium 40 mg   about 1750 rubles per 14 pieces.

Cost Nexium 20 mg   in Moscow is 1310 rubles per 14 pieces.

Buy Pellets   and granules   the drug can be for 2061 rubles per 10 mg, 28 pieces.