Description overdue on 04/15/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The composition of one tablet Nolpaza 20 includes 20 mg Pantoprazole sodium   (recalculated on pantoprazole ), and sorbitol . mannitol . crospovidone . calcium stearate . anhydrous sodium carbonate,   as auxiliary substances.

The composition of one tablet 40 includes Nolpaza 40mg Pantoprazole sodium (counting on pantoprazole) and similar excipients.

Product form

Available in the form of oval, slightly biconvex tablets, which covers a light brown-yellow film coating. At the turn of the tablet is rough, it is white to light yellow. Produced in blisters 14 pcs, realized in cardboard boxes 1, 2 or 4 in each package.

Pharmacological action

Nolpaza is hypoacid drug Within the group of proton pump inhibitors. In its structure there is the active ingredient - pantoprazole And a derivative benzimidazole . This substance inhibits the activity of H + / K + ATPase. Once in the acidic environment of the active component Nolpazy converted into pharmacologically active form and provides blocking of the last stage hydrophilic HCl secretion in the stomach. Basal and stimulated production of hydrochloric acid inhibited drug is equally active. Use of the drug leads to increased secretion gastrin However, this phenomenon is reversible.

Pharmacodynamics and pharmacokinetics

The drug is administered orally, whereupon its active ingredient is rapidly absorbed into the bloodstream. The bioavailability of the active substance - 77% of the meal, it is not dependent. Maximum plasma concentration observed after 2-2.5 hours after drinking Nolpazy inside.

A characteristic feature of the drug is a high level due to blood proteins - about 98%. The drug is metabolized in the liver, its removal occurs as metabolites in the urine, a small part - with feces. Pantoprazole half-life - 1 hour, a metabolite derived after 1, 5 hours.

Patients suffering from impaired liver function, it is necessary to adjust the dose of a medicament. Older patients and patients suffering from renal impairment, the dose is not adjusted.

Indications

Before starting treatment, you must clearly know from which tablets are used. Indications Nolpazy following:

• gastroesophageal reflux disease   mild;
• reflux esophagitis   varying degrees of (prevention and treatment);
• peptic ulcer of the stomach and duodenum ;
• state, provoke hypersecretion ( Zollinger-Ellison   and etc.);
• eradication Helicobacter pylori   (given in combination with antibiotics).

In addition, the indications for use of the drug is, if you need a prophylactic to prevent the development of ulcerative lesions of people receiving long-term treatment with non-steroidal anti-inflammatory drugs.

Contraindications

Contraindications Nolpazy following:

• High sensitivity to the components of the preparation (fructose intolerance, etc.).
• Nolpaza 40mg does not apply with antimicrobial agents for the treatment of patients with severe kidney disease and / or liver.
• Do not take the drug to people with neurotic dyspepsia .

The drug is prescribed with caution:

• People suffering liver disease . If the treatment is carried out for a long time, be sure to monitor the patient liver enzyme levels.
• Those who are at high risk of developing ulcers , Intestinal, stomach bleeding .
• Patients at high risk for B12 hypovitaminosis .

Side effects

Typically, the drug does not cause undesirable effects. Sometimes, however, you experience the following side effects:

• The functions of the digestive tract : Violation of a chair, stomachalgia . flatulence . nausea . elevated liver enzymes . Rarely observed hepatotoxic influence . jaundice Sometimes - jaundice, which is accompanied by liver failure.
• The functions of the central nervous system : dizziness . headache . emotional lability . visual impairment.
• The functions of the urinary system : Appearance edema . interstitial nephritis .
• Might appear   allergic reactions : itching . skin rashes . hives . Sensitivity . Rarely develops angioedema .
• In some cases, there is myalgia , Increased body temperature, marked hypertriglyceridemia .

Instructions for use (method and dosage)

The drug is administered orally. Instructions on Nolpazu 40 mg and 20 mg following: swallow the medicine you need is not liquid, drink plenty of fluids. The drug is optimally taken before meals. If your doctor has prescribed reception Nolpazy 1 tablet a day, it is best to take it in the morning. Detailed instructions for use Nolpazy and dosage is determined by the physician on an individual basis.

People with mild gastroesophageal reflux disease Usually assigned Nolpaza 20 mg, not more than one tablet per day. The treatment lasts from 14 days to 1 month, sometimes the doctor decides to extend the treatment for 2 months.

In the treatment of acute reflux esophagitis And assigned to prevent medicament for 20mg once a day. If there is a high probability of recurrence of the disease, increase the dose to 40 mg 1 time a day. When the condition improves, the dose again reduced to 20 mg. Adults who receive non-steroidal anti-inflammatory drugs, take Nolpazu to prevent ulcers (20 mg 1 time per day).

The eradication schemes Helicobacter pylori   Nolpaza appointed on 40 mg twice a day, while receiving the drug should be combined with the consumption of antimicrobial agents. Tablets need to drink in the morning and evening.

Those patients who are suffering Zollinger-Ellison syndrome   and other diseases that are accompanied by increased secretion, originally appointed by 40 mg twice a day, if necessary, the dose may be increased to 80 mg daily.

If a person has disorders of the liver , The day he can take no more than 20 mg of pantoprazole. Before starting treatment with, it is necessary to go through research and to exclude the presence of a malignant tumor in the esophagus and stomach.

Overdose

Information about overdose has been reported. The drug was well tolerated even at high doses. If a person feels bad, it is necessary to carry out gastric lavage, take chelators, conduct symptomatic treatment.

Cooperation

If you combine the drug and ketoconazole   and other means with a pH-dependent absorption, bioavailability of the latter decreases.

If taken with Nolpaza coumarin anticoagulants , The effectiveness of the latter may vary.

When combined with the reception Nolpazy antacids , The pharmacokinetics of these funds does not change.

Terms of sale

Sold in pharmacies by prescription.

Storage conditions

Keep the drug should be in a dry place, protected from light exposure. Storage temperature should be between 15 to 30 degrees.

Shelf life

Store the drug can be 2 years.

Cautions

Before treatment it is necessary to exclude the presence of the patient Cancer tumors As in the treatment of the symptoms can be masked, and therefore the diagnosis will not be made in a timely manner. If a month later the patient will not appear on the results of treatment, it needs to undergo another examination. If you need long-term treatment required regular monitoring by a doctor. In reaction time, work with machinery and transport management Nolpaza not affected.

Analogs

The drug Nolpaza, analogues of which are realized in pharmacies, sometimes in the course of treatment may be replaced by other means. Structural analogs of the active substance are the following drugs: kontrolok . peptazol . zipantola . Pantazi . puloref . krosatsid . sanpraz . panum . ultera .

The price of analogues of the drug varies from 80 to 600 rubles. Analogs have similar productivity and may be appointed instead of Nolpazy only after approval by the attending physician.

  Omez or Nolpaza - which is better?

Omez   - Antiulcer agent group of proton pump inhibitors with the active substance omeprazole. A formulation as Nolpaza effectively reduces hydrochloric acid. As the patient testimonials, Nolpaza act more quickly and efficiently.

Which is better: omeprazole or Nolpaza?

Omeprazole   also refers to the group of proton pump inhibitors and suppresses the secretion of hydrochloric acid. Effect of the drug is also effective, but omeprazole and Nolpazu interchanged without the approval of a doctor should not be.

  Nolpaza or Ultop - which is better?

The active ingredient of the drug Ultop   also is omeprazole. There are a number of contraindications for its administration, in particular, the drug is not used to treat children under 12 years. Determine which drugs are effective - or Nolpaza Ultop, only a doctor can, taking into account the individual characteristics of the patient's health.

Synonyms

Pantazi . Peptazol . Sanpraz .

Babies

Nolpaza not used for the treatment of children and adolescents under 18 years of age, as there are still no data on the safety of this treatment and its effectiveness.

With alcohol

Clinical trials have not shown significant effects of the drug with ethyl alcohol. However, Nolpaza and alcohol are incompatible, because the alcohol can not be used for diseases that are treated with this drug.

During pregnancy and lactation

Now there is no sufficient experience Nolpazy use during pregnancy and lactation. Means may appoint a pregnant woman doctor before a clear assessment of benefit to women, and the risk to the fetus. Treatment Nolpazoy during pregnancy is held in minimum doses and for a short period. No data on the contact of the active substance in the milk. Before treatment during lactation is necessary to consult a doctor. It may be necessary to interrupt the feeding.

Reviews on Nolpazu

As reviews of doctors per pill Nolpaza and reviews in the forums mostly positive. Patients say that the positive effects of treatment usually appear after long-term treatment facilities.

In particular, there is a positive effect in the treatment of stomach ulcers , Pain in the stomach during a gastritis . According to patients, the drug effectively removes the feeling of heaviness in the stomach. Significant side effects were observed.

Price Nolpazu where to buy

The average price for the 20 mg tablet Nolpaza is 120-140 rubles. (package of 14 pcs.). Buy Nolpaza tablets 40 mg can be as low as 180-210 rubles. (package of 14 pcs.). Price in Ukraine tablets 20 mg equals the average of 40-50 UAH. Nolpaza value of 40 mg is 60-70 UAH.