Description overdue on 25.03.2012

Proton pump inhibitors. The drug blocks the final step of isolating the hydrochloric acid in the stomach. Omeprazole is a prodrug which is converted to the drug in an acidic environment. Regardless of the nature of the stimulus and drug reduces stimulated basal secretion . Antisecretory effect is manifested in an hour after administration of 20 mg of medicament. Omeprazole is available as a powder, tablets, capsules.

Indications and contraindications:

Omeprazole prescribed for   peptic ulcer   digestive system, for the prevention of relapse in hypersecretory states, reflux esophagitis , Stress ulcers of the digestive tract, NSAID-gastropathy, systemic mastocytosis , Multiple endocrine adenomatosis, to eradicate Helicobacter pylori in patients with peptic ulcer of the gastrointestinal tract. Omeprazole is not prescribed for diseases of the kidneys and liver, pregnancy, pediatric practice, in case of hypersensitivity.

Side effects and overdose:

The digestive tract: increase in liver enzymes, disorders of the chair (a combination of diarrhea   and constipation ), Epigastric pain, flatulence, nausea, violation of taste perception, hepatitis, hepatic disorders in the system. Bodies of blood:   pancytopenia , Agranulocytosis, leukopenia. Nervous system:   encephalopathy in patients with liver disease, depression, agitation, headache, dizziness. Musculoskeletal system:   myalgia, myasthenia gravis, arthralgia . Omeprazole can cause allergic reactions, alopecia, rash, fever, bronchospasm , Anaphylactic shock, discomfort, gynecomastia, peripheral edema, Eichhorst's neuritis , Disorders of vision, increased sweating. If overdose is marked arrhythmia, tachycardia, nausea, headache, dry mouth, blurred vision, confusion. Treatment posindromnoe, hemodialysis ineffective.

Mode of application:

Omeprazole capsules are taken by mouth in the morning of the day, be sure to wash down with water. NSAID-gastropathy, reflux esophagitis, peptic ulcer exacerbation: 20 milligrams once a day. The duration of treatment is 2-3 weeks. With Zollinger-Ellison syndrome taking 60 mg, in severe cases, appoint 80-120 mg. Eradication of Helicobacter pylori: triple therapy for a week - 500mg clarithromycin, amoxicillin 1 g, omeprazole 20 mg 2 times per day. Patients in the pathology of the liver, kidney, reduce the dosage by half.

Special instructions:

The doctor before prescribing the drug Omeprazole should exclude the presence of malignant tumors. Simultaneous food intake has no effect on drug efficacy.

Drug Interactions:

Omeprazole reduces the absorption of iron salts, esters of ampicillin ketoconazole . itraconazole . The drug can cause an increase concentration and reduce the excretion of phenytoin, anticoagulants , Diazepam. Antacids do not affect the pharmacology of omeprazole.