Description overdue on 01/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Omez JEM (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Part Omez JEM   includes active substances omeprazole   and domperidone Both substances - in the form of pellets. As additional ingredients, the formulations accommodates lactose, mannitol, anhydrous sodium hydrogen phosphate, sodium lauryl sulfate, hypromellose, sucrose, sodium hydroxide, methacrylic acid copolymer (type C), purified water, titanium dioxide, macrogol, talc purified cellulose, ethyl cellulose, sugar grits nonpareil, silicon colloidal silica, iron oxide red, yellow iron oxide, triacetin.

Product form

Omez JEM is available in the form of gelatin capsules transparent, which has a black logo and the inscription «Dr. Reddy's ». The main body of the capsule - a red inscription «Omez-Dsr». Inside the capsule contains spherical pellets, which may have a shade from yellow-white to grayish. The blisters are packed in 10 capsules, blisters are put in a cardboard box.

Pharmacological action

This combined drug which promotes inhibition of gastric acid secretion and regulates the motor function of the gastrointestinal tract.

Omeprazole   - A proton pump inhibitor, antisecretory drugs. Activated substance in an acidic environment. Under its influence there is a blocking of the last stage of transportation of hydrogen ions. As a result, it inhibits the secretion of acid.

Domperidone   - A peripheral dopamine receptor antagonist. Under its influence the processes regulated by smooth muscle of the stomach and small intestine. Due to the influence of domperidone increases the duration and frequency of contractions of muscles, and the contents of the stomach more rapidly passes through the stomach and small intestine. The substance increases the pressure of lower esophageal sphincter. Domperidone has antiemetic effects.

The combination of omeprazole and domperidone beneficial effect on the motility of the stomach and intestines, and the acidity of gastric juice.

Pharmacodynamics and pharmacokinetics

Domperidone is absorbed by 93%, falling into the gastrointestinal tract, absorption is very fast. Thus oral bioavailability agent is 13-17%.

The highest concentration of the substance in the blood was 90 minutes after oral administration and does not change during the period of administration. Blood proteins binds domperidone 90%. It is metabolized in the liver. Because the body is derived through the kidneys and intestines. The half-life is 7-9 hours.

Omeprazole after oral administration is absorbed very quickly. Its bioavailability - 65%. The highest concentration of substances in the body is observed after 1 hour. The plasma protein material binds 95%. It is metabolized in the liver. The bulk of the metabolites excreted in the urine, still about 18% - with the feces.

Indications

Omez JEM is used to treat and relieve the symptoms of gastroesophageal reflux disease.

Contraindications

No drug treatment is practiced in such diseases and conditions:

• elevated levels of prolactin   body ( prolactinoma );
• bowel obstruction;
• bleeding in the stomach or intestines;
• any condition in which activation of GI motility may worsen the state of health;
• pregnancy . breastfeeds ;
• children's age;
• hypersensitivity to the active ingredients of the drug.

Side effects

Omez JEM could trigger the development of the following adverse reactions:

• itch . hives Other allergic reactions ;
• galactorrhea   women;
• gynecomastia and deterioration potency   men;
• dry mouth;
• symptoms of gastrointestinal dysfunction;
• dizziness . insomnia , Paresthesia, agitation, depression ;
• myalgia, arthralgia, blurred vision, swelling;
• fever , Malaise;
• bronchospasm;
• encephalopathy , Hepatic failure in people who have previously suffered from liver disease.

Instructions for use Omez JEM (method and dosage)

If the patient has been assigned a drug Omez JEM instructions for use must be clearly demonstrated to them. The drug must be taken orally, the morning one hour before a meal. Appointed usually 1-2 capsules. At the same time they must be swallowed whole without chewing. Guide indicates that the highest dose of the drug per day should not exceed 80 mg (payment on domperidone).

Older patients may not reduce the dose of the treatment. Caution should be given the means to people with liver disease, because the metabolism of active substances takes place in the liver. Also wary appoint patients with severe kidney disease.

The course of drug administration may last for 4 weeks.

Overdose

In case of overdose of domperidone can be drowsiness, disorientation, sleepiness occur, disorientation, and extrapyramidal disorders may occur. If you notice any of these signs of symptomatic treatment. If extrapyramidal disorder observed, shows the use of anticholinergic drugs, which are used in the therapy of Parkinson's disease.

Cooperation

Omeprazole while admission increases the plasma concentrations of phenytoin, diazepam, and anticoagulants.

Omeprazole may also influence the bioavailability of the drug, absorption of which is related to pH. Omeprazole prevents degradation of drugs that are sensitive to acid.

In simultaneous treatment with itraconazole or ketoconazole and omeprazole can cause a decrease in the rate of absorption of other drugs.

Effect of domperidone can neutralize anti-cholinergic drugs.

The bioavailability of domperidone when treating both antisecretory and reduce Antacid agents

Domperidone reduces gipoprolaktinemiyu, which manifests itself in the treatment of bromocriptine.

Domperidone concentration in blood increases when concomitantly with azole antifungal agents, HIV protease inhibitors, macrolide antibiotics.

Terms of sale

Omez JEM can be purchased by prescription.

Storage conditions

Protect drug from moisture and light, stored at a temperature of 25 degrees Aim.

Shelf life

Shelf life - 2 years.

Cautions

It is necessary to eliminate the malignant disease, and other serious diagnoses before the start of the treatment, as the drug may mask the symptoms of these diseases and complicate diagnosis.

In the treatment with medicines that reduce the level of acidity, can increase the risk of gastrointestinal infections provoked by certain microorganisms, (Campylobacter, Salmonella).

People with pheochromocytoma in the treatment increases the probability of developing hypertensive crisis.

On the ability to focus drug treatment has no effect.

Analogs

Analogs Omez JEM - a drug with the same active ingredients: Omez D . Gastrozol . Omeprazole .   Vero Omeprazole . Demeprazol . Omez   and etc.

Babies

Contraindicated used to treat children this drug.

During pregnancy and lactation

There is no exact information about the safety of the drug for pregnant   and nursing mothers . Therefore, under these conditions Omez JEM does not apply.

Reviews

Reviews Omez JEM evidence of its effectiveness. The drug quickly relieves symptoms of gastroesophageal reflux disease. Patients taking the drug for a long time, there is a marked improvement in health status.

Price, where to buy

The cost of the package of 30 pieces. Omez JEM - an average of 300 rubles.