Description overdue on 02/27/2013

Antiulcer agents . In its composition contains three active components - omeprazole and clarithromycin, tinidazole. The drug has anti-ulcer and anti-microbial effects. Under the action of omeprazole decreases the secretion of hydrochloric acid and the acidity (by inhibiting specific enzyme, located in the membranes of cells parientalnyh mucosal wall of the stomach), and reduced levels of stimulated basal secretion . Oral administration of omeprazole inhibits gastric acid secretion in an hour, the effect persists for days. Reduced gastric acidity by 97% achieved again taking 20 mg of omeprazole during the day.

The second component of the drug is Pilobakt clarithromycin   - Semisynthetic derivative of erythromycin A, antibiotic group macrolides It acts on Helicobacter pylori, anaerobic bacteria, Gram-positive and Gram-negative flora. The third component of the drug Pilobakt - tinidazole; It acts on Giardia, amoeba, Trichomonas , Helicobacter pylori, agents of anaerobic infections, has antiprotozoal effect. Pilobakt AM additionally contains in its composition amoxicillin (antibiotic). Pilobakt NEO used for H. pylori triple therapy. The drug is available in tablet form and as a set of capsules.

Indications:

Drug Usage Pilobakt recommends prescribers with ulcers of the digestive tract (stomach, duodenum) to eradicate Helicobacter pylori.

Contraindications:

Pilobakt not prescribed for porphyria , Breastfeeding, chronic hepatic system, intolerance active components (omeprazole, tinidazole, clarithromycin, for Pilobakt AM - amoxicillin), while carrying a pregnancy, severe course of renal, liver failure while taking ethanol (increases the risk of disulfiramopodobnyh reactions), children under achieving the age of twelve.

Side effect:

Part of the preparation Pilobakt Omeprazole can cause headaches, flatulence, diarrhea syndrome, weakness, dizziness, epigastric pain, constipation, nausea, thrombocytopenia, hepatic enzyme elevations system eozinotsitopeniyu , Neutropenia, leukopenia, skin rash. Tinidazole may cause cholestatic jaundice , Gastralgia, nausea, headache, allergic reactions such as itching and rashes pseudomembranous enterocolitis , Diarrhea, vomiting, secondary stability of the microbial flora. Side effects of tinidazole: itching, vomiting, leukopenia, a bad taste in the mouth, disturbances of appetite, headaches, hives.

Mode of application:

Pilobakt taken orally. Each blister contains 2 capsules at a dose of 20 mg of omeprazole, tinidazole 2 tablets at 500 mg and 2 tablets of clarithromycin 250 mg. Each blister is designed for 1 day course anti-ulcer therapy. According to the instructions you need in the morning, take 1 capsule of omeprazole, tinidazole and 1 tablet 1 tablet of clarithromycin (capsules and tablets are placed in the orange part of the blister), the procedure is repeated in the evening (capsules and tablets are placed in the blue part of the blister). Each package contains 7 blister calculated on weekly rate of anti-ulcer therapy. After completion of treatment it is recommended to take a period of three weeks of omeprazole 20 mg per day.

Special instructions:

Tinidazole may cause staining of urine a dark color. Throughout the course of anti-ulcer therapy requires a complete rejection of the receiving alcoholic beverages because of the risk of disulfiramopodobnyh reactions . In chronic liver disease of mandatory periodic monitoring of liver enzymes. Before starting treatment your doctor to rule out malignancies (omeprazole may mask clinical signs of cancer). Responses to the drug Pilobakt show the effectiveness of the drug in protivoyavzennoy therapy. Price Pilobakt averages 800-1000 rubles depending on the pharmacy network.

Drug Interactions:

Clarithromycin, a part of the drug Pilobakt can cause increased levels of theophylline, terfenadine in the blood (ECG recorded prolongation of the interval QT). Increased drug effect is observed in concurrent therapy with oral forms anticoagulants . In the treatment of digoxin, astemizole, phenytoin, carbamazepine, cisapride, pimozide, valproate, lovastatin, disopyramide, cyclosporine   there is an increased concentration of the above drugs. Omeprazole can reduce the rate of metabolic processes while taking diazepam and phenytoin. Pilobakt reduces the absorption of iron salts (decrease acid production in the stomach), ampicillin ketoconazole .