Description overdue on 03.11.2011

Antiulcer drugs. Under the effect of reducing the overall volume of Ranitidine gastric secretion, decreased number   pepsin   in the stomach. The drug blocks histamine H2 receptors on mucosal cells of the stomach wall, thereby reducing the production hydrochloric acid . Antisecretory effect of the drug has a beneficial effect on the healing of ulcers in the stomach and duodenum 12. Ranitidine improves microcirculation, strengthens reparative processes, increases the production of mucous substances. Formulation: effervescent tablets, coated tablets, solution (in / in / m).

Indications:

Ranitidine prescribed for ulcerative lesions of the gastrointestinal tract, erosive esophagitis . reflyuksezofagite . Zollinger-Ellison syndrome . The drug is prescribed for the prevention of gastric aspiration before surgery under general anesthesia, aspiration pneumonitis. Ranitidine is used in the treatment of rheumatoid arthritis .

Contraindications:

Ranitidine is not indicated during lactation. Patients with cirrhosis   liver, acute porphyria, kidney disease, portosystemic encephalopathy, liver failure prescribed with caution. Do not use in pediatrics, pregnancy.

Side effect:

Gastrointestinal tract : Dry mouth, dyspepsia, epigastric pain, constipation , Elevated liver enzymes. Less celebrated acute pancreatitis , Cholestatic, hepatocellular or mixed hepatitis. Forming Organs : Immune hemolytic anemia , Aplasia (or hypoplasia) of the bone marrow, pancytopenia, agranulocytosis, thrombocytopenia . leukopenia . Cardiovascular system : Arrhythmia, drop in blood pressure, bradycardia, asystole, atrioventricular block . Nervous system : Drowsiness, tinnitus, confusion, hallucinations , Irritability, involuntary movements. Senses : Paresis of accommodation, blurred vision. Locomotor apparatus : myalgia , Arthralgia. Endocrine system : Gynecomastia, hyperprolactinemia , Decreased libido / potency, amenorrhea . Allergies: bronchospasm, anaphylactic shock, erythema multiforme, skin rash. Acute porphyria increase glutamattranspeptidazy, hypercreatininemia, alopecia .

Mode of application:

B / in slowly renitidin 50 mg diluted in 0.9% NaCl solution, administered over 5 minutes. If necessary, the administration can be repeated after 6-8 hours. At intravenous drip speed is 25 mg per hour.
Intramuscular administration of 4 times daily at 50 mg. Prevention Mendelson syndrome: 150 mg the night before and two hours before general anesthesia. Women in childbirth: every 6 hours at 150 mg. Ulcerative lesions of the gastrointestinal tract in the acute period: Twice a day, 150 mg or 300 mg at night. Course: 4-8 weeks. Zollinger-Ellison syndrome : Initially 150 mg three times a day. In some cases, the dose was increased to 6 g per day.

Overdose:

Manifested ventricular arrhythmia (introduced Lidocaine ) bradycardia   (administered atropine ), Convulsions (diazepam prescribed in / in). Hemodialysis is effective.

Special instructions:

Doctors important to remember that for the treatment of ranitidine may be masked by gastric carcinoma. Before the course of treatment is necessary to eliminate a malignant tumor. With a sharp lifting of the drug is syndrome "ricochet ". Ranitidine may cause false positive reaction to determination of protein in urine. It is not recommended during treatment consume foods and drinks that irritate the mucous membrane of the stomach wall. Reduces the rate of reaction.

Drug Interactions:

Ranitidine increases metoprolol   and the AUC in the blood, reduces the absorbability ketoconazole . itraconazole . The drug has an inhibitory effect on hepatic metabolism aminophenazone, phenazone, lidocaine, diazepam, propranolol , Geksobarbitola, aminophylline, theophylline , Phenytoin, buformin, glipizide, indirect anticoagulants, BCCI, metronidazole . Ranitidine compatible with dextrose, NaCl, sodium hydrogen carbonate. Sucralfate, antacids   reduce the absorption rate of the drug (recommended between doses withstand at least 2 hours). Drugs that suppress bone marrow function, increased risk of neutropenia. When smoking decreases the effectiveness of Ranitidine.