Description overdue on 10/21/2013

Intestinal anti-inflammatory, antimicrobial agent . The main component - mesalazine.   Due to the synthesis of leukotrienes (lipid substances), prostaglandins and lipoxygenase activity reduction is achieved by anti-inflammatory effects of neutrophils. The active substance reduces the production immunoglobulins   lymphocytes, inhibits phagocytosis, degranulation and neutrophil migration. For most cocci bacteria and E. coli   It manifests antibacterial activity in the lumen of the large intestine. Mesalazin able to bind to oxygen radicals (free form), followed by their destruction, providing antioxidant effect . The drug reduces the frequency of relapses in patients with Crohn's disease, ileitis. Buy Salofalk can be in the form of rectal suppositories, tablets (prolonged form, coated with a special enteric-coated), suspensions.

Indications:

Salofalk prescribed for Crohn's disease . Mesalazin actively used in the ulcerative colitis   (non-specific form). The drug administered in the acute phase of the disease, as well as for prevention.

Contraindications:

The drug is not prescribed for hemorrhagic diathesis , Blood diseases, breast-feeding. Instructions for use Salofalk is not recommended to prescribe the drug for children until 2 years of age, as well as patients with ulcerative lesions of the digestive system. In the last month of gestation pregnancy, renal disease and liver of mesalazine administered with caution when evaluating long-term consequences. With a lack of glucose-6-phosphate dehydrogenase Salofalk tablets are not prescribed.

Side effect:

Bodies of blood:   reducing the number of agranulocytes , Anemia (megablastnaya, hemolytic, aplastic), eosinophilia, gipoprotrombinemii , Thrombocytopenia. The digestive tract:   epigastric pain, heartburn . vomiting . dry mouth . pancreatitis . hepatitis . stomatitis . appetite disorders . increase in liver enzyme system . Cardiovascular system:   chest pain, heart palpitations, shortness of breath on exertion, unstable blood pressure levels. Nervous system:   depressed mood, tremor of limbs, dizziness, headaches, polyneuropathy , noise in ears. Urogenital:   crystalluria, hematuria, oliguria, nephrotic syndrome , Anuria, proteinuria. Salofalk 500 can cause bronchospasm Itching, psevdoeritromatoz, mumps, dermatitis, alopecia, a significant quantitative decrease in production of the tear fluid, oligospermia , Skin rash, lupus syndrome, photosensitivity, general weakness. Reviews of preparation salofalk demonstrate its good tolerability.

Overdose:

Symptomatically manifested increased sleepiness, weakness, nausea, stomachalgia , Vomiting. It is recommended gastric lavage, the timely application of sorbents (activated charcoal), holding posindromnoy therapy.

Mode of application:

The dosage form of the preparation is selected depending on the level of intestinal lesions. In diseases of the distal portions ( proctosigmoiditis   and proctitis) designate candles salofalk; in advanced disease - mesalazine tablet form. Prevention of exacerbations of ulcerative colitis   (for non-specific): three times a day, 400-500 mg. Prevention of relapse of Crohn's disease:   1000 mg four times a day. Children from two years the number of mesalazine is calculated individually according to the scheme: 20-30mg / kg / day. In acute pathology   Salofalk granules are administered three times a day for 400-800 mg, the duration of treatment - 8-12 weeks. In severe   basic disease amount of medication may be increased to 3-4 grams (treatment at high doses should last no longer than 3 months). Mesalazine tablets taken after meals (it is recommended to wash down with water). The suspension is administered rectally at bedtime in the form Drug microclysters   After cleaning the lumen of the large intestine. Candles are administered three times a day at 500 mg. The calculation of doses for children with acute disease - 40-60 mg / kg / day; prevention - 20-30 mg / kg / day.

Special instructions:

The price of the drug Salofalk   - 500-600 rubles . It is recommended that regular blood tests (before, during and after treatment), urinalysis, control of the functional state of the renal system. There is an increasing severity of side effects in patients who advocate " slow acetylators ". Patients should be warned about the possibility of staining the tear fluid and urine reddish hue in some cases the tinting of contact lenses during prolonged wearing. If you forget to take a dose of it as soon as possible or in conjunction with the next dose. When skipping several consecutive doses is recommended to see a doctor without stopping therapy. When forming intolerance syndrome Salofalk   cancel.

Drug Interactions:

Mesalazine decreases the rate of absorption of cyanocobalamin. Salofalk improves secretion of calcium blockers and other urikozuricheskih funds. Salofalk increases the severity of toxic effects Methotrexate , Enhances hypoglycemic effect of sulfonylurea derivatives. Salofalk reduces the effect of spironolactone, furosemide , Rifampin, sulfonamides. When concurrent therapy there is a growing ulcerogenicity glucocorticosteroids .