Description overdue on 30-04-2012

Myotropic antispasmodic . In comparison with papaverine has a more pronounced and prolonged action, despite the similarity of the pharmacological properties and chemical structure. The mechanism of action is aimed at reducing the calcium influx into the smooth muscle tissue. Drotaverine hydrochloride dilates blood vessels, lowers peristalsis , The tone of smooth muscles of internal organs. The drug does not affect the autonomic nervous system, does not pass through blood-brain barrier . The drug is prescribed if it is impossible to use the m-holinoblokatory. When intravenously effect develops after 4 minutes, the maximum recorded in half an hour. Drotaverine produced in the form of solution, capsule, tablet.

Indications:

Drotaverine hydrochloride is indicated for the prevention and treatment of biliary dyskinesia, biliary colic , Smooth muscle spasm, dyskinesia of the gallbladder , Cholecystitis, pielita, postcholecystectomy syndrome, intestinal colic, pilospazma, proctitis, spastic colitis, spastic constipation , Gastroduodenitis. The drug is prescribed for vasospasm, endarteritis, postpartum struggles, in lingering disclosure throat, pharynx spasm during delivery, with threatened miscarriage, algodismenoree , During holetsistografii.

Contraindications:

Drotaverine is not prescribed for atrioventricular block, hypertension, cardiogenic shock, renal insufficiency, hepatic systems. During pregnancy, angle-closure glaucoma, atherosclerosis total, breastfeeding, prostatic hyperplasia prescribed after consulting experts.

Side effect:

Drotaverine can cause a sensation of heat, palpitations, dizziness, drop in blood pressure, increased sweating, and allergic reactions. When intravenously can develop an arrhythmia, atrioventricular block, collapse, respiratory depression.

Overdose:

Manifest violation atrioventricular conduction , Respiratory paralysis, heart failure, decrease of excitability of cardiac muscle.

Mode of application:

Drotaverine adults appoint three times a day by 40-80 mg inside. Subcutaneously and intravenously administered 1-3 times per day 40-80 mg. With a view to the relief of renal, hepatic colic administered intravenously 40-80 mg slowly. Acceptable intra-arterial injection in the peripheral vascular spasm. Children up to the age of six can be administered once 10-20 mg per day of not more than 120 mg.

Special instructions:

Drotaverine combine together with the anti-ulcer agents in the treatment of peptic ulcer   digestive tract. Therapy involves refusal to perform complex activities, driving a car.

Drug Interactions:

Drotaverine is able to weaken the action antiparkinsonian   (e.g., levodopa). The medicament amplifies the the effectiveness of spazmolitikov, bendazol, of papaverine. At the same time taking procainamide, tricyclic antidepressants , Quinidine is registered drop in blood pressure. Drotaverine reduces the spasmogenic effect of of morphine. Phenobarbital increases the effects of the drug Drotaverine.