Description overdue on 12/16/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

One vial contains 1 ml of solution platifillina gidrotartrata   (2 mg) and Distilled water . Pharmacopeia (a set of medical standards) specifies that the prescription for Latin formulated as: Platyphyllini hydrotartras solution pro injectionibus 0, 2%.

Product form

A solution for subcutaneous administration in the form injection   packaged:

• 10 ampoules in a cardboard box;
• 5 ampoules per pack Valium planimetric (2) in a cardboard box.

Pharmacological action

M-holinoliticheskoe . vazodilatirtee (vasodilator) and soothing action.

Pharmacodynamics and pharmacokinetics

Platifillin gidrotartrata characterized cholinolytic action: blocking M-choline receptor , Makes them insensitive acetylcholine form. With direct myotropic antispasmodic action on smooth muscles bowel . biliary tract . bronchi and eye   considered by the mechanism papaverinopodobnym . In addition, a weakly expressed a direct inhibitory effect on smooth. muscle vessels Calming effect CNS Especially on vasomotor center By providing a vasodilator and hypotensive effects.

Platifillin tartrate is well absorbed from the subcutaneous layer epidermis . However, administration of large doses it causes cumulation in the tissues of the CNS in significant concentrations. Derived by urinary and digestive systems.

Indications

Apply with functional disorders digestive , Including the smooth muscle spasm ulcers of the stomach and duodenum . colic (intestinal, liver and kidney). Furthermore, the agent is effective for diseases such as cholecystitis . bronchial asthma , and hypertension or angina . bradycardia from arrhythmia , Cerebral vasospasm, diarrhea , Pain in the pancreatitis . biliary dyskinesia , Inflammation of the esophagus. Poisoning these substances and how acetone . boric acid , Strong acid, arsenic . reserpine . The diagnostic (fundus study and definition of refraction of the eye) and the treatment of ophthalmology ( keratitis . iritis . iridocyclitis Various eye injury) is used for the expansion of the pupil.

Contraindications

Not recommended for use in glaucoma , Varying degrees of failure, liver or kidney function, ulcerative colitis . myasthenia . paralytic ileus   or atony bowel . Hypersensitivity to the components of the drug.

Side effects

Most have the following side effects of high-dose dry mouth, dilated pupils, intestinal,   decrease in blood pressure, or tachycardia , Violation accommodation . dizziness . breathlessness , Acute urinary retention, headache , Excitation and CNS convulsions .

Instructions for use (method and dosage)

Administered orally, parenterally ( subcutaneously . intravenously ) rectally or topically . Platifillin gidrotartrata intramuscularly used when necessary - is appointed and is adjusted by the attending physician, who is responsible for the appointment. Dose is determined depending on the symptoms and severity of the disease, the route of administration and the age of the patient. Platifillin gidrotartrata usually prescribed for the treatment of:

• Relief of acute ulcer pain, intestinal, liver or kidney colic , Prolonged bouts of asthma, cerebral and peripheral angiospasm adults - 1-2 ml of 1 or 2 times per day.
• As an antispasmodic adults - 1 ml every day for one month. The maximum single dose is one for an adult subcutaneously - 10 mg per day of not more than 30 mg.

Overdose

The clinical picture of an overdose platifillin hydrogen tartrate:

• dry mouth;
• increase in heart rate and blood pressure reduction;
• dilated pupils and a lack of response to light;
• paresis accommodation ;
• acute difficulty urinating;
• enteroplegia ;
• convulsions ;
• shortness of breath;
• hyperthermia and redness of the skin;
• excitation of the central nervous system with its subsequent oppression;
• various disorders of consciousness, including hallucinations ;
• respiratory failure.

Ongoing activities in this case: forced diuresis The use of inhibitors of the enzyme - cholinesterase (for example, physostigmine . galantamine or neostigmine methylsulfate ) To relieve and reduce intestinal paresis tachycardia . If the excitation of the central nervous system mild and seizures are not expressed, it is recommended to use magnesium sulfate In severe conditions - sodium hydroxybutyrate . oxygen therapy To conduct ventilatory .

Cooperation

Platifillin tartrate is able to:

• Extend hypnotic effect phenobarbital . etaminal sodium . Magnesium sulfate .
• Block Neostigmine methylsulfate .
• To enhance the effect of H2 histamine blockers . Digoxin and riboflavin .
• Amplify mydriasis from adrenomimetikami and nitrates Increasing intraocular pressure.
• Compatible with caffeine vascular spasm in the brain.
• Compatible with kordiamin and diafillinom .
• FROM morphine eliminates bradycardia , Nausea, vomiting.
• FROM Verapamil eliminates bradycardia .

Terms of sale

Prescription.

Storage conditions

In the dark and reach of children.

Shelf life

Five years.

Analogs

• Platifillin-Health
• Infacol
• Enterospazmil

Reviews platifillin gidrotartrata

Numerous reviews of the drug talk about its effectiveness and accessibility, but many are interested in the complexity of the application in terms of interaction with other drugs, the mode of administration and dosage. All this should be strictly controlled and adjusted by the attending physician who wrote the prescription.

Price, where to buy

10 vials platifillin gidrotartrata can buy almost any drug store at a price of 45-70 rubles.