Description overdue on 12/16/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications platifillin
• Contraindications
• Side effects
• Instructions for use platifillin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Babies
• During pregnancy (and lactation)
• Analogs
• Reviews
• Price, where to buy

Composition

In one ampoule are 1 ml of a transparent colorless solution to be injection . platifillina gidrotartrata   (2 mg). As auxiliary substances - distilled water   injection.

One tablet contains platifillina gidrotartrata   weight on the 0, 005 grams plus papaverine hydrochloride 0, 02 g, in the list of excipients included: potato starch . calcium stearate . sugar . talc .

Product form

The carton 5, 10 vials.

Combined vehicle with papaverine is available as white tablets - 10 pieces. in the contour cellular packaging.

Pharmacological action

The drug has sedative . antispasmodic . vazodilatirtee ( vasodilator ) Action.

Pharmacodynamics and pharmacokinetics

Rlatyphylline - An international name (INN), which was adopted for consumption in the United Kingdom (BAN). Platifillin represents pyrrolizidine alkaloid Contained in the plant genus groundsel ( Senécio ). The active ingredient of the drug is used in the form of gidrotartrata Recipe in Latin on the substance Platyphyllini hydrotartratis Capable of oppressing cholinergic system Which transmits excitation from parasympathetic nerves   on implementing bodies Thereby exerting a calming effect on vasomotor center Significantly weaker blocks N-cholinergic receptors autonomic ganglia .

The drug has anticholinergic a dose-dependent effect, ie lower doses inhibit secretion Salivary and bronchial glands . sweating . accommodation of eyes, causing expansion pupils Increase Heart Rate , While high doses decrease the contractile activity esophagus , including Biliary and gall Moreover - urinary tract, and inhibits gastric secretion.

With regard to the pharmacokinetics, the platifillin can easily pass through gistogematicalkie barriers Including and blood brain , Cellular and synaptic membrane . The correct dosage and intervals of administration does not cry cumulation preparation, however, administration of high doses causes its accumulation in tissues CNS in tangible concentrations. Metabolised at liver and eliminated at kidney and intestine .

Indications platifillin

Use spasm smooth muscles of internal organs   ( pilorospazm , Intestinal, renal colic or biliary colic) in diseases such as gastric ulcer and duodenum . cholecystitis or cholelithiasis , Acute pancreatitis and other chronic, bronchial asthma   or laryngism And arterial hypertension . angina . spasm of cerebral arteries   and angiotrofonevrozah in combination therapy.

For diagnostic purposes Platifillin used for mydriasis Including - study fundus , Determining the manifest refraction, acute inflammatory diseases of the eye, for example, inflammation iris . keratitis or eye injury.

Contraindications

Prohibited use in glaucoma . coronary heart disease . thyrotoxicosis , Heart, liver or kidney failure, as well as the presence of hypersensitivity to platifillin.

Side effects

Dry mouth and thirst, difficulty urinating, or urinary retention, paresis of accommodation (ciliary muscle of the eye), the excitation of the central nervous system, dizziness , Dilated pupils, headache . convulsions . photophobia . acute psychosis And with the circulatory system - tachycardia . Among other things: pulmonary atelectasis .

The probability of occurrence of adverse reactions increases when high doses platifillin.

Instructions for use platifillin (method and dosage)

Apply necessary parenterally ( subcutaneously . intramuscularly ) rectally , In addition to Ophthalmology - topically .

Injections platifillin, instructions for use

Apply 2-4 mg three times a day. The maximum allowable single dose of not more than 10 mg, whereas the daily - 30 mg. Dose is determined depending on the indication, the mode of administration and the age of the patient. Platifillin at pancreatitis   administered subcutaneously 1-2 ml for 12 hours in a period of intense pain to reduce the spasm of smooth muscles of the prostate.

Tablets Platifillin, instructions for use

Ingest 1 tablet 2 or 3 times a day.

Overdose

Pseudoileus , Urinary retention, paralysis of accommodation, increased intraocular pressure, dryness of the mouth, nose, and throat that may cause difficulty in swallowing act mydriasis to the disappearance of the iris completely, tremor . convulsions . hyperthermia , Central nervous system excitation followed by depression her, as well as respiratory and vasomotor centers.

As treatment is applied forced diuresis Administered inhibitors holistenazy, such as Physostigmine . Galantamine or Neostigmine methylsulfate That can weaken and reduce intestinal paresis tachycardia. In cases of moderate excitement and convulsions weak force is best to enter magnesium sulfate However, in severe cases - sodium hydroxybutyrate To conduct oxygen therapy and Art, ventilation . If tachycardia is threatening the patient's life, then apply quinidine sulfate . Propranolol .

Cooperation

Indications platifillin should take into account the presence of other diseases that require regular use of other medical devices. In an application with the following substances can occur such reactions:

• Haloperidol - In patients with schizophrenia may be reduced antipsychotic effect.
• Neostigmine methylsulfate - Platifillin is his antagonist.
• Phenobarbital . etaminal sodium . Magnesium sulfate   - An increase in the duration of hypnotic action.
• Others Mr. holinoblokatory   and drugs with m-anticholinergic activity (e.g. Amantadine . Phenothiazine Tricyclic antidepressants Some antihistamines drugs) - increased likelihood of adverse reactions.
• Morphine - Increased inhibitory effect platifillin on the cardiovascular system.
• MAO inhibitors - positive chronotropic (increased heart rate), and bathmotropic the effect (increase in the excitability of the heart).
• Cardiac glycosides   - Positive bathmotropic effect.
• Analgesics , Sedatives and anxiolytics able to enhance the action platifillin for pain, resulting in smooth muscle spasm.
• Antihypertensive / sedatives platifillin agents enhance the effect of vascular spasm.

Terms of sale

The solution and tablets platifillin platifillin with papaverine prescription.

Storage conditions

In sheltered from the rays of light place, preferably in a tightly sealed original packaging at a temperature not exceeding 30 ° C.

Shelf life

The vials may be stored in the sealed package five tablets - three years.

Cautions

It is recommended to avoid hazardous activities such as driving and control other machines that require high speed of psychomotor reactions and attention.

Babies

It is recommended to be used with caution, if at children chronic lung disease As well as a reduction in the secretion of bronchial secretions can cause condensation and the formation of traffic jams in the bronchi. At risk children with brain injury (drug can amplify the effects of the disease), in addition to Down syndrome (there is a possibility unusual dilated pupils and increase in heart rate) cerebral palsy   (more pronounced reaction to the anticholinergic effect). Not recommended injections platifillin children under 15 years.

During pregnancy and lactation

Information on safe use of platifillin during pregnancy or lactation (breastfeeding) is no longer present. Please note that the expected benefit to the mother must substantially exceed the possible risks to the fetus or child.

Analogs

• Meteospazmil
• Vinboron
• Infacol

Reviews platifillin

Reviews prove an effective tool, but application requires great care, because Platifillin effect on smooth muscle tension and relaxation which a man can not control - only to feel the effects of its atony or increase tone. It should be supervising competent professional who can properly regulate the intervention in this area without causing great harm.

Price platifillin where to buy

Price vials (10 pieces in a box) by an average of 50 rubles., The price of tablets with papaverine Platifillin slightly higher - 140-180 rub. (pack contains 10 tablets).