Description overdue on 15/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use of rabeprazole (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The chemical composition of a single enteric capsule contains 10 mg of rabeprazole. actively acting drug compound rabeprazole sodium .

Product form

Enteric capsules (10 mg.), Whose number in a single package can vary from 5 to 60 pieces.

Pharmacological action

This drug belongs to the group   anti-ulcer drugs So-called inhibitors of H + -K + -ATPase.

Pharmacodynamics and pharmacokinetics

This drug has an effect on the enzyme H + -K + -ATPase,   which is produced in gastric parietal cells Acting as proton pump inhibitor . As a result, the active drug compound actively blocks the formation of hydrochloric acid   at the final stage and also reduces the incentives secretion   irrespective of stimulus.

After taking the drug at a dosage of 20 mg. complete resorption occurs in about 3, 5 hours. It is noteworthy that bioavailability   active active drug compound, and absorption properties of the drug itself does not depend on the time of its reception.

Indications

The drug used in the treatment of:

• duodenal ulcer , Including at the acute stage of the disease;
• pathologic hypersecretion ;
• gastroesophageal reflux disease ;
• stomach ulcers ;
• Zollinger-Ellison ;
• gastritis   ( Helicobacter pylori eradication ), Including chronic (with antibacterial drugs );
• relapse peptic ulcers Induced   Helicobacter pylori .

Contraindications

Absolute contraindications drug considered pregnancy and lactation, hypersensitivity to the drug, as a rule, to rabeprazole or substituted benzimidazole .

Side effects

In applying the drug from Gastrointestinal, respiratory and nervous system , and musculoskeletal system may experience the following side effects:

• diarrhea, loss of appetite, stomatitis, vomiting, nausea, constipation, dryness of the oral mucosa, increase in liver transaminases, flatulence;
• dizziness, fatigue, drowsiness, blurred vision and taste receptors, headache,
    leukopenia and thrombocytopenia;
• cramps, myalgia, arthralgia;
• sinusitis, pharyngitis, cough and rhinitis;
• back pain;
• fever;
• allergic reactions such as rash.

Instructions for use of rabeprazole (method and dosage)

Capsules containing drug substance is taken orally. Dosing regimen, as well as its dosage depends primarily on the type and severity of the disease, and the condition of patients. The recommended initial dosage of medication - 10-20 mg.

Overdose

At the present time it was not published scientific data confirmed the impact of a drug overdose.

Cooperation

Activity Action drug compound   rabeprazole,   contained in the chemical composition of the drug does not interact with antacids . However, the substance can affect the concentration plasma ketoconazole , and digoxin.

To use the drug may be in conjunction with Diazepam, warfarin, theophylline,   and, moreover, Phenytoin . In the case of medically necessary drug can be administered simultaneously with drug-like inhibitor of the proton pump Pantoprazole.

Terms of sale

Leave a prescription.

Storage conditions

The drug should be stored out of reach of children.

Shelf life

2 years.

Cautions

Before therapeutic treatment rabeprazole must first eliminate the presence of patients malignant tumors in the digestive tract Because the use of the drug may mask the symptoms and complicate timely diagnosis oncological diseases .

Precautions should be used drug in the presence of impaired liver function. When using this drug, as well as Digoxin and ketoconazole dosage should be adjusted last two drugs.

If any such side-effects as   drowsiness and fatigue   is to abandon control of the vehicle or to perform work that requires high concentration of attention.

Analogs of rabeprazole

Among the main counterparts of rabeprazole are the following drugs:

• Zolispan;
• Ontaym;
• Noflyuks;
• Zulbeks;
• Rabelok;
• Hayrabezol;
• Omeprazole;
• Vero rabeprazole;
• Rabeprazole-OBL.

It should be noted that the price analogues rabeprazole average exceeds the cost of the drug twice.

Differences between rabeprazole and omeprazole

Although these two drugs are similar in their chemical composition and is used in the treatment of similar diseases, according to experts, in some cases, for example, gastroesophageal reflux disease such as the medicine rabeprazole more effectively treats the symptoms and accelerates the recovery of normal operation esophagus.

Synonyms

Rabeprazole sodium.

Babies

Not recommended, since there is no clinical experience with the drug in the treatment of children.

During pregnancy (and lactation)

During the research it was proved that the current active compound contained in the chemical composition of the drug, though in small quantities, but nevertheless overcomes placenta in the womb. For this reason, it does not take into rabeprazole time pregnancy And, moreover, during breast feeding.

Reviews of rabeprazole

The positive feedback on rabeprazole patients often note the budgetary cost of the drug, and the negative aspects include the presence of many side effects.

Price rabeprazole, where to buy

Price rabeprazole depends on the form of the drug and the region.

Buy in Moscow rabeprazole (packaging, 2 blisters, capsules 20 mg.) Can be an average of 200 rubles.