Description overdue on 17-04-2012

Antiestragen . The mechanism of action is based on the specific binding receptors of the pituitary gland and the ovaries of estrogen receptors. At a high content of estrogen drug has antiestrogenic influence At low levels of estrogen appears Moderate estrogenic effect . Small doses of the drug Clomiphene increase the production of LH, FSH, prolactin and other gonadotropins increases Ovulation . Large dosages of the drug inhibit the production of gonadotropin-releasing hormone. Clomiphene does not possess androgen and progestin activity. Available in tablet form.

Indications:

Clomiphene is prescribed for dysfunctional metrorrhagia , Polycystic ovary syndrome, secondary amenorrhea , Galaktoree, postkontratseptivnoy amenorrhea, Stein-Leventhal syndrome, Chiari syndrome-Frommelya. The drug is indicated for the induction of ovulation in anovulatory infertility For diagnostic purposes in violation of the pituitary (gonadotropin-releasing function).

Contraindications:

Clomiphene is not prescribed for metrorrhagia of unknown origin, tumors of the genital organs, pregnancy, ovarian failure on the background hyperprolactinemia , Endometriosis, hypofunction of the pituitary gland, pituitary tumors when diagnosed ovarian cysts , Hypersensitive to the active ingredients in the pathology in the kidney, liver systems.

Side effect:

The digestive tract:   diarrhea, flatulence, stomachalgia , Vomiting, nausea, dyspepsia. Nervous system:   somnolence, insomnia, irritability, dizziness, headaches, slowing of motor activity, reduction in the rate of mental reactions. Urogenital:   increasing the size of the ovaries, menorrhagia, dysmenorrhea , Abdominal pain, polyuria . frequent urination . Allergic reactions, alopecia, weight gain, blurred vision, painful breast.

Overdose:

Manifest violation of visual perception, "tides" of blood to the face, nausea, vomiting, neurological symptoms. Requires removal of the drug, these symptoms disappear on their own.

Mode of application:

Stimulation of ovulation: before going to bed every day, taking 50 mg clomiphene for five days, starting from the fifth day of the menstrual cycle. In the absence of menstruation drug taking at any time. If ovulation does not develop during the month, then the dosage was increased to 150 mg per day or increase the duration of treatment is 10 days. Maximum course dose - 1 gram. Ovulation is diagnosed by the average, the cyclical increase in the production of LH, the presence of a biphasic basal body temperature, increase in serum progesterone. If pregnancy does not occur when diagnosed with ovulation, then the drug Clomiphene repeat scheme. If diagnosed after ovulation did not come menstruation, the doctor rule out / confirm the pregnancy. Persons male Clomiphene prescribed for 3-4 months, 1-2 times a day for 50 mg. It is recommended that systematic evaluation of semen.

Special instructions:

Clomiphene increases the likelihood of multiple pregnancy . Efficacy depends on the level of endogenous estrogen (at a low concentration of pituitary gonadotropins practically ineffective, with sufficient concentrations of endogenous estrogen efficiency high). During treatment requires regular monitoring gynecologist, evaluation of the phenomenon of "pupil", control over the work of the ovaries, evaluation of vaginal examination. Clomiphene affect the control of vehicles.

Drug Interactions:

Clomiphene is fully compatible with drugs gonadotropins.