Description overdue on 04/09/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use Gonal-F
• Contraindications
• Side effects
• Instructions on Gonal-F (Method and Dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

The preparation contains the active substance in an amount of 11 micrograms follitropin alfa   or 150 IU.

Also present in the composition of various auxiliary components: sucrose, sodium hydroxide, sodium dihydrogen phosphate monohydrate, methionine, phosphoric acid and polysorbate 20, sodium dihydrogen phosphate dihydrate.

The solvent used is 1 ml. water d / and.

Product form

Formulation Gonal F is produced in the form of white lyophilisate for the preparation of a solution intended for subcutaneous administration. Method of production of a solution for subcutaneous injection may be as follows: 22 mkg / 0, 5 ml, 33 g / 0, 75 ml, 66 g / 1, 5 ml, respectively. Thus, in 0 5 mL contain 22 mg of active substance equivalent of 300 IU to 0, 75 ml containing 33 mg of active substance equivalent of 450 IU, 1, 5 mL contain 66 mg, equivalent to 900 IU, packed in shprits- handle. Furthermore, in the packaging of disposable needles are placed in a plastic container and a sticker to mark the special of the day of the first administration.

Pharmacological action

Gonal-F has the effect of stimulating the growth and development of follicles.

Pharmacodynamics and pharmacokinetics

Follitropin alfa   It is recombinant human follicle stimulating hormone, which is produced by genetic engineering techniques based on the culture of hamster ovary cells.

Use of Gonal-F has gonadotrophic action and estrogenic effect, thus stimulating the proliferation of the endometrium and promoting ovulation suffering suppressed endogenous production of gonadotropin, and fully stimulate the growth and maturation of ovarian follicles, favoring the development of multiple follicles during ovarian hyperstimulation programs for different reproductive assistive technologies. As a result of subcutaneous injection quantity absolute bioavailability it is usually about 70%. Distribution follitropin alfa   It occurs in the extracellular fluids. Repeated administration of Gonal-F leads to the accumulation of the active substance for 3-4 days, with marked excess of the equilibrium concentration of almost 3 times. Excreted drug excreted in the urine.

Indications for use Gonal-F

The main indications for use of the drug are:

• anovulation , including polycystic ovary syndrome When therapy Clomiphene ineffective;
• Ovarian stimulation in women, accompanied by severe deficiency of FSH and LH in combination therapy;
• Controlled Ovarian hyperstimulation , ART programs;
• stimulation spermatogenesis   men with hypogonadotropic hypogonadism In combination therapy with hCG.

Contraindications

Not recommended Gonal-F in the presence of:

• hypersensitivity to the drug or its subsidiary components;
• hypothalamic-pituitary tumors ;
• bulky tumors or ovarian cysts Not due polycystic ovary syndrome ;
• lactation, pregnancy;
• uterine bleeding   of unknown etiology;
• ovarian cancer . uterus   and Breast .

Also, the drug is not prescribed, if you get a positive effect is almost impossible, namely, in pathologies of the genital organs, uterine fibroids That are not compatible with pregnancy, premature menopause, and primary ovarian insufficiency. Men are not assigned to a drug if there is a primary testicular failure .

Side effects

It was found that the use of Gonal-F in patients of either sex may be associated with a variety of adverse symptoms affecting various systems and organs.

In the treatment of women often headache . pain . discomfort and   heaviness in the stomach . nausea . vomiting   and diarrhea . It is also possible the development of disorders in the activity of the reproductive system and mammary glands, for example, ovarian cysts . Noted some anomalies in the immune, circulatory and respiratory systems.

Application men often causes abnormalities in the reproductive system and mammary glands - gynecomastia, varicocele .

Many are concerned about the appearance of acne Problems with the operation of the immune and respiratory systems. All patients, regardless of sex, local reactions may develop, for example, soreness .   puffiness , Redness and bruising. Often there is an increase in body weight and other violations.

Instructions on Gonal-F (Method and Dosage)

Treatment with this drug should be carried out under the supervision of a specialist who has extensive experience in therapy infertility . Gonal-F is intended for subcutaneous administration. At the same time each day is recommended to change the injection site. The first injection should be administered an expert, and then perhaps a separate application after the training and the availability of opportunities for timely medical advice.

In addition to the features of use will be found video instruction on the use of Gonal-F :

To recommend women to begin treatment in the first 7 days of the cycle. This stimulation Gonalom-F is performed under ultrasound of the ovaries, that is measured by the size of the follicles and the concentration of estrogen. Typically, therapy is started with a daily dose of 75-150 IU, increasing by 37, 5-75 IU after 7-14 days to obtain an adequate, but not excessive response.

The daily maximum dose should not exceed 225 IU. It is believed that positive changes occur within 4 weeks, otherwise, treatment is discontinued. Next stimulation starts at a higher dose. In any case, the dosage and dosage schedule for both women and men, depending on the diagnosed problem, by a doctor.

Overdose

In clinical cases of overdose associated application Gonal-F is not set.

Cooperation

It is known that the simultaneous use of Gonal-F and other stimulating agents, e.g.,   hCG, clomiphene Can significantly enhance the response of the ovaries. A background on the desensitization of pituitary GnRH agonist or antagonist, on the contrary, reduced. Therefore usually require higher doses of Gonal-F.

The interaction of this drug with other drugs does not have a particularly significant effect on the body.

Terms of sale

Pharmacies Gonal-F can be purchased with a prescription.

Storage conditions

For storage of the drug is required, protected from light and children, at a temperature of 2-8 C. Avoid freezing stimulant.

Shelf life

2 years.

Analogs of Gonal-F

The main counterparts of the drug are - Follitrop   and Follitropin alfa.

Alcohol and Gonal-F

It should be noted that the absolute contraindications to the simultaneous use of the drug and alcohol use is not. However, throughout the procedure to refrain from abuse of alcohol beverages, especially if it is strong alcohol.

Reviews of Gonal-F

Generally, reviews of Gonal-F found on various forums devoted to children and maternity. Many women report that deal with infertility for several years, and now they just have one hope for IVF.

Most users report that follicular growth occurs in the first cycle, but fertilization does not always happen. Women often report that a noticeable effect is seen only during the next cycle. Thus Reviews 75ME Gonal-F shows that at a time the drug was used in this dosage.

Stimulation Gonalom-F is carried out in several stages with different doses. The average clinical scores indicate that enough 2-3 courses. For many stimulation Gonalom-F, who became pregnant or planning to become pregnant in this way, it is considered quite normal and quite comfortable. As you know, most women are willing to try different methods of infertility treatment, and reviews of stimulation Gonalom-F show that it is one of the most effective ways.

Price Gonal-F, where to buy

This drug can be purchased in almost any pharmacy in the presence of a prescription. Therefore, to buy in Moscow can be over 990-17500 rubles, depending on the number of doses needed. Price Gonal-F 75 IU varies between 4900-8340 rubles, and the price of Gonal-F 900 IU is 14460-17054 rubles.