Description overdue on 06.10.2011

The main active ingredient is the current levonorgestrel . Is an emergency contraceptive: 1 tablet is taken within 72 hours-uh. After intercourse (unprotected), take a second pill 12 hours. The drug has a triple mechanism of action:

1. Levonorgestrel   delays or stops Ovulation , Whereby the egg is not released in the oviduct of the ovary.

2. Postinor prevents fertilization by sperm.

3. The drug alters the usual structure of the inner wall of the uterus (endometrium), preventing the attachment of a fertilized egg. In case, if conceiving   happened, PM has abortifacient effect, implanting the fertilized egg.

After receiving the first levonorgestrel tablets maximum concentration is 1 to 6 hours
Postinor is hydrolyzed in the liver metabolites of the drug is excreted as glucuronides. Metabolites not exert pharmacological effects. The effectiveness of the contraceptive action of drugs decreases with the passage of time that has elapsed between sexual intercourse and levonorgestrel. Upon receipt within 24 hours at 95% efficiency. Under the recommended dosages of the drug has no significant effect on the metabolism of carbohydrates, fats and coagulation factors .

Dosage Form:

Tablets (in the package - 2 pcs.)

Indications:

Emergency method of contraception after sexual intercourse. The drug is taken after the rupture, slippage, misuse Condom , Unsuccessful completion of the interrupted sexual intercourse, shear rupture, premature removal of the cervical plate or aperture ( pessary ), Under the mistaken calculating the days ovulation at application of the calendar method of contraception, at loss of either you delete a contraceptive intrauterine means of, when skipping of three and more of contraceptive tablets with regular admission oral contraceptives . Rape.

Contraindications:

Pronounced liver disease, pregnancy, a history of thromboembolism, arterial thrombosis, venous, uterine bleeding ( metrorragii ). Relative contraindication acts puberty.
Not suitable for children under 16 years.

Side effect:

Side effects of Postinor with the endocrine system: delayed menstruation, tension in the breasts, dysmenorrhea . GIT: dyspepsia. Dizziness, fatigue.

Mode of application:

Postinor accept inside, washed down with the necessary quantity of of water in the of independence of from reception of of food. The tablet must be taken within 2 days, but not later than 72 hours after intercourse. After 12 hours, take another one tablet. For emergency contraception is recommended to use no more than 1 time in half a year.
If after taking the pill vomiting has occurred, it is necessary to repeat the drug. PM accept in any day menstrual cycle.

Overdose:

The drug in high doses does not cause serious consequences, manifested dyspeptic disorders. Treatment is symptomatic.

Special instructions:

Levonorgestrel is not recommended for women with menstrual irregularities. Within one month should not be taken more than once Postinor. Do not is used as a a regular, continuous of contraception because of decrease in of the effective action and amplification severity of side effects. The drug is not a substitute for regular contraception. Possible risk of uterine bleeding.

If the intake of drugs developed pregnancy or tablet has been taken against the background of an existing pregnancy, it should be borne in mind that the risk of negative effects on the fetus are not installed. The drug has no effect on the speed of psychomotor reactions. Consequences of Postinor dependent on compliance with the recommendations and dosage of the drug.

Drug Interactions:

Simultaneous treatment with hepatic enzyme inducers increases metabolism Postinor. Joint reception griseofulvin . tetracyclines . ampicillin , Barbitura, rifampicin , Primidone, ritonavir, phenytoin, rifabutin . carbamazepine   Postinor reduced contraceptive effect. Levonorgestrel amplifies toxicity   cyclosporine .