Description overdue on 07/08/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Ovestin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Part tablets Ovestin   part of the active substance theelol And auxiliary ingredients: amylopectin . potato starch . lactose monohydrate . povidone, magnesium . stearate . silica .

Part candles Ovestin   part of the active substance theelol , and witepsol S 58   as an optional ingredient.

Cream Ovestin   accommodates theelol As well as a number of additional ingredients: cetyl palmitate . octyldodecanol . cetyl alcohol . glycerol . polysorbate . stearyl alcohol . sorbitan stearate . chlorhexidine hydrochloride . lactic acid . sodium hydroxide . water .

Product form

Tablets Ovestin   are white, flat, round shape with beveled edge on one side surface marking " DG "Over the numeral" 8 'And break line on the other side of the tablet - marking " ORGANON * ".

Vaginal Cream   a homogeneous mass, shade pure white or whitish, has a specific smell.

Vaginal suppositories   can have color from white to cream, torpedo-shaped, uniform surface and a longitudinal section.

Pharmacological action

As part of the funds is a natural female hormone theelol . This so-called short-acting hormone. Consequently, it does not provide the stimulation of proliferative processes in endometrium . Tool speeds up the recovery process of mucosal epithelium of the vagina, as well as the optimization of pH environment and restore the natural vaginal flora. As a consequence, increases the level of local immunity , There is an obstacle to the development of pathological flora.

Pharmacodynamics and pharmacokinetics

The tool can be used in the presence of pathological symptoms that occur due to lack of estrogen in the body. It notes the particular efficacy in the treatment of disorders of the urogenital character.

If there are atrophic changes   vaginal mucosa, the drug contributes to the restoration of the mucosa.

As a consequence, under the influence of the drug increases the level of stability of vaginal tissues to inflammation and infection. The women say that after receiving funds decreased expression dryness and itching of the vagina . dyspareunia Infections of the genitourinary system, and disappear complaints are associated with the incontinence .

When administered intravaginally means optimal bioavailability of the active ingredient is provided in place of its action. Theelol by suction gets into the systemic circulation. As a result, significantly increases plasma concentration unconjugated estriol . The highest level of concentration in the blood plasma observed 1-2 hours after its administration. Approximately 90% estriol binds albumin in blood plasma.

Since estriol is the end product metabolism Mostly it is excreted in the urine in conjugated form. Since feces excreted allocated only a small part of the drug (about 2%), mainly in unconjugated form.

Indications

Indications candles Ovestin , and tablets   and cream   following:

• treatment atrophic vaginitis ;
• age-related changes in the vaginal mucosa of atrophic nature that arise as a result of estrogen deficiency;
• frequent urination , Pain when urinating;
• urinary incontinence ;
• infertility Which is associated with cervical factor;
• for diagnostic purposes, if the results of smear cytology unclear;
• preventive measures for the prevention of inflammation of the urogenital area;
• preventive measures for the prevention of complications after surgery with access through the vagina.

Contraindications

Contraindications to Candles . pills . Cream Ovestin   following:

• intolerance of components means;
• pregnancy;
• of breast cancer , Suspected cancer or breast cancer history;
• estrogen-dependent malignant tumor ;
• vaginal bleeding of unknown etiology;
• venous or arterial thromboembolism   history;
• porphyria ;
• acute liver disease or changes in liver function tests.

Side effects

Medicine in the form of suppository   can cause itching or irritation manifestation of a local nature. You may experience pain or tension of the mammary glands. These side effects are usually observed in the first days of use of the drug, but sometimes their development shows that assigned too high dose means.

It was also a manifestation of acyclic bleeding, metrorragii , Breakthrough bleeding.

In the annotation to the drug indicates that the treatment Ovestin may develop other side effects. Such forms will be provided with treatment Estrogen-progestogen But a sufficient amount of data is different in that there Ovestin not.

This is the benign and malignant tumors of estrogen, thrombosis , Heart attacks and myocardial infarction , Gallbladder disease, skin and subcutaneous inflammation, dementia .

Instructions for use Ovestin (method and dosage)

If in the course of treatment the patient is assigned Ovestin, instruction on the use of funds should be clearly performed.

The preparation may be used as cream . pills . Candles And thus, regardless of the route of administration, it is equally effective. When using any form of a preparation, whether tablet or ointment suppositories, it is taken once a day.

Instructions for use Ovestin crme   It suggests that the agent is administered before bedtime, with a special applicator. Initially use it every day, with marked improvement in the state can go to the regimen of twice a week. The duration of treatment depends on the disease.

Pills Usually prescribed in doses of 2-4 pc. (4-8 mg) per day for one month, then the dose is reduced to 1-2 tablets (1-2 mg) per day. If a person says incontinence may be assigned a higher dose of the drug.

Introduction suppository   1 is shown once a day, and gradually reduced when the symptoms, the introduction can proceed spark twice weekly.

Candles   administered once a day, in improving the symptoms of moving to more rare administration - 2 times a week.

If you are being prepared for surgery in the transvaginal access, one candle is introduced each day, treatment begins two weeks before the surgery. Further, since the manipulation is also introduced two candles per week for 14 days. The same pattern applies cream Ovestin.

If reception dose was missed, and wherein the interval between doses constituting no more than 36 hours, it is necessary to take a dose, which was omitted, and further to continue the treatment in the usual way. If the interval is greater than 36 hours, the reception continues Ovestin scheme.

Overdose

In overdose Ovestin may experience nausea and vomiting, and bleeding from the vagina.

In this case, symptomatic therapy is practiced.

Cooperation

There were no adverse interactions with other drugs.

However, it should be noted that the pharmacological properties Ovestin can define the interaction with anticonvulsant and anti-retroviral drugs, antibiotics As well as drugs, which is composed of tutsan .

There is evidence that estriol is able to enhance the effect of a number of corticosteroids and theophylline .

Terms of sale

Ovestin available on medical prescription.

Storage conditions

Pills   should be stored in a dark and dry place, the temperature should be between 2 to 30 ° C.

Candles   and cream   must be stored in a dark and dry place, the temperature should be between 2 to 25 ° C.

Shelf life

Ovestin Shelf life - 3 years.

Cautions

It is impossible for a long time to conduct therapy with high doses of drugs (no more than a few weeks).

If you need long-term treatment should conduct regular breast examinations and checkups at the gynecologist, careful monitoring koagullogrammy .

When treating postmenopausal symptoms   hormone replacement therapy is practiced only in case of pronounced symptoms that worsen the quality of life.

Women should be aware of what exactly the changes in the mammary glands, manifested in the course of treatment, you must tell the doctor.

When the manifestation of the factors that are contraindications to treatment, or other adverse changes in health status means necessary to stop treatment.

Since estrogen can cause fluid retention in the body, the health of people with heart failure and kidney disease need to be carefully monitored.

Analogs Ovestin

Analogs Ovestin in Russia - a drug Dimestrol . Gormopleks . Mikrofollin forte . Tefestrol . Their composition is also present estriol. However, patients should not be interested in the price counterparts, and the effectiveness of their impact on the body. Therefore, about what can be replaced Ovestin, you must be sure to consult with your doctor.

Babies

Ointment Ovestin for children is only used by the physician. The tool is sometimes used in synechias   children. With this diagnosis cream for children is used only by the scheme and to the dosage, which is designated by the doctor.

When pregnancy

During pregnancy, women are not appointed Ovestin.

Reviews Ovestin

Reviews candlelight Ovestin that women leave, going to the thematic forum, mostly positive. The positive impact of funds as a means of support during menopause. Also, patients leave reviews Ovestin cream and pills, noting that these drugs can reduce the intensity of unpleasant symptoms Menopause , Contribute to the treatment of some diseases. It is also noted that the ointment is easy to use. Reviews of doctors indicate that treatment Ovestin is mostly effective.

Less common responses about how to use the cream for children. Parents say that Ovestin for the treatment of children should be used strictly according to recommendations of your doctor. Sometimes women talk about the manifestation of the application of burning candles at first. However, this side effect quickly disappears.

Price Ovestin where to buy

Buy Tablets Ovestin   You can for the price of 800-900 rubles per 30 pieces. Cost candles Ovestin   an average of 1000 - 1100 rubles. Cost cream Ovestin   15g - 1100 1300 rubles.

In Ukraine, the price ointment Ovestin   is 260-270 hryvnia.