Description overdue on 22-04-2012

Estrogen drugs . The main component is Estradiol It is identical to the hormone, which vyrabaetsya ovaries in women from the first day of the menstrual cycle and up Menopause . Proginova has feminizing effects, stimulates the development of the vagina, uterus, fallopian tubes, ducts and stroma of the mammary glands, growth and closure of the epiphysis of long bones zone, formation of female secondary sex characteristics. The medicament has procoagulant effect It reduces antithrombin preparation 3. antiatherosclerotic effects, lowers cholesterol levels in the blood. Proginova produced in the form of gel, spray, solution, tablets.

Indications:

Proginova prescribed for endogenous insufficiency in the period menopause At oligomenoree , Gipomenoree, amenorrhea   (primary, secondary) dysmenorrhea After radiation Castration When secondary endogenous deficiency. The drug is effective at infertility , Gipogenitalizme, vaginitis, polycystic ovary syndrome, while virilnoe hypertrichosis   women to suppress lactation. Proginova indicated for alopecia (a form of hyperandrogenism), when urogenitelnyh disorders (trine, urethritis Atrophic vulvovaginitis , Dyspareunia), prostate cancer, breast cancer, breast. Proginova and pregnancy: the weakness of labor at term pregnancy. Men are not the drug is prescribed for acute radiation injury as a stimulant hematopoiesis .

Contraindications:

Proginova not indicated malignancy, troboflebite, uterine bleeding, genital bleeding nediganostirovannyh, with the active thromboembolic disorders . Thrombosis, pancreatitis . family hyperproteinemia , Severe liver disease, endometriosis, hepatitis, cholelithiasis, leiomyoma, hepatic porphyria, hypercalcemia drug is prescribed with caution.

Side effects, overdose:

Do females have an increased sensitivity, tenderness and breast enlargement, menorrhagia , Amenorrhea, mammary tumors, increased libido, intermenstrual spotting. In males there is a decrease in libido, gynecomastia , Sensitivity and tenderness of the breast. Proginova can cause anorexia, flatulence, biliary and intestinal colic, pancreatitis, hepatitis, peripheral edema, vomiting, obstruction of the gallbladder, dizziness. In a parallel treatment of prostate cancer and breast cancer may develop thrombosis, thromboembolism. In overdose recorded metrorrhagia, vomiting, nausea. It requires removal of the drug, the maintenance of body functions, posindromnaya therapy.

Mode of application:

Tablets Proginova take 21 days to 2 mg daily, and then make the seven-day break. Duration of therapy is 6 months, after which the doctor conducts a complete examination. Menopausal women and women with hysterectomy estradiol treatment can be started any day. Proginova administered intramuscularly in the form of 0, 1% estradiol dipropionate solution in oil. Secondary amenorrhea: 15 days 1 mg daily, administered before or progesterone pregnin 6-8 days. Proginova and pregnancy: in preterm pregnancy, the weakness of labor is administered by intramuscular injection of 4-5 mg before the administration rodostimulyatorov (2-3 hours).

Special instructions:

Before therapy with Proginova a compulsory medical and specialized gynecological examination. Treatment requires control over the work of kidney, liver, on blood pressure, blood counts biohimicheskimi. Make sure the combination of progestogen. Prolonged therapy can cause endometrial cancer, breast cancer. Proginova canceled 4-6 months before surgery. With the development and progression deep vein thrombosis , Jaundice, migraine, hypertension drug is discontinued.

Drug Interactions:

Proginova enhances the action hypoglycemic agents It weakens the effectiveness of anticoagulants, diuretics, antihypertensive agents. Metabolism of estradiol increases with simultaneous use of antibiotics, phenylbutazone, phenytoin, carbamazepine , Antiepileptic agents, narcotic analgesics, anxiolytics, tranquilizers, barbiturates. Thyroid medications, folic acid increases the effect of the drug Proginova.