Description overdue on 28.03.2012

Antigonadotropnym drug . The active component acts danazol . The basic material is prepared from ethisterone It is synthetic androgen . The principle of operation is aimed at suppression of gonadotropins FSH and LH from the pituitary gland under the direction of persons, male and female. Danol women leads to atrophy endometrial , Slows down the process Ovulation It reduces ovarian activity. Drug action reversible. High doses cause anabolic effects, the impact of weak adrogennoe. In patients with endometriosis   drug leads to atrophy inactivation ectopic endometrial tissue. Danazol lead to regressive changes in endometriotic lesions, reduces the severity of pain. There suppressive effect of the drug on lymphocyte proliferation, as well as immunosuppressive effect . Danol significantly reduces the production of autoantibodies in patients with endometriosis leads to a decrease immunoglobulins . When a hereditary form of angioedema clinical efficacy due to increasing content of C1 esterase inhibitor (congenital deficiency of the enzyme formed angioedema ). Danol when fibrocystic form mastitis   leads to the disappearance of nodular seals (partially and sometimes fully), relieves pain in full. Available in capsule form.

Indications:

Danol prescribed for   primary menorrhagia , Fibrocystic breast, benign tumors in the breast, with endometriosis infertility . The drug is effective in the hereditary form of angioedema, primary premature puberty, premenstrual syndrome .

Contraindications:

Danol not prescribed for porphyria, pregnancy, elevated levels of liver enzymes, breastfeeding, hypersensitive to danazol, heart failure, liver failure, kidney disease, when thromboembolism , Vaginal bleeding of unknown origin, while diagnoses androgen-dependent tumors . At migraine . diabetes , Disturbances of the hemostatic system, epilepsy prescribed with caution.

Side effects, overdose:

Danol hypersalivation may cause the sebaceous glands, the formation of "acne vulgaris", reduction of breasts, fluid retention, rush of blood to the face, hirsutism , Disruption of spermatogenesis , Emotional instability, vaginitis, dizziness, deepening of voice, nausea, visual disturbances, muscle spasm, lumbodynia , Sleep disturbances, paresthesia, thrombocytopenia, rash, hepatitis, dysmenorrhea , Alopecia, cholestatic jaundice, thrombocytosis, bleeding in patients with hemophilia, increased liver enzymes. If overdose is registered vomiting, nausea, convulsions, tremor of limbs, headaches, dizziness. Therapy posimptomnaya effectively gastric lavage.

Mode of application:

The drug is prescribed Danol from the first day of menstruation .  The capsules are intended for indoor reception .  In endometriosis prescribed initial daily dose - 400 mg, and the amount of active material is increased to 800mg, Propafenone - 6 months .  Preoperative preparation: a month before the surgery take 300-400 mg per day .  Average dose for an adult - 2-4 reception shared 200-800 mg per day .  To prevent a recurrence of inheritance, angioedema prescribed 200 mg daily, the dose is gradually reduced over three months in the absence of patient relapse .  In benign tumors of the mammary glands Danol take 3-6 months 100-300 mg .  When premenstrual syndrome and primary menorrhagia is shown receiving a dose of Danazol 100-400 mg per day for three months .  When gynecomastia in males appoint 200-600 mg per day .  For the prevention and relief of premature puberty in children: at 100-400 mg per day .

Special instructions:

It requires regular monitoring of the state of the doctor liver enzyme levels. People with diabetes should consult with the endocrinologist about the correct dose insulin . It is unacceptable to use the drug Danol as a method of contraception.

Drug Interactions:

Danol can reduce the effectiveness of hypoglycemic agents weaken the effect of insulin (drug affects carbohydrate metabolism, increases blood sugar levels). Danazol increases effects coumarin anticoagulants , Leads to the development of bleeding in the appointment of derivatives indandiona. The drug increases levels of glucagon in the blood, increases the concentration of cyclosporine and tacrolimus (increased risk of nephrotoxic effects). Danol able to inhibit the metabolism carbamazepine   in the blood increases its concentration.