Description overdue on 09/16/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Cautions
• Side effects
• Instructions for use Fliksotid
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Aerosol Fliksotid

1 dose aerosol inhalation Fliksotid may contain 50 ug, 125 ug and 250 ug Valium .

Auxiliary substances include propellant GR106642X.

Flixotide inhaler may contain doses of 60 or 120 doses. As part of the drug is absent freon .

Nebula Fliksotid

1 Nebula (2 ml suspension) for inhaled Flixotide may contain 0, 5 and 2 ml Valium .

Auxiliary substances include: sorbitan monolaurate, polysorbate 20, monobasic sodium phosphate dihydrate, anhydrous dibasic sodium phosphate and sodium chloride and water for injection.

Product form

Aerosol Fliksotid

Flixotide Aerosol for inhalation is produced in the form of a white slurry, which is placed in a metal inhaler. The inhaler has a concave base and a metering device equipped with a sprayer. With the purchase of a medicament note that on the surface of the inhaler and the valve had no visible defects.

Aluminum inhalers with dosing device, and detailed instructions for use are placed in cartons.

Nebula Fliksotid

Suspension for inhalation may also be placed on a nebula 2ml that 5 pieces packed in aluminum bags.

Aluminum packages of 2 pieces together with detailed instructions for use are placed in cartons.

Pharmacological action

The drug is Fliksotid GCS for inhalation, which has both a pronounced anti-inflammatory and a strong anti-allergic effect.

Experts advise to use the drug in treatment asthma   at different stages, chronic bronchitis .   emphysema As well as other diseases that cause which is airway obstruction.

Pharmacodynamics and pharmacokinetics

Fluticasone propionate   It has an impact not only on the proliferation of mast cells, lymphocytes and eosinophils, and macrophages, and neutrophils. Also fluticasone   reduces the production of biologically active substances such as histamine, prostaglandins . leukotrienes . Cytokines And the release of inflammatory mediators.

High efficiency showed the drug in COPD (chronic obstructive pulmonary disease), thus reducing the need to receive additional course of GCS in the form of tablets and improve the quality of life of the patient.

Systemic action fluticasone propionate marginally when receiving therapeutic doses of the drug does not affect hypothalamic-pituitary-adrenal axis .

The peculiarity of this drug is that fluticasone   It helps to restore the patient's response to bronchodilators that can significantly reduce the frequency of their use.

The therapeutic effect after inhalation evident after 24 hours and reached its peak after about 2 weeks or more after the start of dosing. The effect of the cancellation takes several days.

Absorption

After inhalation bioavailability fluticasone propionate   dostigaet10-30% depending on what type of inhaler is used. The absorption process takes place in the lungs. Note that a part of the dose may be swallowed, but its effect is minimal, since fluticasone   poorly soluble in water.

Allocation

Relationship to plasma proteins is quite high and amounts to over 91%. Fluticasone propionate   has great Vd, which is 300 liters.

Metabolism

The process metabolism fluticasone liver occurs involving CYP3A4. As a result, metabolism inactive forms metabolite .

Withdrawal

Fluticasone   peculiar to a sufficiently high plasma clearance. It is listed as 1150 ml / min. T1 / 2 up to 8 hours. Renal clearance fluticasone   It varies between 0 and 1 and 0.2%. The drug appears in urine (less than 5%).

Indications

It is recommended to use the drug Fliksotid:

• at asthma (basic anti-inflammatory therapy);
• in chronic   obstructive pulmonary disease .

Contraindications

Do not use aerosol Fliksotid:

• acute bronchospasm ;
• at status asthmaticus   (as the main drug);
• at bronchitis neastmaticheskoy nature ;
• children under 1 year;
• hypersensitivity to any component of the formulation.

With extreme caution should be used Fliksotid:

• in the course of treatment cirrhosis ;
• at glaucoma ;
• at hypothyroidism ;
• in the presence of systemic infections (bacterial, parasitic, fungal, viral);
• at osteoporosis ;
• in the course of treatment pulmonary tuberculosis ;
• at pregnancy   during Lactation .

Cautions

Flixotide is used only for long-term treatment asthma And not to only stop attacks. For relief of severe attacks specialists prescribe inhaled bronchodilators, which have a short duration of action.

It should always be remembered that the sudden and highly progressive deterioration Asthma   It can be a serious threat to life. If the need for the use of short-acting bronchodilators increases, you must consult your doctor and review the treatment regimen.

Physicians are advised to avoid abrupt withdrawal   Fliksotid drug.

You should always check whether a patient has the skills proper use of the inhaler.

When transferring patients hormone-dependent bronchial asthma   with systemic corticosteroids to fluticasone need to pay special attention to how the process of recovery of adrenal function.

Required regular monitoring of adrenocortical function and compliance with the maximum caution in the case of reducing the dose of systemic corticosteroids.

Experts recommend patients to gradually reduce the dose of systemic corticosteroids within a week after the appointed fluticasone .

Many patients after they began to lower the dose of systemic corticosteroids, complain of malaise, but it should not lead to the abolition of the transition in the event that the patient no signs of adrenal insufficiency.

It is recommended for the gradual abolition of systemic corticosteroids in the background fluticasone   be in possession of the card, which will indicate that during a stressful situation may urgently need an extra dose of corticosteroids.

When switching to inhalation therapy the patient may feel discomfort from hypereosinophilic   (e.g., Churg-Strauss syndrome ), As well as exacerbation of concomitant allergic diseases (e.g. Allergic rhinitis . eczema ).

In order to prevent candidiasis   It is recommended after each use Fliksotid rinse your mouth with clean water. If necessary, the doctors in the course of treatment may be given drugs for local antifungal therapy.

In order to avoid hoarseness   vote is needed after use of the drug is also rinse the throat and mouth with clean water.

If during the reception begins Fliksotid development paradoxical bronchospasm , You must immediately complete the drug and to choose other drugs. Paradoxical bronchospasm in the shortest time necessary to stop using a fast inhaled bronchodilators.

Some patients also complain significant increase in blood glucose level, and assign blows fluticasone propionate   with people diabetes .

Note that the drug could partially lose its under cooling.

Use in Pediatrics

With long-term use of inhaled corticosteroids dynamics of growth of children should be constantly monitored.

Effects on ability to drive vehicles and management mechanisms

Fliksotid can be used for driving and handling equipment, as its effect on the power of the minimum.

Side effects

The course of treatment Fliksotid patients may feel uncomfortable:

• from candidiasis   oral cavity and pharynx;
• from hoarseness ;
• from paradoxical bronchospasm ;
• from the appearance of allergic reactions ( skin rash, angioedema, dyspnoea or   bronchospasm, anaphylactic reactions );
• by reducing the function of the adrenal cortex;
• from osteoporosis ;
• from stunting   (in children);
• from Cataract ;
• from elevated intraocular pressure .

Instructions for use Fliksotid

Aerosol Fliksotid

In accordance with the instructions on Fliksotid this drug should not be used to treat children under the age of 1 year.

The recommended dose for children up to 4 years of age is 100 mg 2 times a day.

In the course of treatment for children older than 4 years, experts recommend the use of an aerosol, which contains 50 mcg Valium   in one dose. It should be used for 50-100 mg 2 times a day. The initial dose should be determined by the physician and it depends on the general condition of the patient. During the treatment and taking into account the individual patient's response to drug dose for inhalation can be either increased or decreased.

Note that in the treatment of young children require higher doses compared with the doses used in treatment of older children. This is due to the fact that young children significantly reduced intake of the drug administered by inhalation due to the smaller bronchi, use a spacer, as well as heavy nasal breathing.

The drug must be administered using an inhaler through a spacer with a mask.

Adults and adolescents over 16 years prescribed 100 micrograms to 250 micrograms Friksotida 2 times a day as initial dose at mild asthma . With an average course of the disease are advised to take 250 to 500 mg 2 times a day. In severe disease prescribe 500 mg to 1000 mg 2 times a day. During treatment dose may vary in smaller and larger parties.

Nebula Fliksotid

Fliksotid Nebula is used in both oral (via mouthpiece) and nasal (via face mask) inhalation. The drug administered as an aerosol from a nebulizer. Only use jet nebulizer and renounce the use of ultrasound. If necessary, allowed to breed before inhalation suspension Fliksotid in physiological sodium chloride solution.

The treatment regimen for children aged 4 to 16 years includes 1 mg fluticasone   Two times a day. Adults and adolescents over 16 years are usually prescribed dose, which varies between 0, 5 mg, and 2 mg fluticasone 2 times a day. It is recommended to use the maximum dosage for only 7 days after the attack, and further dose   fluticasone   you must gradually decrease.

Overdose

In acute overdose can cause a temporary loss of function of the adrenal cortex . In this situation often does not require extra therapy due to the fact that the function of the adrenal cortex may be reduced for several days.

Fliksotid Taking high doses for a long time, can greatly harm the function of the adrenal cortex. It is rare, but still present, reported that taking the drug for a few years or months has provoked the development of children adrenal crisis , Which is characterized by symptoms such as convulsive state, depression of consciousness and   hypoglycemia .

Note that the cause of acute adrenal crisis can become severe trauma, surgery, infection, and sudden reduction of the dose fluticasone .

If the patient receives a dose that exceeds recommended, it must be gradually reduced.

Cooperation

Fliksotid interaction with other drugs is minimal due to the fact that the concentration Valium   plasma levels sufficiently low.

With extreme caution should be taken in conjunction with Fliksotid inhibitors of the enzyme CYP3A4 As this may cause amplification of systemic exposure Fliksotid.

Terms of sale

Fliksotid can be purchased at the pharmacy on prescription.

Storage conditions

Regardless of the form in which the drug is released Fliksotid it must be stored in rooms where the temperature does not exceed 25 ° C, away from direct sunlight.

In no event should not be frozen drug, as it has completely lost its effectiveness.

Nebula, which are taken out of the aluminum package, must be used within 28 days and stored entirely protected from sunlight.

After Nebula opened, it can be stored in an upright position a maximum of 12 hours at a temperature not exceeding 15 ° C.

Shelf life

Fliksotid stored for 2 years when stored.

Analogs

At the moment, the most popular drug analogues Fliksotid are: Soderm, desoxycorticosterone trimethylacetate   and Ftorometolon . Well proven and Ftorgidrokortizona acetate   and Deksokort .

Reviews Fliksotid

Average rating Fliksotid (Flixotide) on the forums is 4, 7 to 5-point scale.

The advantages of the drug Visitors forums include:

• quick effect;
• easy to use;
• well tolerated;
• that is issued free of charge to asthmatics.

However, reviews of Fliksotid emphasize and cons of the drug:

• high price;
• that is the hormonal drugs.

Information about the preparation Fliksotid (Flixotide) Wikipedia does not.

Price Fliksotid

Each dosage and the form of the drug Fliksotid has its price:

• Spray 50 mcg Fliksotid   (120 doses) can be bought for 435 rubles.
• Average price Flixotide 125 micrograms   (60 doses) is 640 rubles.
• And for An aerosol with a dose of 250 mcg   (60 doses) will have to pay an average of 930 rubles.
• 10 Nebula Fliksotid inhalation   at 0, 5 mg of today are 1570 rubles, and 2 ml - 2280 rubles.