Description overdue on 05.11.2012

Glucocorticosteroid . Active Ingredient - triamcinolone . The principle is based on the feedback inhibition of release of interleukin-1, 2, interferon-gamma from lymphocytes and macrophages. The drug has anti-allergic, anti-inflammatory, antishock, desensitizing, immunosuppressive, detoxifying effects. The drug does not reduce the level of circulating beta-endorphin, thus inhibiting the release of beta-lipotropina and ACTH by the pituitary gland.

Glucocorticosteroid inhibits the secretion of FSH, TSH increases the number of red blood cells by stimulating the production of erythropoietin, reduces the number of eosinophils and lymphocytes. Due globulins Kenalog reduces the amount of protein in blood plasma process enhances protein catabolism in muscle tissue. Under the effect of a drug is a redistribution of fat and its accumulation in the abdomen, waist, face, shoulder girdle. The medicament increases the synthesis of triglycerides   higher fatty acids, causes hypercholesterolemia. The medicament enhances the absorption of carbohydrates from the digestive tract, retains water and sodium ions in the body, increases the excretion of potassium ion, promotes "washout" of calcium from bone.

The anti-inflammatory effect is achieved by inhibiting the release of inflammatory mediators of eosinophils, reduction of the number of mast cells that produce hyaluronic acid. Allergy effect is the suppression of secretion of allergic mediators and synthesizing. By improving the level of blood pressure is achieved protivoshokovoe impact. Braking output Cytokine   (interferon gamma, interleukin-1, 2) from macrophages and lymphocytes provides an immunosuppressive effect. Under the influence of the drug decreases the possibility of scarring, inhibits connective tissue reaction in inflammatory processes. Kenalog is discharged as a slurry.

Indications:

Kenalog prescribed for shock (cardiogenic, operations, burns, toxic, traumatic) in case of failure of the therapy. The drug is effective in allergic reactions, anaphylactoid reactions, anaphylactic shock, blood transfusion shock, status asthmaticus , Asthma, rheumatoid arthritis, systemic connective tissue diseases, with tireotoksicheskom Stroke , Acute adrenal insufficiency, hepatic coma, acute hepatitis, for poisoning cauterizing liquids to prevent the formation of scar restrictions, reducing the severity of inflammatory reactions. Intra-articular medication is administered in synovitis,   bursitis , Tendonitis, traumatic arthritis. Intradermal injection is performed at a total alopecia, alopecia areata, keloids, lichen planus, the annular grinuleme, psoriasis, limited neurodermatitis .

Contraindications:

Joint injections are not permitted under abnormal bleeding, marked periarticular osteoporosis When periartrikulyarnyh infection after arthroplasty, with severe deformation and destruction of the bone joint, joint instability after arthritis. In diseases of bacterial, fungal and viral etiology, varicella, herpes zoster , Active and latent tuberculosis, strongyloidiasis, amebiasis   Kenalog 40 used with caution.

Side effects, overdose:

Endocrine system: Cushing's syndrome , Inhibition of adrenal activity, a manifestation of latent diabetes mellitus, the development of "steroid" diabetes, delayed sexual development in children. The digestive tract: erosive esophagitis "Steroid" ulcer in the gastrointestinal system, the development of pancreatitis, nausea, vomiting, elevation of liver enzymes. Cardiovascular system:   thrombosis, hypercoagulation , Increased blood pressure, increased severity of heart failure, bradycardia, arrhythmia. Nervous system:   manic-depressive psychosis, hallucinations . euphoria , Delirium, paranoia , Depression, disorientation , Dizziness, insomnia, seizures, pseudotumor cerebellum, vertigo, nervousness or anxiety , Increased intracranial pressure, headaches. Senses:   subcapsular posterior cataracts, sudden loss of vision, tendency to develop viral, fungal, bacterial infections, exophthalmos , Trophic changes of the cornea. Metabolism:   negative nitrogen balance, hypocalcemia , Increased excretion of calcium ions, increased sweating. Musculoskeletal system: reducing, muscle atrophy, "steroid" myopathy, tendon rupture, osteoporosis, slowing growth and ossification processes in children. Skin, mucous membranes:   propensity to develop candidiasis, pyoderma, striae, steroid acne, hypopigmentation, istontsenie skin, ecchymosis, petechiae, delayed wound healing. Perhaps the development of allergic reactions such as anaphylaxis, pruritus, rash. If overdose is marked Cushing's syndrome, glycosuria, hyperglycemia . Treatment posindromnoe if the gradual abolition of the drug.

Mode of application:

Kenalog injected intramuscularly deeply. The dosage for adults 40-80 mg, repeated administration is possible at 4 weeks as needed. In some cases the amount of drug increased to 100 mg. After a single administration of the drug after 1-2 days there is a decrease of activity of the adrenal cortex. Restore recorded 30-40 days. Perhaps intraarticular injection of 10 mg of the drug.

Special instructions:

It is unacceptable intravenous infusion. It is recommended to avoid over-distension of the joint capsule in the intraarticular injection Kenalog 40.

Drug Interactions:

Kenalog is incompatible with other medicines due to risk of the formation of insoluble compounds. The drug speeds up the process of removing acetylsalicylic acid Increases toxicity cardiac glycosides , Enhances metabolism of mexiletine, isoniazid. The drug increases the severity of hepatotoxic effect of paracetamol increases the level of folic acid. High dosages result in reduced effectiveness of somatropin. While taking antacids marked decrease absorption of medication. Kenalog reduces praziquantel in blood plasma. Ketoconazole reduces the clearance and inhibits the metabolism of tacrolimus.