Description overdue on 02/07/2013

Antithyroid drug . Active ingredient - tiamazol . The mechanism of action of the main component in the blocking direction peroxidase   - An enzyme that participates actively in the process of iodization thyronine in tissues Thyroid the formation monoyodtironina, diiodothyronine, and subsequently tetraiodothyronine and triiodothyronine. The drug inhibits the process of synthesizing hormones in the tissues of the thyroid gland, reduces the internal hormone T4 accelerates removal of iodides from thyroid tissue, basal metabolism slows down, and enhances the production of synthesis reciprocal hormone pituitary TSH, resulting in thyroid hyperplasia. In many ways, the speed of development of the therapeutic effect depends on the initial level of hormones T3, T4. The average decline in hormones recorded a week after the start of treatment Merkazolil 30 mg; or a month when receiving 40 mg. After the cessation of treatment the level of hormones can return to the former level already through a 5 days. Merkazolil available in tablet dosage form.

Indications and contraindications:

Drug Usage Merkazolil recommends prescribers in diffuse Struma thyrotoxicosis. The drug is indicated for use in nodular goiter, postoperative recurrence of hyperthyroidism. The drug is prescribed in addition to the radiojodterapii .
Merkazolil contraindicated during breast-feeding, with granulocytopenia, intolerance tiamazol active component, with severe leukopenia. When carrying a pregnancy, severe liver disease, if the crop is very large with a concomitant narrowing of the trachea (only preoperative short course) a drug is prescribed with caution.

Side effect:

Aplastic anemia, thrombocytopenia, allergic reactions such as hives   and skin rashes, granulocytopenia, suppression of myelopoiesis, generalized lymphadenopathy , Gipoprotrombinemii (are manifested in the the form of bleedings and petechiae), medicamental fever, an insulin an autoimmune syndrome, violations of of gustatory perception, neuritis , Sialadenopatiya, volchanochnopdobny syndrome, polyneuritis, alopecia, hepatitis, periarteritis , Vomiting, arthralgia, epigastric pain, cholestatic jaundice, nausea, fatigue, dizziness, paresthesia, myalgia, hyperpigmentation   skin, headaches, fever, rarely develop nephritis.

Overdose:

Manifested fever syndrome, nausea, edema, pruritus, epigastric pain , Vomiting, arthralgia. In the first few hours may develop agranulocytosis, pantsitoenii, aplastic anemia . Rarely recorded nephrotic syndrome , Neuropathy, stimulation or depression of the central nervous system, hepatitis, exfoliative dermatitis. Prolonged treatment with high doses leads to hyperplasia   of tissues thyroid gland. In case of overdose the stomach should be washed Thiamazolum appoint chelators, hold posindromnuyu therapy.

Mode of application:

Merkazolil Inside, after a meal. Hyperthyroidism mild to moderate: 3-4 times a day to 5 mg. Upon reaching remission (approximately 1-1, 5 months) daily amount of the drug is reduced by 5-10 mg every 5-10 days, to achieve progressively the minimum dose (1 every 3 days or 1 per day to 5 mg) which were capable of stable therapeutic effect. Severe hyperthyroidism: 3-4 times a day by 40-60 mg per day after stabilization to reduce the dose of 5-10 mg per day. The course of therapy is designed to 1-1, 5 years. The highest dosage: daily - 60 mg single - 10 mg.

Special instructions:

It is important to warn patients about the need to seek medical care when a Boils Inflammations of the mouth, cough, fever, febrile syndrome, sore throat, since said occurrence of these symptoms may indicate the development agranulocytosis . During treatment requires a compulsory control of the peripheral blood. To prevent the growth of the crop in the largest Struma of thyroid gland with concomitant narrowing of the trachea Merkazolil drug treatments are carried out only a short time. At occurrence of on the background of of therapy jaundice , Persistent vomiting or nausea, skin rashes and itching, bruising and bleeding of unknown origin, severe epigastric pain medication overturned. In case of early termination of the treatment of relapse of the underlying disease. Reviews to the drug Merkazolil testify to high of efficiency of of medicament at observance of specified recommendations.

Drug Interactions:

Reserpine, drugs, lithium, amiodarone, beta-blockers   capable of increasing the efficiency of Mercazolilum, which requires a mandatory correction dosing regimen. With an excess of iodine there is a weakening effect of the drug, and iodine deficiency - increased. Risk leukopenia   increases in the treatment of of Metamizolum of of sodium and sulfonamides .