Description overdue on 17.02.2012

Glucocorticosteroid . Active ingredient - mometasone . Nasonex has anti-allergic and anti-inflammatory effects expressed. The medicament facility applies topically, not causes the development systemic side effects. The mechanism of action of the drug is based on the suppression of release inflammatory mediators . Mometasone enhances the production of an inhibitor of phospholipase A - lipomodulina That conducts to decrease Released arachidonic acid , Inhibition of the synthesis prostaglandins , Cyclic endoperoxides and other products of metabolism of arachidonic acid. Nasonex by preventing accumulation of neutrophils boundary reduces production lymphokines It reduces the inflammatory exudate slows infiltration and granulation, inhibits the migration of macrophages. Mometasone brakes "immediate" allergic response. Prolonged therapy does not lead to the suppression of the hypothalamic-pituitary and adrenal systems. Mometasone has negligible bioavailability when used in inhalation basic substance practically in the blood is determined. The suspension is poorly absorbed in the digestive tract, so that a small amount of the drug that can get into the digestive system during inhalation, undergoes active metabolism before excretion in the bile and urine. Clinically significant effect was seen 12 hours after the first use of the drug. Nazoneks available as a nasal, a metered spray (white slurry).

Indications and contraindications:

Nasonex is used for treatment of allergic rhinitis (seasonal, year-round options). During exacerbation of sinusitis drug administered in combination with antibiotics. The drug effectively used for the prevention of seasonal allergic rhinitis (moderately, Severe). Nazoneks is not applied when of intolerance to mometasone. The drug is contraindicated in unhealed local infection in the nose, after traumatic injuries and surgical interventions on the nose. Nasonex is not prescribed for fungal, systemic viral, bacterial infections, tuberculosis   the respiratory system, with the defeat of herpes. Mometasone is not used in pediatric practice before reaching the age of two.

Side effect:

Nasonex can cause dryness, itching, irritation, burning, atrophic processes   in the nasal mucosa. Use of the drug can cause bronchospasm, candidiasis . pharyngitis , Stretch marks, secondary infections, hypertrichosis , Nosebleeds. Long-term use can cause the formation of systemic side effects. In the application of mometasone during pregnancy notes adrenal insufficiency   in children after birth.

Mode of application:

Preventive maintenance of allergic response : 2 inhalations (50 mg) in each nasal passage once a day. In day not more than 20 mkg. The multiplicity of the drug may be increased to 4 per day. After the disappearance of the disease gradually reduce the dosage of mometasone. Supportive therapy : 50 milligrams per day to 100 milligrams. Treatment for sinusitis 100 mg (2 inhalation) twice a day. Before using metered spray is recommended to do 6-7 injections into the air to establish a stereotypical drug delivery.

Special instructions:

Nazoneks not used in the ophthalmic practice. During the application of mometasone recommended to regularly inspect the nasal mucosa: the development of fungal, bacterial infection, treatment should be stopped. Before using Nasonex spray bottle is shaken.