Description overdue on 12-12-2011

Topical glucocorticosteroid . The pharmacological activity of synthetically derived substances fluocinolone acetonide   similar to glucocorticosteroids. The drug molecule shows two additional sinaflana fluorine atom facilitating greater anti-inflammatory effect and reduce local absorption. Fluocinolone atsitonidu characterized by high glucocorticoid activity. Mineralocorticoid action, he practically does not possess. At local application sinaflana ointment has anti-inflammatory, protivozudnoe and antiallergic action, as well as contributes to local vasodilation . The principle of action of the drug is to inhibit phospholipase A2 . Inhibiting the activity of this enzyme prevents the conversion of drug arachidonic acid   in active form. Due to this, there is a decrease amount prostaglandins   and leukotrienes Which acts as the main mediators of the inflammatory process. The drug promotes the release histamine   from mast cells That reduces the risk of hypersensitivity reactions. The action of the active drug substance sinaflana narrows the lumen of blood vessels, reducing the likelihood of developing exudative reactions. The drug has an effect on proteometabolism Reduces synthesizing protein reduces collagen deposition.

When topically applied drug is absorbed through the stratum corneum of the skin and its accumulation in the dermis. On day 15 after the application of significant concentrations determined fluocinolone. In the skin, the drug is not biotransformed. The process of systemic absorption is negligible, when applying ointment on skin hypersensitive (person damaged areas), it can be amplified. In cases of application of the drug under an occlusive dressing or extended its application to large areas of skin systemic absorption   increases. In adolescents and children, the absorption of topical corticosteroids systemic nature is higher compared to adults.

Indications:

Sinaflana used to treat skin diseases requiring glucocorticoid therapy: psoriasis, planus   and discoid lupus erythematosus . seborrhea   skin, eczematous lesions of different localization, neurodermatitis, allergic skin diseases and pruritus of various etiologies, first-degree burns, including sunburn, insect bites.

Contraindications:

Sinaflana contraindicated in the presence of individual hypersensitivity to the components of infectious diseases of the skin of various etiologies, ulcerative lesions and open sores on the relevant areas of the skin, tuberculosis of the skin . The drug is contraindicated for use during pregnancy, breastfeeding.

Side effect:

Long-term topical application of the drug may cause sinaflana patients skin atrophy   until her necrosis. Application of the drug on the sensitive areas of the skin, as well as applying it to the vast tracts epidermis   for a long time can cause systemic side effects characteristic of funds from a group of corticosteroids ( hypoadrenalism ).

Mode of application:

The ointment is applied 1-3 times a day, a thin layer of lightly rubbing. A full course of treatment with ointment sinaflana is 5 - 10 days, which if necessary can be extended to 25 days.

Special instructions:

The tool is not advisable to apply on large areas of skin as well as areas with increased sensitivity of the skin. Particular caution should be applied to the drug to teenagers, who are at the stage of puberty, as well as infants.

Drug Interactions:

With antimicrobial agents drug is fully compatible, and helps to prevent secondary bacterial infection. Use of the drug reduces the effect of diuretics, antiarrhythmic and antihypertensive drugs, and drugs potassium. In combination with diuretics, except for potassium sparing increases the likelihood of hypokalemia .