Description overdue on 01/29/2013

Antithyroid drugs.   The active component is tiamazol . The basic principle is based on blocking effects of enzyme peroxidase Which takes part in the process of iodination thyronine tissue Thyroid   with the formation of mono-, di-, tri- and tetraiodothyronine. The drug reduces the internal secretion of the hormone T4, breaks the process of synthesizing hormones   thyroid gland. Tirozol accelerates the removal of iodides from thyroid tissue, basal metabolism slows down, it amplifies reciprocal activation of hormone synthesis and release of pituitary TSH, resulting in thyroid hyperplasia. Speed ​​achieve a therapeutic effect depends on the index of the initial concentration of hormones T3 and T4 (in most cases normalization of observed after 4 weeks when receiving 40 mg or 1 week while receiving 30 mg). After the abolition of the drug increasing hormone levels observed on day 5. Tirozol available in tablet dosage form.

Indications:

Drug Usage tirozol contains the following indications: hyperthyroidism ( diffuse Struma ), Nodular goiter. The drug is administered before surgery, for intermediate or pre-treatment for the upcoming radioiodine therapy. The drug is indicated for use in the postoperative recurrence of hyperthyroidism.

Contraindications:

Tirozol not prescribed for granulocytopenia , Severe leucopenia, intolerance tiamazol, breastfeeding. When diagnosing goiter giant size with a concomitant narrowing of the trachea (except for short-term treatment before surgery), with gestation pregnancy, liver failure tirozol used with caution.

Side effect:

Insulin Autoimmune Syndrome , Drug fever, suppression of myelopoiesis (thrombocytopenia, granulocytopenia, agranulocytosis), allergic reactions such as hives   and skin rash, generalized lymphadenopathy, aplastic anemia , Gipoprotrombinemii in the form of bleeding and petechiae, lupus-like syndrome, disorders of taste perception, neuritis , Sialadenopatiya, itching . cholestatic jaundice , Periarteritis, expressed weakness throughout the body, epigastric pain, nausea, hepatitis, vomiting, arthralgia , Nephritis, edema, hyperpigmentation of the skin, dizziness, headache, paresthesia, myalgia .

Overdose:

Manifested fever syndrome, epigastric pain, vomiting, nausea, edema, pruritus, arthralgia. In the first few hours may manifest agranulocytosis or aplastic anemia - pancytopenia . Rarely recorded neuropathy, exfoliative dermatitis Hepatitis, stimulation or depression of the central nervous system, nephrotic syndrome . Long-term therapy with high doses tiamazol leads to the gradual formation of thyroid hyperplasia. With an overdose of medication needed gastric lavage to prevent further absorption of the active substance, purpose enterosorbents   and carrying out the symptomatic treatment.

Mode of application:

Tablets tirozol taken after a meal inside. When thyrotoxicosis mild to moderate form tiamazol administered 3-4 times a day for 5 mg. By achieving remission after 3-6 weeks of daily amount of medication is reduced by 5-10 mg every 5-10 days until the minimum dosage of 1 mg five times in 3 days, 1 times a day or every other day. In severe thyrotoxicosis drug prescribed at a dose of 40-60 mg per day (in 3-4 hours). After stabilization, reduce the dose of 5-20 mg per day. The duration of therapy is designed for 1-1, 5 years. Higher dose for adults: daily - 60 mg, single - 10 mg. For pregnant women try to select the lowest possible dose - 2 5-10mg.

Special instructions:

It is important to warn patients about the need to seek medical care in case of fever, Boils , Inflammation of the mucous membranes of the mouth, sore throat, cough, chills, as these symptoms indicate the development of agranulocytosis. During the entire course of therapy required regular monitoring of indicators of work of liver, peripheral blood. For large Struma of thyroid gland with concomitant narrowing of the lumen of the trachea tirozol drug treatment is carried out only a short time because of the risk of goitre growth. When during treatment jaundice , Generalized skin rash, bleeding or bruising of an unknown origin, vomiting, persistent nausea, severe weakness in the whole body, severe epigastric pain tiamazol cancel (possible relapse). Responses to the drug tirozol testify to its high efficiency in compliance with all recommendations.

Drug Interactions:

Metamizole sodium, increase the risk of sulfonamides leukopenia . Beta-blockers, drugs lithium and amiodarone reserpine   able to enhance the effect of tiamazol, which may require correction dosing regimen. Excess iodine reduces the effect of the drug, and the deficit - increases. Gematotoksichnosti   Tirozol enhanced by the use of myelotoxic drugs.