Description overdue on 18.02.2012

Glucocorticosteroids.   The active substance acts beclomethasone . Effectively used in the treatment of bronchial asthma (basic therapy). Aldetsin has anti-allergic and anti-inflammatory effects of moderate severity. Beclomethasone enhances the production of the phospholipase A2 inhibitor - annexin (lipocortin), inhibits the production of inflammatory mediators, reduces the release arachidonic acid , Has a depressing effect on synthesizing products of arachidonic acid metabolism - prostoglandinov   and endoperekisey. The anti-inflammatory effects due to the inhibition of formation chemotaxis It slows down the formation of a slow allergic reaction. Belometaon improves mucociliary transport Reduces the number of mast cells in the bronchial mucosa, reduced giperreaktinost bronchi, reduces the secretion of mucus, bronchial gland generated. Aldetsin positive effect on functional indices of external respiration. The drug restores the patient's response to the impact of bronchodilators, which significantly reduces the frequency of their use. The drug increases the number of active beta-adrenergic receptors, has no resorptive effects inhalation use. Use of the drug Aldetsin at therapeutic doses does not lead to the development of systemic side effects associated with the use of corticosteroids. The therapeutic effect is formed gradually, the drug is not stopped   bronchospasm . Aldetsin produced in the form of capsules, powder, solution for inhalation of aerosol.

Indications and contraindications:

Aldetsin indicated for the treatment of bronchial asthma (basic therapy), the ineffectiveness of ketotifen, kromoglitsievoy acid bronchodilators . The drug can reduce the dosage of oral glucocorticosteroids. Aldetsin contraindicated in neastmaticheskom bronchitis, acute bronchospasm, intolerance beclomethasone, asthmatic status. With glaucoma , Liver cirrhosis, breastfeeding . osteoporosis . hypothyroidism . pregnancy , Systemic diseases (viral, parasitic, fungal, bacterial infections) administered with caution.

Side effect:

Irritation in the throat, hoarseness, sneezing , Cough, paradoxical bronchospasm , Oral candidiasis, allergies, eosinophilic pneumonia . With prolonged use of the drug in high quantities develop systemic side effects, adrenal insufficiency , Leukocytosis, increased intraocular pressure, dizziness, headache, eosinopenia, cataract , Lymphopenia. For a single high doses of the drug is registered Aldetsin reduced function of the hypothalamic-pituitary-adrenal and systems. Operation system restore yourself in 2 days.

Mode of application:

Aldetsin used inhalation. Asthma lung flow 2 inhalations of 200-600 micrograms. Asthma moderate:   2-4 inhalations per day in an amount of 0, 6-1 mg. In bronchial asthma, severe   administered 1-2 mg per day. The day is allowed to use no more than 2 micrograms of beclomethasone. Upon completion of inhalation, it is recommended to rinse the mouth with running water. The drug (250mkg per dose) is not used in pediatric practice. The introduction of the drug is carried out with the help of spacer   - A special dispenser that improve the process of distribution of beclomethasone in the lungs, reducing the risk of side effects. The dosage of a medicament for use in a powder for inhalation discs 200 micrograms (bekodisk) applied 2-4 times a day 200mkg.

Special instructions:

Aldetsin not apply for the relief of acute asthma attacks .  Patients should explain that the drug has a preventive effect, and that in order to achieve the maximum effect of the drug must be used regularly, including the absence of asthma symptoms .  Regular use of the inhaler makes it possible to improve the performance of respiratory function after a week of treatment .  The reason for the lack of effect can be to elevated levels of mucus and phlegm in the respiratory system, as well as a result of severe bronchospasm, which prevents the penetration of the zone of the beklomeazona .  Before the appointment of the drug Aldetsin physician should instruct the patient to talk about aspects of the correct use of the inhaler, that in the future will provide a better therapeutic effect is due to the complete penetration of the basic substance in the lungs .  When transferring a patient with oral glucocorticosteroid Aldetsin to hold regular   pikfluometriyu . After a week of treatment the daily dose of the drug reduced by 1mg every week. Washing after using the drug can prevent the defeat of the nose and eyelid skin. Aldetsin not be exposed to direct sunlight, spray must not be frozen. Spray after use, do not disassemble, puncture, dispose of in fire. Upon cooling aerosol body warm hands.

Drug Interactions:

Aldetsin allows to restore the patient's reaction to the use of beta-agonists That significantly reduces the frequency of their use. No significant drug interactions of inhaled corticosteroids with other medicines have been reported. Inductors of microsomal oxidation ( rifampicin , Phenobarbital, phenytoin) decrease the effectiveness of beclomethasone. Estrogens methandrostenolone , Theophylline, beta 2-adrenostimulyatorov enhance the effect of the drug Aldetsin.