Description overdue on 15.10.2011

Glucocorticosteroids. It has desensitizing . antiallergic . anti-inflammatory . antitoxic . protivoshokovym . immunosuppressive effect . Reduces the amount of protein in the blood, increases in albumin synthesis renal, hepatic systems, enhances the synthesis of higher fatty acids, provokes hypercholesterolemia.

Indications:

Dexamethasone prescribed for the ineffectiveness of the therapy in traumatic, toxic, surgical, burns, anaphylactic shock, transfusion shock . The drug is effective in swelling of the brain , Severe asthma, systemic connective tissue diseases, asthmatic status, rheumatoid arthritis SLE, tireotoksicheskom Stroke , Hepatic coma, acute hepatitis, poisoning cauterizing liquids (prevention of scarring, reduced severity of inflammatory responses).

Contraindications:

Intra: abnormal bleeding, septic process in the joint, intra-articular fracture, prior arthroplasty , Periarticular osteoporosis, joint deformity, severe bone destruction, "dry" joint. Dexamethasone is not prescribed for infectious diseases (bacterial, fungal, viral), parasitic infections, herpes zoster, amebiasis, varicella , Latent tuberculosis , System avium , Strongyloidiasis. The drug is not prescribed to patients with AIDS. Diseases of the digestive tract: esophagitis , Ulcerative lesions, intestinal anastomosis, peptic ulcers, nonspecific colitis . diverticulitis . CCC: myocardial infarction , Hypertension, decompensated chronic heart failure, hypercholesterolemia. Endocrine diseases: hypothyroidism , Thyrotoxicosis,   diabetes , Cushing's disease. Hypoalbuminemia, nefrourolitiaz, renal insufficiency, acute psychosis, myasthenia , Osteoporosis, obesity, glaucoma . polio Pregnancy.

Side effect:

Severity of side effects of the drug Dexamethasone depend on the dose and duration of drug use. Endocrine system: Cushing's syndrome , Adrenal suppression, hirsutism . dysmenorrhea , Increased blood pressure, obesity, pituitary type, "steroid" diabetes, amenorrhea , Striae, myasthenia gravis. GIT: dyspepsia, erosive esophagitis , Pancreatitis, gastrointestinal perforation, flatulence , Eating disorders, elevation of liver transaminases. CCC: bradycardia, arrhythmia, increased blood pressure, thrombosis, hypercoagulation . Nervous system: disorientation . delirium . hallucinations .   euphoria . paranoia , Depression, psychosis, anxiety, increased intracranial pressure, vertigo, insomnia, headache, pseudotumor cerebellum, convulsions . Sense organs: subcapsular back cataract Sudden loss of vision, exophthalmos , Trophic changes of the cornea. Metabolism: hypocalcemia, increased sweating, negative nitrogen balance, hypernatremia . Musculoskeletal system: osteoporosis, growth retardation, disturbance of ossification in children, before epiphyseal closure of areas, "steroid" myopathy , Muscle atrophy. Mucous membranes, skin: petechiae , Steroid acne, poor wound healing, thinning of the skin, ecchymosis, candidiasis . pyoderma . Allergies.

Mode of application:

Intraarticular: 4-16 mg, 1-3 times a week. Lesion: 0, 8-1, 6 mg dose. Intramuscular: 8-16 mg, about 3 times a week. Cerebral edema: initially 10 mg every 6 hours 4 mg intramuscularly. Shock: initially 20 mg, then 3mg / kg / in. Allergic reactions: Initially 4-8 mg intramuscularly.

Special instructions:

Dexamethasone prescribed during pregnancy only for health reasons, assessing the possibility of a negative effect of the drug on the fetus. In patients with hyperthyroidism dexamethasone increased clearance, and in patients with hypothyroidism - is reduced.

Drug Interactions:

Dexamethasone with other agents to form insoluble compounds increases the toxic effect of cardiac glycosides, reduces the concentration of ASA in the blood accelerates its excretion. The drug increases metabolism mexiletine . isoniazid It increases the hepatotoxicity acetaminophen It increases the concentration of folic acid. High doses reduce the effectiveness of the drug somatotropin , Hypoglycemic drugs. Dexamethasone reduces praziquantel   in blood. Ketoconazole   and cyclosporine   increase the toxicity of the drug. Theophylline, barbiturates, rifampicin, ephedrine , Phenytoin reduce the therapeutic effect of corticosteroids. Mitotane requires an increase in the dose of dexamethasone. Nitrates, Mr. holinoblokatory, tricyclic antidepressants Antihistamine drugs increase the intraocular pressure while the appointment of dexamethasone.