Description overdue on 09/29/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Octreotide, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

As part of the solution contains the active ingredient: Octreotide Submitted as a free peptide. Supporting components: sodium chloride and water d / and.

Octreotide depot includes in its composition: active substance - Octreotide, auxiliary components: a copolymer of DL-lactic and glycolic acids, D-mannitol, carboxymethylcellulose sodium salt, polysorbate 80, mannitol, and water for injection.

Octreotide Long composed of active substance octreotide acetate   and additional components: DL-lactic acid-glycolic acid copolymer, D-mannitol, carmellose sodium, polysorbate-80.

Product form

The drug is available as a solution for injection, placed in 1 ml ampoules or vials of 5 ml.

Octreotide depot and Octreotide Long-issued in the form of a lyophilized powder or compacted and the porous mass in the form of a light-colored pills in various strengths. Extras included a clear colorless solvent and reconstituted suspension is a homogeneous suspension of light shade.

Also these drugs variations can be offered in the form of a lyophilisate for suspension intended for intramuscular administration of a sustained action over 0, 01-0, 03g of the active ingredient in dark glass vials. Furthermore, in the package supplied with 2 ml solvent vial, disposable syringes, needles and sterile alcohol swabs. One set is designed for a single injection.

Pharmacological action

The drug has somatostatinopodobnym   action.

Pharmacodynamics and pharmacokinetics

This drug is a synthetic analogue somatostatin Having similar pharmacological effects, but the longer duration of action.

Octreotide treatment is performed when the required suppression of growth hormone secretion, increased or pathologically caused by arginine . insulin-induced hypoglycemia   or physical activity. This reduces Secretion of insulin, gastrin, glucagon   and Serotonin Which may also be increased or pathologically caused meals. Marked suppression of secretion insulin and glucagon Which stimulates   arginine , Decreased secretion thyrotropin Induced tireoliberinom .

Use of the drug before or during surgery on the pancreas to reduce the frequency characteristic of postoperative complications, such as:   pancreatic fistula, sepsis, abscesses, acute postoperative pancreatitis .

Treatment of bleeding varices in the gastrointestinal tract in patients with cirrhosis of the liver in combination with specific treatment - sclerosing hemostatic and contributes effectively to stop the bleeding and prevent rebleeding hold.

Inside the body there is a rapid and complete absorption of the active substance. The maximum concentration of Octreotide in the composition of the blood plasma is reached after 30 minutes. Component 65% bound to plasma proteins, but its relationship with the formed elements of the blood is very low. Withdrawal takes place in several phases through the intestine and kidney using.

Indications

Preparations based on Octreotide appointed at:

• acromegaly If marked inefficiency   dopamine agonists And if it is impossible to perform a surgical or radiation therapy;
• endocrine tumors   gastroenteropankreaticheskoy system;
• glucagonomas, gastrinoma;
• insuloma .   somatoliberinomah;
• refractory diarrhea   AIDS patients;
• operations on the pancreas, including the prevention of complications;
• bleeding , The prevention of recurrence in cases of esophageal varices in cirrhosis of the liver, and so on.

Contraindications

The main contraindication to the use of this drug is hypersensitivity.

Requires caution in patients cholelithiasis . diabetes . at Lactation   and   pregnancy.

Side effects

In the treatment of octreotide may occur irregularities in the digestive tract in the form of vomiting, nausea, anorexia , Pain, bloating, diarrhea, from teatorei, ileus, acute hepatitis   without cholestasis, increased activity of hepatic transaminases, hyperbilirubinemia, acute pancreatitis   and others.

It may also develop   alopecia   and allergic reactions . Not excluded, and local manifestations: pain, itching, burning, redness   or swelling . Long-term use is often accompanied by the formation of gallstones, impaired glucose tolerance, reception hyperglycemia, hypoglycemia.

Octreotide, instructions for use (method and dosage)

The drug is intended for Octreotide intravenous, intramuscular   or subcutaneous . The dosage is determined individually, taking into account the nature of the disease and the patient. For example, tumors, acromegaly and gastroenteropankreaticheskoy systems require subcutaneous administration 1-2 times daily 50-100 micrograms. Prophylaxis of complications resulting from the transferred transactions in pancreas, suggests subcutaneous administration of the first dose one hour prior to laparotomy, then administered daily for three times with 100 micrograms per week. When you want to stop the bleeding variceal gastrointestinal administered continuous intravenous infusion of 25 mg / h for at least 5 days.

Instructions for use Octreotide depot   and Octreotide Long-FS   It reported that they are intended for deep intramuscular injection   in the buttock. When patients subcutaneous injection of Octreotide can adequately control the manifestation of the disease, prescribed initial dose depot and Long of 20mg, every 4 weeks for 3 months. Thereafter, the dosage is adjusted depending on the biological markers of the disease and clinical symptoms.

If earlier the patients had not received subcutaneous octreotide, you should begin therapy is this tool and a way for 2 weeks. This approach will enable it to evaluate the efficacy and tolerability, then you can perform the treatment Octreotide depot or Long.

Overdose

In case of overdose of octreotide or octreotide Long may occur: short-term slowing of the heart rate . abdominal pain   spastic character, nausea , Flushing, diarrhea . Thus symptomatic treatment.

Overdoses of octreotide depot in clinical practice are not described.

Cooperation

Simultaneous use of the drug with   cyclosporine It lowers the level of serum in the composition slows the absorption   cimetidine   and the useful components from the gastrointestinal tract. When administered with Octreotide   insulin Orally hypoglycemic agents .   beta-blockers BPC and diuretics .   you must adjust their dosage. Concomitant use with bromocriptine   may enhance its bioavailability.

It is found that the drug reduces the metabolic clearance of compounds which are metabolized by cytochrome P450 induced suppression of growth hormone. Therefore, the appointment of these drugs with caution.

Terms of sale

Each form of the drug is released strictly on prescription

Storage conditions

For storage of drugs is necessary to ensure a dry, dark place at a temperature of 2-8 degrees, well protected from children.

Shelf life

Lyophilisate and solvent can be used for 3 years.

Depot and preserve the availability of long - 2 years. Formulation retains its effectiveness for no longer than 6 hours.

Analogues Octreotide

In pharmacology are numerous analogues octreotide, the main one - Sandostatin.

Such actions have:   Somatostatin, Diferelin   and Sermorelin .

Alcohol

It is known that alcohol can inhibit the synthesis of hormones, so its use with any form of Octreotide is contraindicated.

Reviews of octreotide

It should be noted that the discussion in the network regarding the application of this drug and its effectiveness are rare. Typically, users ask questions of experts in which interested how effective therapy is of a violation.

However, in clinical practice mainly used depot form. At the same time feedback on Oktireotid depot show that it is used pancreatitis As well as acute and chronic forms of the disorder. Of course, this facility shall be appointed by a specialist, and it is expected that the treatment will be carried out at least a week.

Price octreotide, where to buy

Buy in Moscow Octreotide Long-FS 10 mg in the form of microspheres for the preparation of drug suspensions intended for intramuscular administration may be in the range of 30-32 thousand. Rubles.

Price Octreotide depot 20 mg of 46-48 thousand. Rubles.