Description overdue on 07/21/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Omnadren 250 (Method and Dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation Omnadren 250 includes a mixture of esters Testosterone : Testosterone propionate . Testosterone izokaproat . Testosterone kapronat . Testosterone phenylpropionate .

Also as part of the drug have further ingredients: Peanut oil for injection, benzyl alcohol.

Product form

Means produced in the form of an oily solution for injection. This pale yellow oily liquid, which is in the 1 ml ampoules. Realized in cardboard packs of five vials each.

Pharmacological action

Omnadren 250 - is an androgenic drug, which contains a mixture of testosterone esters. This hormone is directly involved in the formation of the testes, seminal vesicles, prostate, and also participates in the development of secondary and tertiary sexual characteristics. In addition, testosterone determines the formation of the general constitution of the body, as well as the sexual behavior of the person, it enhances the potency and sexual attraction, activates the process of spermatogenesis, makes less pronounced symptoms of menopause in men.

Testosterone - is an antagonist estrogen , Female hormones. Under his influence marked inhibition of gonadotropic function pituitary , Inhibits the function of the female breast. A patient who is undergoing a course of the drug can observe the phenomenon masculinization .

Testosterone acts as anabolic: it accelerates the process of protein synthesis, enhances the retention of calcium in bone, increases muscle mass, increases the Hemoglobin   blood, stimulates production Erythropoietin kidney.

If exogenous testosterone administered to healthy man, he says endogenous depression, that is, their own testosterone, as noted a decrease in the secretion of LH. When high doses of the drug inhibited spermatogenesis because the drug affects the reverse braking FSH .

In the treatment of testosterone men who have marked functional impairment pituitary , There is a growing symptoms hypogonadism . However, with the development of impotence due to not hypogonadism and other reasons, the treatment does not eliminate the drug problem.

Pharmacodynamics and pharmacokinetics

Testosterone ester available as part of Omnadren 250, have different absorption rate and the rate of excretion from the body, due to which there has been rapid effect and lasting effect means (about four weeks) after a single administration. If exposure to testosterone propionate It occurs during the first days after administration, the testosterone phenylpropionate and   izokapronata It affects the body only after 24 hours after its administration.

Testosterone kapronat   has been in a period when the impact of testosterone izokapronata and phenylpropionate not marked.

The plasma protein preparation binds 98%. Metabolism occurs in the liver, resulting in 17-ketosteroids appear. Once they are connected with glucuronic acid or sulfuric acid, is their excretion in the urine.

90% of the drug out through the kidneys as a metabolite, 6% - unbound form through the intestines.

The half-life of testosterone from the body is 10-100 minutes.

Indications

The drug is indicated for the treatment of women in the following cases:

• at post-castration syndrome ;
• at eunuchoidism ;
• at oligospermia ;
• at hypopituitarism ;
• at displays male menopause ;
• at Impotence ;
• at infertility ;
• the shortage androgens   (This condition is typical for pituitary dwarfism . Addison's disease . adipozo-genital syndrome ).

For the treatment of female drug is used in these cases:

• at osteoporosis Which develops as a result of lack of androgens;
• at displays Breast Cancer ;
• at   ovarian cancer ;
• at Hyperestrogenism , Accompanied by dysfunctional uterine bleeding;
• at endometriosis   and uterine cancer ;
• at displays premenstrual tension syndrome ;
• the symptoms that accompany a period Menopause ;
• with a view to virilization of the external genitalia at hermaphroditism .

Contraindications

Do not treat Omnadrenom 250, if a person are the following diseases or conditions:

• suspected carcinoma of the prostate or a diagnosis is established;
• hypercalcemia   and hypercalciuria ;
• gynecomastia ;
• heart, kidney or liver failure ;
• asthenia ;
• Use for the treatment of elderly men and boys in the prepubertal period;
• pregnancy and lactation;
• a high level of sensitivity to the facility.

Side effects

In the course of treatment may occur following side effects:

• The functions of the endocrine system: women can celebrate Development dysmenorrhea . masculinization . hirsutism , Slowing gonadotropin secretion; men can celebrate violation spermatogenesis , Development oligospermia . gynecomastia . priapism ; in the treatment of boys there may be too active puberty.
• The functions of the reproductive system: violation of human libido.
• The reactions of the skin: the emergence of blackheads . baldness   male pattern.
• The functions of the digestive system: the development of nausea Manifestation liver tumors . cholestatic jaundice . hepatic purpura , Disruption of the functioning of the liver.
• In the processes of blood coagulation: slowdown number of plasma coagulation factors, the manifestation of bleeding in people who take drugs with anticoagulant effect.
• The functions of the central and peripheral nervous system: the manifestation of headaches, paresthesia, anxiety.
• In the process of metabolism: increase in cholesterol   in blood plasma.
• Perhaps the manifestation of local reactions and pain in the place where the injection is administered.

Instructions for use Omnadren 250 (Method and Dosage)

Instruction in Omnadren 250 provides that the patient is assigned to administration of 1 ml of product every 28 days. As stabbing the drug should ask your doctor in detail, but on the instructions he is given intramuscularly in the gluteal muscle deep. Dosage sets PCP, it depends on the indication and the patient's response to the introduction means.

Instructions for use Omnadren 250 provides that if the primary male hypogonadism   is administered intramuscularly once a 7 or 14, or 21 days. The frequency of administration depends on the degree of gonadal failure patient.

With menopause   the man practiced administering omnadren 250 once in 14 days after the treatment effect becomes remarkable, must go to the introduction means 21 once a day.

When the men infertility   Omnadren 250 administered at a dose of 2 ml every 14 days. If a man in the course of therapy there is soreness of the penis during erection, treatment should be stopped.

With Menopause   the woman is assigned to 1 ml every 14 days or 21 days.

With   Ovarian Cancer Disease or Breast administered 1-2 ml once every 7 or 14 days over a prolonged period.

Overdose

There are no data on overdose Omnadren 250.

Cooperation

If patients in parallel with the treatment of 250 Omnadrenom get inside anticoagulants must be carefully monitored constantly indicators clotting.

People suffering diabetes When receiving androgen drugs may decrease blood glucose levels, it may also be desirable to use insulin.

If Omnadren 250 is applied at the same time with ACTH or corticosteroids may increase the risk of peripheral edema, especially those people who suffer from liver diseases or ailments of the cardiovascular system.

The effects of testosterone may decrease under the joint treatment of PM tools and techniques that encourage induction of microsomal liver enzymes .

Terms of sale

The drug is sold in pharmacies by prescription.

Storage conditions

Omnadren 250 must be maintained in a dark place, the temperature must be from 15 ° to 25 ° C. If the solution appears pellet-like flakes, the ampoule need for a time to lower the water temperature to 37 ° C.

Shelf life

Shelf life funds - 3 years.

Cautions

It should not be administered by intravenous means.

During the treatment of androgen in patients with breast cancer may develop as a result of hypercalcemia stimulating osteolysis . This may strengthen the system in bone metastasis. If treatment Omnadrenom 250 appointed a woman, you need to ensure control of the calcium concentration in the serum.

If androgen drugs are prescribed in large doses, it is necessary to constantly monitor the content of hemoglobin and hematocrit.

If a patient shows signs of hepatitis, jaundice, changes in liver function, a means to cancel, to establish the diagnosis and etiology of such changes. It is important to carefully monitor liver function.

In the treatment agent in elderly men increases the likelihood of developing prostate cancer and hypertrophy. It is important before starting treatment and in its process to conduct a study of the prostate, as well as control the level of PSA.

It should cancel means if marked human kidney, liver, cardiovascular system, and peripheral edema.

Carefully appointed Omnadrenom treated 250 patients who celebrated delayed puberty . For these people it is important to every six months to control the state of the bone system.

When used as a doping Omnadren 250 there may be a manifestation of serious side effects.

On the ability to drive vehicles and operate machinery with serious drug treatment has no effect. Concentration may be reduced if a person develops heart failure.

Analogs Omnadren 250

Under current components counterparts Omnadren 250 - a medication Sustanon-250 . Tetrasteron . Testenat . If we evaluate the mechanism of action, the funds may be called analogues Nebido . TK Andriol . Testosterone propionate . Methyltestosterone . Androgel . All these drugs can be used to treat disease only after the approval of a physician.

Which is better: Omnadren or Sustanon?

Preparations Sustanon and Omnadren are similar both in composition and performance effects on the human body. Nevertheless, patients have noted that Sustanon has milder influence on the body. It is also noted that the treatment Sustanon less pronounced side effects.

Babies

Not applicable for the treatment of prepubertal boys.

During pregnancy and lactation

Contraindicated treatment Omnadrenom 250 during gestation and lactation. The period of lactation breastfeeding should be suspended.

Reviews Omnadrene 250

In a network there are different reviews Omnadrene 250. In particular, those patients who were treated with this drug, say the manifestation of certain side effects associated with the peculiarities of the drug.

It is noted that in long-term treatment were observed problems with the liver, water retention, appearance marked spots on the skin, and others. Also, due to the availability of this agent (it is offered not only to conventional pharmaceutical networks, but also realizes practically any Internet pharmacy ) Some users inject large doses, trying to achieve results in the active muscle mass. Because of the serious excess dosing and marked negative manifestations.

Price Omnadren 250, where to buy

Buy Omnadren 250 pharmacies in Moscow and to order the drug in other cities can be as low as 500 to 600 rubles per pack with 5 ampoules. If the vehicle in order for online pharmacies, the price omnadren delivery will be slightly higher. But this way is easiest to buy this drug in Perm, as well as in other cities in Russia (Ekaterinburg, Chelyabinsk, and others.). Where to buy Omnadren 250 in St. Petersburg, should recognize the specific sites of pharmaceutical networks, as well as at retail pharmacy trade.