Description overdue on 05/20/2013

Stimulator of regeneration. The active ingredient is isotretinoin . The active ingredient is a biologically active form of vitamin A, which may itself be synthesized in the human body. The basic substance does not enter into the relationship with subclasses (receptors alpha, beta, gamma) nuclear receptor retinoic acid . Isotretinoin in a short time becomes transretinoevuyu acid (tretionin) and other ligands of nuclear receptors, which ultimately interferes with the expression of the gene and protein synthesis (possibly as induction or inhibition). Under the influence of the drug reduced the number of products and sebaceous glands Reduced concentration   Propionibacterium acnes That eliminates using the drug Roaccutane acne. The drug does not possess antibacterial and antimicrobial activity. The drug stimulates the regeneration, slows down the terminal phase of keratinocyte differentiation, and has protivoseboreynoe keratolytic and anti-inflammatory effects. Roaccutane drug released in rectal suppositories, capsules. Analogs Roaccutane: Aknekutan, isotretinoin, erase, Retinoic ointment Retasol.

Indications:

Roaccutane indicated for the treatment of severe acne vulgaris genesis and course (with the formation of scars, age spots, abscesses, hemorrhages) are not treatable by other methods. The drug is indicated for violation of keratinization: Red hairy rosea , Hand-foot form keratoderma , Ichthyosis, keratosis pilaris . Tablets are effective in Roaccutane purulent hidradenitis Folliculitis (if the pathogen belongs to gram-negative flora), pink acne (the heavy version of the flow).

Contraindications:

The drug Roaccutane is not prescribed for A giperavitaminoze , Intolerance isotretinoin, during gestation or pregnancy in its planning. Rectal forms are not used for diseases of the rectum cancer. Instructions for use of the drug Roaccutane recommends prescribers with caution in the chronic course of pancreatitis, kidney disease and severe hepatic system in hypertriglyceridemia, diabetes, obesity, alcoholism.

Side effect:

Musculoskeletal system:   used in high doses leads to the development hyperostosis , Arthralgia. Side effects of the drug Roaccutane from senses : night blindness , A burning sensation in the eyes, xerophthalmia, optic neuritis , Discomfort when wearing the lenses of the visual perception, clarity, cataract. Skin: cheilitis , Skin rashes, infections of the skin, thinning hair, peeling of the skin   on the soles and palms, the development of photosensitivity, pruritus. Nervous system: pseudotumor of the brain (manifestations in the form of uncontrollable vomiting and nausea, headaches, disturbances of visual perception), suicidal thoughts, fatigue, psychosis Depression. The digestive tract:   dry mouth, dyspeptic symptoms, colitis hepatitis , Regional forms ileitis , Bleeding from the gums. Against the background of treatment with Roaccutane may change with the laboratory parameters: reduction of HDL cholesterol increase, triglycerides . When streaming suppository mass mestnorazdrazhayuschee possible effects, so it is recommended to keep the horizontal position after the administration of rectal suppositories for half an hour. The impact of medication on the fetus, and fetotoxic teratogenic influence : Causes malformations to the cardiovascular system, mikrooftalmiyu , Hydrocephalus or microcephaly, hypoplasia of the forearm, thigh, neck vertebrae, skull, finger phalanges, low position of the ears, cleft palate, or the complete lack of underdevelopment of the external auditory canal, premature closure of the epiphyseal growth zones developmental disorder thymus , Fusion of the fingers and toes, the various embodiments of bone adhesions, hernias and spinal cord, until the death of the fetus in the perinatal period. In experiments on animals medicine causes formation pheochromocytoma . The drug may also cause dryness and bleeding from the mucous membranes of the nose.

Mode of application:

Roaccutane acne:   therapy 2-4 weeks, daily intake - 0, 5 mg per 1 kg of body weight; second stage lasts 12-20 weeks of treatment, a daily 1 mg per kg body weight. The capsules are taken by mouth, while eating. Correction regimens carried out in view of the effectiveness of the medicament, the severity of side effects, tolerance of the active substance. Tangible therapeutic effect appears after 1-2 months of therapy, in some situations, to achieve remission require 4-5 months. If, within 15 weeks of a decline rashes on the skin by 70%, the drug overturned. In the case of confirmation of recurrent and persistent disease course requires mandatory break duration of 8 weeks before the start of the new course. If during treatment recorded new sharpening, it is recommended to decrease the dose of 0, 5 mg per 1 kg for 2 weeks. With purulent hidradenitis , Pink acne, folliculitis, caused by gram-negative flora Roaccutane tablets administered in a daily dose of 0, 5-1 mg per 1 kg of body weight, the course is designed for 4 months. Disorders of keratinization:   shows a medicament dose 4mg per 1 kg of body weight per day, the rate is 4 months. Upon reaching clinical remission goes to a low dosage. Rectal Suppositories   Roaccutane is administered before bedtime, therapy is designed for 8-12 weeks. The recommended length of time between treatment courses - 1-2 months.

Special instructions:

Responses to the drug Roaccutane indicate a good tolerability of the medicament under specified dosages, as well as high efficiency of the drug. In mild and moderate acne vulgaris during Roaccutane is not prescribed. Drug therapy requires a mandatory review of the state of the liver, lipid levels   (analysis is performed on an empty stomach). Patients suffering from diabetes requires constant monitoring of glucose levels. During treatment is recommended to abandon the use of contact lenses and glasses. Donors are prohibited from donating blood during the use of the drug, and within a month to complete the course of treatment (in contact with a blood recipient - a pregnant woman may be a manifestation embryotoxic or teratogenic effects of medication on the fetus). Women are strongly encouraged to use reliable contraception for 4 weeks before the course starts, during treatment and for one month after the completion of the drug Roaccutane. If pregnancy occurs in a specified time held its termination on medical grounds. During treatment is recommended to avoid UV   and increased insolation . When the colitis symptoms pseudotumor of the brain of the visual perception pills Roaccutane overturned. Be sure to conduct a neurological examination for registration of symptoms pseudotumor of the brain . The drug Roaccutane may have adverse effect on the ability to drive and perform all kinds of work requiring high concentration, especially in the early stages of treatment. Roaccutane can buy in a drugstore (presentation of the prescription form the doctor is not required). Specialized sites allow you to order Roaccutane Internet for home delivery. Produced dosage: 10 and 20 mg (capsule form). Roaccutane price ranges from 1,500 to 3,000 rubles. Recommended storage temperature isotretinoin - no more than 25 degrees Celsius.

Drug Interactions:

Minocycline and other tetracyclines   in combination with the level of Roaccutane increases intracranial pressure, reduce the effectiveness of isotretinoin. Thiazide diuretics Sulfonamides and other drugs that increase photosensitivity, increase the chance of sunburn. Simultaneous therapy retinoids   (adapalene, retinol, acitretin, tazarotene, tretinoin) leads to the development giperavitaminoza A.