Description overdue on 08/10/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Tablets Tenorik: indications for use
• Contraindications
• Side effects
• Tablets Tenorik: instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The composition of the drug Tenorik includes 2 active ingredients: atenolol   and chlorthalidone . To date, the drug is released in 2 dozirovkah.1 tablet can contain 50 mg atenolol   and 12 mg of 5 chlorthalidone and 100 mg atenolol   and 25 mg   chlorthalidone   respectively. As auxiliary substances in the preparation protrude corn starch, lactose, sodium lauryl sulfate, polyvinylpyrrolidone, talc, and isopropanol, silicon dioxide and magnesium stearate. A film coated tablet comprises isopropanol, methylene chloride, hypromellose, talc, titanium dioxide, and paraffin oil, and macrogol.

Product form

Tablets Tenorik film-coated and have a white or nearly white. In tablet form biconvex, round and have a break line on one side. Packaged pills may Tenorik in strips and blisters of 28 or 100 pieces. Strips and blisters in turn placed in a cardboard box with the instructions, which you can find a detailed description of the drug.

Pharmacological action

Tenorik is a combination antihypertensive drug, which has quite a long hypotensive effect.

Pharmacodynamics and pharmacokinetics

The combined use of   atenolol   and chlorthalidone but it has little effect on the pharmacokinetics and pharmacodynamics of the active ingredients of each formulation.

Atenolol

Absorption and distribution
When receiving the drug inside the active substance   atenolol   approximately 45-50% is absorbed from the gastrointestinal tract. Cmax of the active substance in blood plasma recorded 2-3 hours after administration. Relationship to plasma proteins is weak enough and is only 5-15%.

Metabolism and excretion
It is proved that atenolol at   not peculiar to severe liver   metabolism . More than 90% atenolol Which is absorbed into the systemic circulation excreted completely unchanged. A T1 / 2 of up to about 6-9 hours, but expressed   renal failure may cause the increase of this indicator, as the kidney is the main organ through which the removal of atenolol .

Chlorthalidone

Absorption and distribution
Before the drug into the active substance Tenorik chlorthalidone   60-65%. absorbed from the gastrointestinal tract. Cmax is fixed in plasma after about 10-12 hours. Chlorthalidone   It has a strong connection to plasma proteins, which is about 70-75%.

Withdrawal
Displayed chlorthalidone   kidney and T1 / 2 varies within 50 hours.

Tablets Tenorik: indications for use

In testimony to the use Tenorika indicated that this drug is recommended in the treatment regimen:

• at hypertension .

Contraindications

Not recommended for use in the treatment regimen pills Tenorik:

• with pronounced attacks bradycardia ;
• in the presence of   cardiogenic shock ;
• in severe and progressive   hypotension ;
• at metabolic acidosis ;
• with strong peripheral circulatory disorders;
• AV-blockade in the first and third degree;
• at SSS ;
• at   pheochromocytoma ;
• heart failure (acute and chronic);
• at   vasospastic angina   (the so-called Prinzmetal angina );
• in progressive asthma ;
• at obstructive bronchitis ;
• at diabetes ;
• at hypoglycemia ;
• at gout ;
• at myasthenia ;
• in acute hepatitis ;
• in acute   renal failure ;
• in children and adolescents up to 18 years;
• in case of hypersensitivity to the drug.

Side effects

When used in a regimen of pills Tenorik patients may experience discomfort from the following side effects:

Cardio-vascular system:
from bradycardia, enhance symptoms of heart failure, orthostatic hypotension, cold extremities, appearance of arrhythmias, AV-blockade, the symptoms of intermittent claudication, Raynaud's syndrome.

From the central and peripheral nervous system:
from confusion, dizziness, headaches, mood swings, acute psychosis, hallucinations, paresthesia, sleep disorders, fatigue, lethargy, disorientation, impaired vision.

From the digestive system:
from dry mouth, gastrointestinal disorders, increasing the degree of hepatic transaminases, hepatotoxicity with intrahepatic cholestasis, nausea (associated with the use of chlorthalidone), constipation, pancreatitis, anorexia.

From hemopoiesis system:
from leukopenia, purpura, thrombocytopenia, agranulocytosis, eosinophilia.

Dermatological reactions:
from alopecia, dry eyes, psoriasiform reactions, exacerbation of psoriasis, skin rashes, photosensitivity.

The respiratory system:
from bronchospasm .

From the laboratory parameters:
from hyperuricemia, hyponatremia, hypokalemia .

Other:
from increasing the number of anti-nuclear antibodies, reduced potency, impaired glucose tolerance .

Nevertheless, drug Tenorik usually well tolerated by patients. Side effects are rare, and so mild that are more transient.

Tablets Tenorik: instructions for use

Adults most commonly prescribed medications Tenorik average dose, which is 100 mg, and the recommended starting dose is 50 mg 1 time a day.
Elderly often Tenorik medication prescribed at lower doses.
Patients with impaired renal function is recommended when necessary to reduce the frequency of administration of the drug.
Please note that the instructions for use Tenorika contains information that, after a long course of treatment Tenorik cancellation should be carried out not abruptly but gradually.

Overdose

If overdose Tenorik patient may experience discomfort from bradycardia, hypotension, congestive heart failure, bronchospasm, seizures, excessive sleepiness.

To remove these symptoms in some cases may require hospitalization in the ICU, where doctors carried out under the supervision gastric lavage . In the case of strong hypotension and strong shock is recommended that a plasma or plasma substitute, and when bronchospasm   use bronchodilators. If necessary, also held hemodialysis   or hemoperfusion.

Cooperation

Simultaneous treatment with Tenorika dihydropyridine   ( nifedipine ) and its derivatives can cause increased risk of hypotension And patients who suffer from   latent cardiac insufficiency   this combination can be serious circulatory disorders .

It is also necessary to avoid simultaneous reception Cardiac glycosides   and   beta-blockers Because it can significantly increase the AV-conduction.

Beta-blockers   can also provoke an aggravation   rebound hypertension Which tend to occur after abrupt withdrawal of reception clonidine . If a treatment regimen indicated both drugs, the use of beta-blockers It must be stopped for several days until completion of reception clonidine . If it is necessary to replace the clonidine   on   Beta-blockers , The latter appointed a few days after completion of therapy with clonidine .

Please note that the use with extreme caution beta-blockers   simultaneously with the first class antiarrhythmics, since such a combination can occur summation cardiodepressive effect.

Cause neutralization effect beta-blockers   and a significant increase in blood pressure may be concomitant use of sympathomimetic agents such as epinephrine (adrenaline), norepinephrine (noradrenaline) .

Reduce the hypotensive effect beta-blockers and substances such as ibuprofen, indomethacin Which are salicylates and NSAIDs. Incidentally, the use of large doses of salicylates enhances the toxic effect of these substances on the CNS.

From receiving drugs which contain lithium, and should be abandoned, while the use of diuretics. This combination causes a reduction in renal clearance of lithium.

Increased risk and rapid development   hypotension   could provoke a combination of beta-blockers   and means for common anesthesia . The is also a risk of increased action curariform relaxants.

When you receive the drug Tenorik with MAO inhibitors, a class causes an increase in blood pressure.

In a joint reception and tablets Tenorik ACE inhibitors class ( captopril, enalapril ) At the initial stage of therapy may be a sharp increase of the antihypertensive effect.

When combined and Tenorika Corticosteroids, amphotericin B, furosemide   increases the excretion of potassium.

Action insulin   and the effectiveness of oral hypoglycemic agents may decrease while the use of Tenorikom. That is why patients who are taking these drugs need to regularly monitor blood glucose levels.

Antihypertensives such as tricyclic antidepressants, phenothiazines , and barbiturates, diuretics and vasodilators   may enhance the antihypertensive effect of tablets Tenorika.

Receiving   beta-blockers   together with the calcium channel blocker has a negative inotropic effect and leads to the potency of this effect. Especially careful in this case should be the patients who suffer from decreased myocardial contractility   and violations of the sinoatrial and AV-conduction, since this regimen can cause severe hypotension , Bradycardia and heart failure . Be careful! Do not use calcium channel blocker for 48 hours after the canceled appointment beta-blockers .

Severe bradycardia   It may also occur with a joint appointment and Tenorika reserpine, clonidine, guanfatsina.

Pay special attention to the fact that taking two or more drugs can either weaken or strengthen the effectiveness of each other.

Terms of sale

Tablets Tenorik released from pharmacies with a prescription physician.

Storage conditions

Tenorik Tablets should be stored in the most dry, cool and completely protected from sunlight. Care should be taken to ensure that the drug is out of the reach of children and teens site. The recommended storage temperature for this preparation varies between 20 and 25 ° C.

Shelf life

Use Tenorik pills on the pressure can be 3 years.

Analogs Tenorika

The main drug is analogue   Atenol But also enjoyed popularity Tenorika analogues such as Dinorik and Tenoret .

Reviews Tenorike

Average rating Tenorika forums is only 3, 3 to 5-point scale.

The main advantages of the drug Tenorik Visitors forums include:

• efficiency;
• low price.

The disadvantages of this drug panellists believe that these pills on the pressure:

• may become a cause long-term treatment hair loss   and Impotence ;
• cause convulsions .

After analyzing the responses of physicians Tenorike forums, we can conclude that before the start of its application must be sure to consult with your doctor. Also reviews of Tenorike often contain a recommendation to refuse acceptance of the drug for older people.

In the search engines one of the most common question is "Tablets Tenorik from what? "Specialists are responsible, that these pills are used exclusively in the treatment regimens in hypertension.

Information about the preparation Tenorik Wikipedia there.

Price Tenorika where to buy

Tenorika average price in Ukraine is UAH 35.

Buy medicine Tenorik in Moscow can be over 102 rubles.