Description overdue on 12/17/2014

• Composition
• Product form
• Pharmacological action
• Pharmacokinetics and pharmacodynamics
• Indications
• Contraindications
• Side effects
• Instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Rh immunoglobulin   It has the active ingredient in the composition of immunoglobulin the protein and glycine water for injection as an auxiliary substance.

Product form

It is produced in the form of a solution for intramuscular administration. The liquid is has a light yellow color or is a fully colorless, it is completely transparent or a little bit opalescent.

You may see a little sediment, which will disappear if the vial to shake. The package of cardboard can be 1 or 10 vials and ampoule opener.

Pharmacological action

Human immunoglobulin antirezus RhO (D)   - Protein fraction with immunological activity. It is isolated from the serum or plasma donors who initially tested for the absence of antibodies to HIV , Hepatitis C, and there was no blood surface antigen of hepatitis B. The active ingredient of the drug - immunoglobulin G, a part of which has a partial anti-Rho (D) antibodies. Under the influence of the drug in pregnant women with negative Rh, gave birth to children with a positive Rho (D), and underwent an abortion, provided Rho (D) positive blood men prevented Rh sensitization (ie, formation of Rho (D) antibodies).

Pharmacokinetics and pharmacodynamics

The highest antibody concentration in the blood of the patient is noted after 24 hours after the administration was conducted human immunoglobulin antirezus Rho (D) intramuscularly. Half-life of the body - four to five weeks.

Indications

This tool can be used for any other purpose specialist.   The drug is indicated for use in order to ensure the prevention of Rh-conflict, women with Rh-negative, in the following cases:

• at pregnancy   and the subsequent birth of a child with a positive Rh factor;
• during spontaneous or deliberate Termination of Pregnancy ;
• in case of interruption ectopic pregnancy ;
• when there is a threat of spontaneous abortion   in any trimester;
• after Amniocentesis And other procedures in which there is a risk that the fetal blood into the mother's blood was;
• in the case of abdominal injury.

Contraindications

Human immunoglobulin antirezus RhO (D) experts not appointed Rh-positive childbirth, and it can not receive Rh-negative puerperal sensitized to the antigen Rho (D) (provided that the detection in serum of Rh antibodies).

Side effects

Adverse reactions are rare. With the introduction of this drug, the following symptoms:

• hyperemia of of integuments in those places, where to is introduced solution of;
• in the first days after the injection - fever, dyspeptic symptoms;
• variety allergic reactions .

Very rarely can develop anaphylactic shock . Patients who entered the drug should remain under the supervision of a half-hour after the injection. An expert should be able to carry out, if necessary, antishock therapy.

Instructions for use (method and dosage)

Instructions on Rh immunoglobulin   It indicates that, before the introduction of the ampoule with solution necessary for two hours and kept at a temperature of from 18 to 22 ° C. Intravenous can not enter. To prevent the formation of foam in the syringe should dial needle solution with a wide clearance. Keep opening the bottle is impossible.

Intramuscularly is introduced one dose of the drug singly. Women after childbirth   Immunoglobulin is administered during the first three days.

When abortion   a nyxis is necessary to do immediately after surgery.

The need to introduce a specific dose means the full gestation pregnancy is determined depending on how much blood the fetus got into the mother's bloodstream.

To prevent birth is entered before a single dose (300 mg) means it is necessary to enter about 28 weeks of pregnancy. After 2-3 days after birth entered another dose of immunoglobulins, on condition that he was born Rh positive baby.

In the presence of threatened abortion in any of the periods of gestation have to enter a single dose of medication.

If it occurred spontaneous abortion   interrupt or   ectopic pregnancy   after 13 weeks gestation, it recommended the introduction of a dose of 1 means. When termination of pregnancy up to 13 weeks may be administered to a mini-dose (50 mg).

Indications and dosage of the drug in other cases, is determined solely by an expert. It also helps to determine which Rh immunoglobulin better.

Overdose

About overdose of the drug data are not available.

Cooperation

Administering drug therapy can be combined with other medicaments, including antibiotic.

Terms of sale

It can only be purchased with a prescription.

Storage conditions

It should be away from children, store in a dark, dry place with the temperature should be from 2 to 10 ° C. Do not use the ampoules, integrity or markings have been violated and, if changed physical properties of the solution in the vial. Transport the a medicine need to at a temperature from 2 to 10 ° C.

Shelf life

Shelf life of drugs - 3 years.

Cautions

Children of mothers who received injections before the birth of a human immunoglobulin antirezus Rh0 (D), may be at the birth of weak positive results of direct antiglobulin tests.

After administration of the drug a woman can receive any live vaccines not earlier than three months.

If you have accurate information that my father Rh0 (D) -negative, the drug can not be administered.

Rh-positive childbirth preparation is not administered.

Rh immunoglobulin during pregnancy and lactation

Where indicated, the drug is administered to women   during pregnancy , And also if necessary - after childbirth . This instruction must be strictly adhered to during pregnancy in which there is information about the dosage of the drug. Reviews women have demonstrated that the drug usually does not cause significant side effects. Is it possible to receive Rh immunoglobulin during pregnancy free, you need to learn in a particular medical institution.

Comments about Rh immunoglobulin

Reviews women with a negative Rh factor   indicate that the drug prevents complications associated with rhesus conflict. It is noted that rarely causes adverse drug reactions, but it should be taken strictly under medical supervision.

Price immunoglobulin antirezus where to buy

Price Rh Immunoglobulin GiperROU C / the D on the average makes 5000 rubles. Anti D immunoglobulin other manufacturers can be purchased at a lower price. Where to buy Rh immunoglobulin in Moscow, St. Petersburg, can be found in a medical facility where women have during pregnancy.