Description overdue on 08/22/2014

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Nicergoline
• Contraindications
• Side effects
• Instructions for use of nicergoline (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

As part of one ampoule Nicergoline ( lyophilisate Ie composition for the preparation of a solution intended for intramuscular injection) contains 4 mg. nicergoline   (active drug), as well as adjuvants such as a lactose (monohydrate laktolozy) and tartaric acid.

One tablet contains 10 mg. active substance, and potato starch, lactose, basic magnesium carbonate, stearic acid, povidone, and magnesium stearate.

The shell of the tablet form of the drug present compounds such as basic magnesium carbonate, colloidal silica (Aerosil), sucrose, povidone, beeswax, titanium dioxide, talc and medical gelatin.

Product form

Nicergoline is produced in the form   lyophilisate   (powder odorless white) in glass ampoules (4 mg.), which is filled into the cell outline from PVC and filled into cartons with a solvent for the preparation of injection (0, 9% solution   sodium chloride ) In ampoules of 5 ml., And with an abrasive or ceramic ampulnam lancet.

Biconvex tablets Nicergoline covered with a white envelope packaged in blisters. Typically, one carton drug is 30 tablets, each containing 10 mg. active drug.

Pharmacological action

This medicine has vasodilating   (i.e., influences cerebral artery ) Pharmacological intervention, and refers to the group alpha-adrenergic blocking agents .

Pharmacodynamics and pharmacokinetics

Inherently Nicergoline - it   a synthetic ergot alkaloid and a derivative of alpha-blocker In the chemical formula of which you can see remnants bromo nicotinic acid . The active substance, a part of the drug and ergoline derivative   It has a positive effect on the hemodynamic,   and metabolic processes occurring in   brain .

Thanks alpha1-adrenergic blocking effects of   the drug increases the rate of blood flow in the lung . limbs and the brain And reduced Platelet aggregation in blood and improves its rheological parameters . Besides the drug compound has antispasmodic   and at the same time myotropic effect on the muscle membrane of blood vessels, thereby increasing the permeability Glucose   and leveling effect ergolinovogo ring .

The preparation decreases vascular tone And saturates arterial flow glucose and oxygen. Nicergoline has a positive effect on arterial pressure Which while taking the drug in patients with hypertension   can gradually return to normal. The drug improves rheological parameters,   and also reduces the platelet aggregation and reinforces circulation at arteriopathy.

Bioavailability   the drug is approximately 60% of its maximum concentration nicergoline   in the blood reaches a half hours after the first dose. Excreted drug to be output by 80%   kidney Another 20% yield from faeces .

Indications Nicergoline

Indications for the use of nicergoline are:

• chronic or acute abnormalities in the cerebral metabolic vascular Which may be caused by hypertension, atherosclerosis, embolism, thrombosis, ischemic attack, vasospasms , and vascular dementia;
• Raynaud's disease ;
• violation peripheral circulation ;
• migraine ;
• limb arteriopathy ;
• vertigo ;
• endarteriit ;
• diabetic angiopathy ;
• disease cornea;
• Diabetic retinopathy ;
• neuropathy, optic nerve .

Contraindications

Do not use this medication:

• at hypersensitivity ;
• after suffering heart attack ;
• at hypotension ;
• at bradycardia ;
• at galactose intolerance ;
• during   beremennost and ;
• at the age of 18;
• during Breastfeeding I ;
• at galactose malabsorption glucose- ;
• at lactose deficiency s .

With extreme caution when taking the drug gout And when hyperuricemia   and in combination with drugs affecting excretion and uric acid metabolism .

Side effects

During treatment Nicergoline can appear side effects of the drug such as:

• reduction blood pressure;
• nausea ;
• abdominal pain ;
• dizziness ;
• diarrhea ;
• fever ;
• drowsiness ;
• allergic reaction ;
• insomnia ;
• increased levels uric acid.

Instructions for use of nicergoline (method and dosage)

The instructions for use tablets   Nicergoline said that the drug should be taken three times a day before meals equal dosage of 5-10 mg. The duration of treatment typically is 3 weeks, but at an acute medical need may be increased up to several months.

Lyophilizate   diluted before use with sodium chloride   (0, 9%) and injected intramuscularly twice a day at a dose of 2-4 mg. The dosage as a therapeutic treatment duration depend on the nature and severity of the disease, and the condition of the patient.

Patients with kidney disease   it is recommended to take the drug in minimal doses.

Overdose

Symptoms that signal the overdose are hypotension, orthostatic collapse,   and allergic reactions . In addition, in excess of recommended dosages Nicergoline enhanced severity of side effects.

Cooperation

Nicergoline enhances efficiency anxiolytic, antipsychotic and antihypertensive drugs . Kolestiramin , and   antacids   reduce the absorption of the drug stomach. Idiosyncrasy   may occur while using the drug with adrenostimulyatorov .

Terms of sale

Prescription.

Storage conditions

Nicergoline in tablet form is included in the list B, so the medicine to be stored at 25 ° C in the dark and children.

Lyophilizate   should be stored at a temperature not exceeding 10 ° C, out of reach of children.

Shelf life

2 years for the tablets and nicergoline for 3 years lyophilizate powder- Intended for intramuscular injection.

Cautions

Before the drug is prohibited to use narcotic drugs or alcohol. To avoid hypotension Especially at the beginning of use of the drug, after intramuscular   Nicergoline patients should stay for a while in a horizontal position.

When receiving the drug should refrain from driving and from school activities, paired with the need for instant psychomotor reactions and enhanced concentration. Elderly requires correction dose depending on the level   creatine in the blood .

Analogs Nicergoline

By analogues Nicergoline include drugs such as:

• Nilogrin;
• Nicergoline-Fereyg ;
• Sermion .

Babies

It contraindicated use of the drug during the therapeutic treatment of patients under 18 years of age.

With alcohol

Drinking alcohol during treatment Nicergoline prohibited.

During pregnancy (and lactation)

Period Pregnancy and lactation   are absolute contraindications of the drug.

Reviews Nicergoline

Many patients leave negative feedback on the nicergoline as facing its side effects, and for a long time do not feel the improvements and the medicinal effect of the drug.

Price Nicergoline where to buy

The average price of tablets Nicergoline (packaging, 30 pcs., 10 mg. Each) is 200 rubles.
The average price of injections for intramuscular injection (packaging with ampoules containing solvent nicergoline and 0, 9% sodium chloride ) Does not exceed 400 rubles.